Publications

P. de Zeeuw, L. Treps, M. García Caballero, U. Harjes, J. Kalucka, C. De Legher, K. Brepoels, S. Vinckier, J. Souffreau, A. Bouché, F. Taverna, J. Dehairs, A. Talebi, B. Ghesquière, J. Swinnen, L. Schoonjans, G. Eelen, M. Dewerchin & P. CARMELIET. Unexpected role of endothelial PCK2 beyond gluconeogenesis. Comm Biology (IF5.9) (accepted Mar 2024)

X. Yuan, W. Ruan, B. Bobrow, P. CARMELIET & H. K. Eltzschig. Targeting hypoxia-inducible factors: therapeutic opportunities and challenges. Nat Rev Drug Discov 23(3): 175-200 (2024) (IF = 120.1 ; C = 0) PubMed

X. Lu., F. le Noble, L. Yuan, Q. Jiang, B. de Lafarge, D. Sugiyama, C. Breant, F. Claes, F. De Smet, J. L. Thomas, M. Autiero, P. CARMELIET, M. Tessier-Lavigne & A. Eichmann. "Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system." Nature 625(7994): E12. (2024) (IF = 64.8 ; C = 0) PubMed

D. Jimenez-Blasco, J. Agulla, R. Lapresa, M. Garcia-Macia, V. Bobo-Jimenez, D. Garcia-Rodriguez, I. Manjarres-Raza, E. Fernandez, Y. Jeanson, S. Khoury, J.-C. Portais, D. Padro, P. Ramos-Cabrer, P. CARMELIET, A. Almeida & J. P. Bolaños. Weak neuronal glycolysis sustains cognition and organismal fitness. Nat Metab (IF 20.8) (accepted Mar 2024) Pre-print Bioarchives Sep 2023 Link

F. Bian, C. Goda, G. Wang, Y. W. Lan, Z. Deng, W. Gao, A. Acharya, A. A. Reza, J. Gomez-Arroyo, N. Merjaneh, X. Ren, J. Goveia, P. CARMELIET, V. V. Kalinichenko and T. V. Kalin (2024). FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4. EMBO Mol Med DOI: 10.1038/s44321-024-00064-8 (2024) (IF 11.1 ; C = 0) PubMed

S. Sheppard, K. Srpan, W. Lin, M. Lee, R. B. Delconte, M. Owyong, P. CARMELIET, D. M. Davis, J. B. Xavier, K. C. Hsu & J. C. Sun. Fatty acid oxidation fuels natural killer cell responses against infection and cancer. Proc Natl Acad Sci U S A 121(11): e2319254121 (2024) (IF = 10.700 ; C = 0) PubMed

M. Declercq, L. Treps, V. Geldhof, N. V. Conchinha, L. De Rooij, A. Subramanian, M.Feyeux, M. Cotinat, B. Boeckx, S. Vinckier, L. Dupont, F. Vermeulen, M. Boon, M. Proesmans, L. Libbrecht, J. Pirenne, D. Monbaliu, I. Jochmans, M. Dewerchin, G. Eelen, T. Roskams, S. Verleden, D. Lambrechts, P. CARMELIET & P. Witters. Single cell RNA sequencing of cystic fibrosis liver disease explants revealed alternative complement activation. Liver Int (IF = 6.7) (accepted Apr 2024)

Q. Zeng, M. Mousa, A. S. Nadukkandy, L. Franssens, H. Alnaqbi, F. Y. Alshamsi, H. A. Safar & P. CARMELIET. Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer 23(8): 544-564 (2023) (IF = 78.5 ; C = 4) PubMed

Lpmh de Rooij, L. M. Becker, L. A. Teuwen, B. Boeckx, S. Jansen, S. Feys, S. Verleden, L. Liesenborghs, A. K. Stalder, S. Libbrecht, T. Van Buyten, G. Philips, A. Subramanian, S. J. Dumas, E. Meta, M. Borri, L. Sokol, A. Dendooven, A. C. K. Truong, J. Gunst, P. Van Mol, J. D. Haslbauer, K. Rohlenova, T. Menter, R. Boudewijns, V. Geldhof, S. Vinckier, J. Amersfoort, W. Wuyts, D. Van Raemdonck, W. Jacobs, L. J. Ceulemans, B. Weynand, B. Thienpont, M. Lammens, M. Kuehnel, G. Eelen, M. Dewerchin, L. Schoonjans, D. Jonigk, J. van Dorpe, A. Tzankov, E. Wauters, M. Mazzone, J. Neyts, J. Wauters, D. Lambrechts, & P. CARMELIET. The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution. Cardiovasc Res 119(2): 520-535 (2023) (IF = 10.8 ; C 6) PubMed

L.M. Becker, S. H. Chen, J. Rodor, Lpmh de Rooij, A. H. Baker, & P. CARMELIET. 'Deciphering Endothelial Heterogeneity in Health and Disease at Single Cell Resolution: Progress and Perspectives', Cardiovasc Res 119(1):6-27(2023) (IF = 10.8 ; C = 11) PubMed

L. Sokol, A. Cuypers, A. K. Truong, A. Bouche, K. Brepoels, J. Souffreau, K. Rohlenova, S. Vinckier, L. Schoonjans, G. Eelen, M. Dewerchin, L. de Rooij & P. CARMELIET . Prioritization and functional validation of target genes from single-cell transcriptomics studies. Commun Biol 6(1): 648 (2023) (IF = 5.9 ; C = 0) PubMed

A.-C. Khanh Truong, N.  Dekoning, L. M. Becker, A. Bouché, K. Veys, B. Hosseinkhani, M. Dewerchin, G. Eelen & P. CARMELIET. Detailed protocol for a corneal thermal cauterization-based (lymph)angiogenesis assay in mice. MethodsX. 17:11:102446 (2023) (IF 1.9 ; C = 0) PubMed

X. Yuan , W. Ruan , B. Bobrow , P. CARMELIET & H. Eltzschig. Targeting hypoxia-inducible factors:Therapeutic opportunities and challenges. Nat. Rev. Drug Discov doi: 10.1038/s41573-023-00848-6 (2023) (IF = 120.1; C = 0) PubMed

X. Lu, F. le Noble, L. Yuan, Q. Jiang, B. de Lafarge, D. Sugiyama, C. Breant, F. Claes, F. De Smet, J. L. Thomas, M. Autiero, P. CARMELIET, M. Tessier-Lavigne and A. Eichmann. "Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system." Nature doi 10.1038/s41586-023-06944-2 (2023) (IF = 64.8) PubMed Editorial expression of concern Nat 2004

M. Ghobrial, M. Schwab,S. Takada, H. Zhong , S. Suntharalingham, S. Vetiska, D. Rodrigues Gonzalez ,R. Wu, H. Rehrauer, A.Dinesh, K. Yu , E. Che, J. Bisschop, F. Farnhammer, A. Mansur, L. Regli, K. Schaller, K. Frei, T. Ketela, M. Bernstein, P. Kongkham, P. CARMELIET, T. Valiante, P. Dirks, M. Suva, G. Zadeh, V. Tabar, R. Schlapbach, H. Jackson, K. De Bock, J. Fish, P. Monnier, G. Bader, I. Radovanovic & T. Wälchli. Molecular atlas of the human brain vasculature across development, adulthood and disease at the single-cell level. Nature (In Press 2023) (IF = 64.8)

C. Lee, R. Chen, G. Sun, X. Liu, X. Lin, C. He, L. Xing, L. Liu, L. D. Jensen, A. Kumar, H. F. Langer, X. Ren, J. Zhang, L. Huang, X. Yin, J. Kim, J. Zhu, G. Huang, J. Li, W. Lu, W. Chen, J. Liu, J. Hu, Q. Sun, W. Lu, L. Fang, S. Wang, H. Kuang, Y. Zhang, G. Tian, J. Mi, B. A. Kang, M. Narazaki, A. Prodeus, L. Schoonjans, D. M. Ornitz, J. Gariepy, G. Eelen, M. Dewerchin, Y. Yang, J. S. Ou, A. Mora, J. Yao, C. Zhao, Y. Liu, P. CARMELIET, Y. Cao & X. Li. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway. Signal Transduct Target Ther 8(1): 305 (2023) (IF39.3 ; C = 4) PubMed

T. Walchli, J. Bisschop, P. CARMELIET, G. Zadeh, P. P. Monnier, K. De Bock and I. Radovanovic Shaping the brain vasculature in development and disease in the single-cell era.  Nat Rev Neurosci: 1-28 (2023) (IF = 34.7 ; C = 14) PubMed

E.M. Ryan, P. Sadiku, P. Coelho, E. R. Watts, A. Zhang, A. J. M. Howden, M. A. Sanchez-Garcia, M. Bewley, J. Cole, B. J. McHugh, W. Vermaelen, B. Ghesquiere, P. CARMELIET, G. Rodriguez Blanco, A. Von Kriegsheim, Y. Sanchez, W. Rumsey, J. F. Callahan, G. Cooper, N. Parkinson, K. Baillie, D. A. Cantrell, J. McCafferty, G. Choudhury, D. Singh, D. H. Dockrell, M. K. B. Whyte & S. R. Walmsley. NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 207(8): 998-1011. (2023) (IF = 24.7 ; C = 4) PubMed

B. Morant-Ferrando, D. Jimenez-Blasco, P. Alonso-Batan, J. Agulla, R. Lapresa, D. Garcia-Rodriguez, S. Yunta-Sanchez, I. Lopez-Fabuel, E. Fernandez, P. CARMELIET, A. Almeida, M. Garcia-Macia & J. P. Bolanos. "Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition." Nat Metab 5(8): 1290-1302 (2023) (IF = 20.800 ; C = 4) PubMed

S. Crotta, M. Villa, J. Major, K. Finsterbusch, M. Llorian, P. CARMELIET, J. Buescher & A. Wack. Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation. Nat Commun, 14: 721 (2023) (IF = 16.6 ; C = 3) PubMed

J. Li, Y. Zhou, G. Eelen, Q. T. Zhou, W. B. Feng, V. Labroska, F. F. Ma, H. P. Lu, M. Dewerchin, P. CARMELIET, M. W. Wang & D. H. Yang. A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds. Acta Pharmacol Sin 44(3):680-692 (2023) (IF = 8.2 ; C = 1) PubMed

S.L. Armour, A. Frueh, M. V. Chibalina, H. Dou, L. Argemi-Muntadas, A. Hamiltion, G. Katzilieris-Petras, P. CARMELIET, B. Davies, T. Moritz, L. Eliasson, P. Rorsman & J. G. Knudsen. Glucose controls glucagon secretion by regulating fatty acid oxidation in pancreatic alpha cells. Diabetes  72(10): 1446-1459 (2023) (IF = 7.7 ; C = 1) PubMed

M. Fernandez-Cortes, D. Delgado-Bellido, E. Bermudez-Jimenez, J. M. Paramio, F. O'Valle, S. Vinckier, P. CARMELIET, A. Garcia-Diaz &  F. J. Oliver. PARP inhibition promotes endothelial-like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry. J Pathol 259, 3:318-330 (2023) (IF = 7.3 ; C = 2) PubMed

J. Amersfoort, G. Eelen & P. CARMELIET Immunomodulation by endothelial cells – partnering up with the immune system? Nat Rev Immunol 22(9): 576-588 (2022) Highly cited paper (IF = 100.3, C = 83) PubMed

Lpmh de Rooij, L. M. Becker & P. CARMELIET. 'A Role for the Vascular Endothelium in Post-Acute COVID-19?', Circulation 145: 1503-05 (2022) (IF = 37.8 ; C = 7) PubMed

V. Geldhof, L. PMH de Rooij, L. Sokol, J. Amersfoort, M. De Schepper, K. Rohlenova, G. Hoste, A. Vanderstichele, A.-M. Delsupehe, E. Isnaldi N. Dai, F. Taverna, S. Khan, A.-C. K. Truong, L.-A. Teuwen, F. Richard, L. Treps, A. Smeets, I. Nevelsteen, B. Weynand, S. Vinckier, L. Schoonjans, J. Kalucka, C. Desmedt, P. Neven, M. Mazzone, G. Floris, K. Punie, M. DEwerchin, G. Eelen, H. Wildiers, X. Li, Y. Luo & P. CARMELIET. Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast. Nat Commun 13(1): 5511 (2022) (IF = 16.6 ; C = 14) PubMed

A. Subramanian, P. Zakeri, M. Mousa, H. Alnaqbi, F. Y. Alshamsi, L. Bettoni, E. Damiani, H. Alsafar, Y. Saeys & P. CARMELIET. Angiogenesis goes computational - The future way forward to discover new angiogenic targets? Comput Struct Biotechnol J 20: 5235-55 (2022) (IF = 6.0 ; C = 2) PubMed

M. Garcia-Caballero, L. Sokol, A. Cuypers & P. CARMELIET.  Metabolic Reprogramming in Tumor Endothelial Cells', Int J Mol Sci, 21;23(19):11052. (2022) (IF = 5.6 ; C = 10) PubMed

A. Cuypers, A. K. Truong, L. M. Becker, P. Saavedra-Garcia, & P. CARMELIET.  Tumor vessel co-option: The past & the future. Front Oncol, 12: 965277 (2022) (IF = 4.7 ; C = 9) PubMed

A. Cuypers, L. A. Teuwen, V. L. Bridgeman, Lpmh de Rooij, G. Eelen, M. Dewerchin, A. R. Cantelmo, J. Kalucka, A. Bouche, S. Vinckier, A. Carton, A. Manderveld, P. B. Vermeulen, A. R. Reynolds & P. CARMELIET. Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells. STAR Protoc, 3: 101691 (2022) (IF = N/A ; C = 0) PubMed

Rossi, M., P. Altea-Manzano, M. Demicco, G. Doglioni, L. Bornes, M. Fukano, A. Vandekeere, A. M. Cuadros, J. Fernandez-Garcia, C. Riera-Domingo, C. Jauset, M. Planque, H. F. Alkan, D. Nittner, D. Zuo, L. A. Broadfield, S. Parik, A. A. Pane, F. Rizzollo, G. Rinaldi, T. Zhang, S. T. Teoh, A. B. Aurora, P. Karras, I. Vermeire, D. Broekaert, J. V. Elsen, M. M. L. Knott, M. F. Orth, S. Demeyer, G. Eelen, L. E. Dobrolecki, A. Bassez, T. V. Brussel, K. Sotlar, M. T. Lewis, H. Bartsch, M. Wuhrer, P. V. Veelen, P. CARMELIET, J. Cools, S. J. Morrison, J. C. Marine, D. Lambrechts, M. Mazzone, G. J. Hannon, S. Y. Lunt, T. G. P. Grunewald, M. Park, J. V. Rheenen & S. M. Fendt.  'PHGDH heterogeneity potentiates cancer cell dissemination and metastasis'. Nature 605(7911): 747-753 (2022) (IF = 64.8 ; C = 56) PubMed

Y.T. Ong, J. Andrade, M. Armbruster, C. Shi, M. Castro, A. S. H. Costa, T. Sugino, G. Eelen, B. Zimmermann, K. Wilhelm, J. Lim, S. Watanabe, S. Guenther, A. Schneider, F. Zanconato, M. Kaulich, D. Pan, T. Braun, H. Gerhardt, A. Efeyan, P. CARMELIET, S. Piccolo, A. R. Grosso & M. Potente. 'A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth'. Nat Metab 4: 672-82.(2022) (IF = 20.8 ; C = 12) PubMed

G. Wang, B. Heijs, S. Kostidis, A. Mahfouz, R. G. J. Rietjens, R. Bijkerk, A. Koudijs, L. A. K. van der Pluijm, C. W. van den Berg, S. J. Dumas, P. CARMELIET, M. Giera, B. M. van den Berg & T. J. Rabelink. Analyzing cell-type-specific dynamics of metabolism in kidney repair.  Nat Metab 4(9): 1109-1118 (2022) (IF = 20.8 ; C = 39) PubMed

O. Meçe, D. houbaert, M-L Sassano, T Durré, H Maes, M. Schaaf, S. More, M. Ganne, M. Garcia-Caballero, M. Borri, J. Verhoeven, M. Arawal, K. Jacobs, G. Bergers, S. Blacher, B. Ghesquière, M. Dewerchin, J. V Swinnen, S. Vinckier, M. Soengas, P. CARMELIET,  A. Noël & P. Agostinis. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis. Nat Commun 13(1): 2760 (2022) (IF = 16.6 ; C = 10) PubMed

F. Wang, P. Ding, X. Liang, X. Ding, C. B. Brandt, E. Sjostedt, J. Zhu, S. Bolund, L. Zhang, Lpmh de Rooij, L. Luo, Y. Wei, W. Zhao, Z. Lv, J. Hasko, R. Li, Q. Qin, Y. Jia, W. Wu, Y. Yuan, M. Pu, H. Wang, A. Wu, L. Xie, P. Liu, F. Chen, J. Herold, J. Kalucka, M. Karlsson, X. Zhang, R. B. Helmig, L. Fagerberg, C. Lindskog, F. Ponten, M. Uhlen, L. Bolund, N. Jessen, H. Jiang, X. Xu, H. Yang, P. CARMELIET, J. Mulder, D. Chen, L. Lin & Y. Luo. 'Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level'. Nat Commun, 13: 3620 (2022) (IF = 16.6 ; C  = 15) PubMed

Van Nyen, T., M. Planque, L. van Wagensveld, J. A. G. Duarte, E. A. Zaal, A. Talebi, M. Rossi, P. R. Korner, L. Rizzotto, S. Moens, W. De Wispelaere, R. E. M. Baiden-Amissah, G. S. Sonke, H. M. Horlings, G. Eelen, E. Berardi, J. V. Swinnen, C. R. Berkers, P. CARMELIET, D. Lambrechts, B. Davidson, R. Agami, S. M. Fendt, D. Annibali & F. Amant. Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers. Nat Commun, 13: 4578 (2022) (IF = 16.6 ; C  =13) PubMed

Magalhaes-Novais, S., J. Blecha, R. Naraine, J. Mikesova, P. Abaffy, A. Pecinova, M. Milosevic, R. Bohuslavova, J. Prochazka, S. Khan, E. Novotna, R. Sindelka, R. Machan, M. Dewerchin, E. Vlcak, J. Kalucka, S. Stemberkova Hubackova, A. Benda, J. Goveia, T. Mracek, C. Barinka, P. CARMELIET, J. Neuzil, K. Rohlenova & J. Rohlena. Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Autophagy 8;1-18 (2022) (IF = 13.3 ; C. = 9) PubMed

S. Stegen, S. Loopmans, I. Stockmans, K. Moermans, P. CARMELIET & G. Carmeliet.  De novo serine synthesis regulates chondrocyte proliferation during bone development and repair. Bone Res, 10: 14 (2022) (IF = 12.7 ; C = 6) PubMed

Saulnier-Sholler, G., D. G. Duda, G. Bergendahl, D. Ebb, M. Snuderl, T. W. Laetsch, J. Michlitsch, D. Hanson, M. S. Isakoff, K. Bielamowicz, J. M. Kraveka, W. Ferguson, P. Carmeliet, A. De Deene, L. Gijsen and R. K. Jain. A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma." Clin Cancer Res 28(18): 3950-3957 (2022) (IF = 11.5 ; C = 4) PubMed

K. van Kuijk, K., J. A. F. Demandt, J. Perales-Paton, T. L. Theelen, C. Kuppe, E. Marsch, J. de Bruijn, H. Jin, M. J. Gijbels, L. Matic, B. M. E. Mees, C. P. M. Reutelingsperger, U. Hedin, E. A. L. Biessen, P. CARMELIET, A. H. Baker, R. K. Kramann, L. J. Schurgers, J. Saez-Rodriguez & J. C. Sluimer. 'Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling', Cardiovasc Res 118: 1232-46 (2022) (IF = 10.8 ; C = 0) PubMed

J. Rodor, S. H. Chen, J. P. Scanlon, J. P. Monteiro, A. Caudrillier, S. Sweta, K. R. Stewart, A. Shmakova, R. Dobie, B. E. P. Henderson, K. Stewart, P. W. F. Hadoke, M. Southwood, S. D. Moore, P. D. Upton, N. W. Morrell, Z. Li, S. Y. Chan, A. Handen, R. Lafyatis, L. de Rooij, N. C. Henderson, P. CARMELIET, A. M. Spiroski, M. Brittan & A. H. Baker. Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension. Cardiovasc Res 118(11): 2519-2534 (2022) (IF = 10.8; C = 28) PubMed

Kumar, S., L. Bar-Lev, H. Sharife, M. Grunewald, M. Mogilevsky, T. Licht, J. Goveia, F. Taverna, I. Paldor, P. CARMELIET & E. Keshet. Identification of vascular cues contributing to cancer cell stemness and function. Angiogenesis 25(3): 355-371 (2022) (IF = 9.8 ; C = 7) PubMed

G. Tournaire, S. Loopmans, S. Stegen, G. Rinaldi, G. Eelen, S. Torrekens, K. Moermans, P. CARMELIET, B. Ghesquiere, B. Thienpont, S. M. Fendt, N. van Gastel & G. Carmeliet. 'Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle'. Cell Rep, 40: 111105 (2022) (IF = 8.8 ; C = 3) PubMed

Fernandez-Garcia, J., F. Franco, S. Parik, P. Altea-Manzano, A. A. Pane, D. Broekaert, J. van Elsen, I. Vermeire, T. Schalley, M. Planque, T. van Brussel, R. Schepers, E. Modave, T. K. Karakach, P. CARMELIET, D. Lambrechts, P. C. Ho, and S. M. Fendt. CD8(+) T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation', Cell Rep 41: 111639 (2022) (IF = 8.8 ; C = 5) PubMed

C. U. Vohwinkel, N. Burns, E. Coit, X. Yuan, E.  K. Vladar, C. Sul, E. P. Schmidt, P. CARMELIET, K. Stenmark,  E. S. Nozik, R. M. Tuder & H. K. Eltzschig. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight Vol724(2022) (IF = 8.0 ; C = 6) PubMed

X. Zheng, S. Narayanan, C. Xu, S. Eliasson Angelstig, J. Grunler, A. Zhao, A. Di Toro, L. Bernardi, M. Mazzone, P. CARMELIET, M. Del Sole, G. Solaini, E. A. Forsberg, A. Zhang, K. Brismar, T. A. Schiffer, N. Rajamand Ekberg, I. R. Botusan, F. Palm, and S. B. Catrina. Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes', Elife, 11 (2022) (IF = 7.7 ; C = 18) PubMed

M.S. Koning, S. J. Dumas, M. C. Avramut, R. I. Koning, E. Meta, E. Lievers, L. E. Wiersma, M. Borri, X. Liang, L. Xie, P. Liu, F. Chen, L. Lin, Y. Luo, J. Mulder, H. S. Spijker, T. Jaffredo, B. M. van den Berg, P.CARMELIET, C. W. van den Berg, and T. J. Rabelink. 'Vasculogenesis in kidney organoids upon transplantation', NPJ Regen Med  7: 40 (2022) (IF:7.2 ; C = 10) PubMed

S.J. Dumas, E. Meta, M. Borri, Y. Luo, X. Li, T.J. Rabelink & .P. CARMELIET. Phenotypic diversity and metabolic specialization of renal endothelial cells. Nat Rev Nephrol 25:1-24 (2021) (IF = 38.717 ; C = 40) PubMed

A. Subramanian, L. M. Becker & P. CARMELIET. Endothelial metabolism going single. Nat Metab 3: 593-594 (IF =  19.865 ; C = 2) PubMed

A. Pasut, Lisa M. Becker, A. Cuypers & P. CARMELIET. Endothelial cell plasticity at single-cell level. Angiogenesis 24(2): 311-326 (IF = 10.658 ; C = 37 )PubMed

L.A. Teuwen, L. De Rooij, A. Cuypers, K. Rohlenova, S.J. Dumas, M. Garcia-Caballero, E. Meta, J. Amersfoort, F. Taverna, L.M. Becker, N. Veiga, A.R. Cantelmo, V. Geldhof, N.V. Conchinha, J. Kalucka, L. Treps, L.C. Conradi, S. Khan, T.K. Karakach, S. Soenen, S. Vinckier, L. Schoonjans, G. Eelen, S. Van Laere, M. Dewerchin, L. Dirix, M. Mazzone, Y. Luo, P. Vermeulen & P. CARMELIET. Tumor vessel co-option probed by single-cell analysis. Cell Rep 35(11): 109253 (2021) (IF = 9.995 ; C = 38) PubMed

L. Sokol, V. Geldhof, M. Garcia-Caballero, N.V. Conchinha, S.J. Dumas, E. Meta, L.A. Teuwen, K. Veys, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, J. Goveia, K. Rohlenova, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka, & P. CARMELIET. Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver. STAR Protoc 2(2): 100489 (2021)(IF = N/A ; C = 0) PubMed

S.J. Dumas, E. Meta, N.V. Conchinha, L. Sokol, R. Chen, M. Borri, L.A. Teuwen, K. Veys, M. Garcia-Caballero, V. Geldhof, L. Treps, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET. Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis. STAR Protoc 2(3): 100523 (2021) (IF = N/A ; C = 40) PubMed

N.V. Conchinha, L. Sokol, L.A. Teuwen, K. Veys, S.J. Dumas, E. Meta, M. Garcia-Caballero, V. Geldhof, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET. Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle. STAR Protoc 2(3): 100508 (2021) (IF = N/A ; C = 9) PubMed

L.J. Ceulemans, M. Khan, S.J. Yoo, B. Zapiec, L. Van Gerven, J. Van Slambrouck, A. Vanstapel, D. Van Raemdonck, R. Vos, E. Wauters, J. Wauters, P. CARMELIET & P. Mombaerts. Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19. Lancet Respir Med (2021) (IF = 102.642 ; C = 19 ;  C = 19) PubMed

M. Declercq, P. de Zeeuw, N. Vasconcelos Conchinha, V. Geldhof, A. S. Ramalho, M. Garcia-Caballero, K. Brepoels, M. Ensinck, M. S. Carlon, M. J. Bird, S. Vinckier, M. Proesmans, F. Vermeulen, L. Dupont, B. Ghesquiere, M. Dewerchin, P. CARMELIET, D. Cassiman, L. Treps, G. Eelen & P. Witters. Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype. Eur Respir J 57: 200026 (2021) (IF = 33.795 ; C = 10) PubMed

M. Declercq, L. Treps, S. Bousfia, P. CARMELIET & P. Witters. Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension. Eur Respir J 58(2) (2021) (IF = 33.795 ; C = 0) PubMed

P. Sadiku, J.A. Willson, E.M. Ryan, D. Sammut, P. Coelho, E.R. Watts, R. Grecian, J.M. Young, M. Bewley, S. Arienti, A.S. Mirchandani, M.A. Sanchez Garcia, T. Morrison, A. Zhang, L. Reyes, T. Griessler, P. Jheeta, G.G. Paterson, C.J. Graham, J.P. Thomson, K. Baillie, A.A.R. Thompson, J.M. Morgan, A. Acosta-Sanchez, V.M. Darde, J. Duran, J.J. Guinovart, G. Rodriguez-Blanco, A. Von Kriegsheim, R.R. Meehan, M. Mazzone, D.H. Dockrell, B. Ghesquiere, P. CARMELIET, M.K.B. Whyte, & S.R. Walmsley. Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis. Cell Metab 33(2): 411-423 (2021) (IF = 31.373 ; C = 65) PubMed

J. Vandewalle, S. Timmermans, V. Paakinaho, L. Vancraeynest, L. Dewyse, T. Vanderhaeghen, C. Wallaeys, L. Van Wyngene, K. Van Looveren, L. Nuyttens, M. Eggermont, S. Dewaele, T.R. Velho, L.F. Moita, S. Weis, C. Sponholz, L.A. van Grunsven, M. Dewerchin, P. CARMELIET, K. De Bosscher, J. Van de Voorde, J.J. Palvimo & C. Libert. Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis. Cell Metab 33(9): 1763-1776 e1765 (2021) (IF = 31.373 ; C = 21) PubMed

L.J. Ceulemans, J. Van Slambrouck, P. De Leyn, H. Decaluwe, H. Van Veer, L. Depypere, V. Ceuterick, S.E. Verleden, A. Vanstapel, S. Desmet, P. Maes, M. Van Ranst, P. Lormans, G. Meyfroidt, A.P. Neyrinck, B.M. Vanaudenaerde, E. Van Wijngaerden, S. Bos, L. Godinas, P. CARMELIET, G.M. Verleden, D.E. Van Raemdonck & R. Vos. Successful double-lung transplantation from a donor previously infected with SARS-CoV-2. Lancet Respir Med 9(3): 315-318 (2021) (IF = 30.7 ; C = 31) PubMed

C. Ju, M. Wang, E. Tak, B. Kim, C. Emontzpohl, Y. Yang, X. Yuan, H. Kutay, Y. Liang, D.R. Hall, W.A. Dar, J.S. Bynon, P. CARMELIET, K. Ghoshal & H.K. Eltzschig. Hypoxia-inducible factor-1alpha-dependent induction of miR122 enhances hepatic ischemia tolerance. J Clin Invest 131(7): e140300 (2021) (IF = 19.456 ; C = 25) PubMed

T. Walchli, J. Bisschop, A. Miettinen, A. Ulmann-Schuler, C. Hintermuller, E.P. Meyer, T. Krucker, R. Walchli, P.P. Monnier, P. CARMELIET, J. Vogel & M. Stampanoni. Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain. Nat Protoc 16(10)4564-4610 (2021) (IF = 17.021 ; C = 14) PubMed

S.Y. Chong, O. Zharkova, S. Yatim, X. Wang, X.C. Lim, C. Huang, C.Y. Tan, J. Jiang, L. Ye, M.S. Tan, V. Angeli, H.H. Versteeg, M. Dewerchin, P. CARMELIET, C.S.P. Lam, M.Y. Chan, D.P.V. de Kleijn & J.W. Wang. Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis. Theranostics 11(19): 9243-9261 (2021) (IF = 11.6 ; C = 15) PubMed

S. Trenson, H. Hermans, S. Craps, P. Pokreisz, P. de Zeeuw, J. Van Wauwe, H. Gillijns, D. Veltman, F. Wei, E. Caluwe, R. Gijsbers, P. Baatsen, J.A. Staessen, B. Ghesquiere, P. CARMELIET, F. Rega, B. Meuris, B. Meyns, W. Oosterlinck, J. Duchenne, K. Goetschalckx, J.U. Voigt, M.C. Herregods, P. Herijgers, A. Luttun, and S. Janssens. Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease. Circ Heart Fail 14(1): e006979 (2021) (IF = 10.447 ; C = 13) PubMed

M.D. Mana, A.M. Hussey, C.N. Tzouanas, S. Imada, Y. Barrera Millan, D. Bahceci, D.R. Saiz, A.T. Webb, C.A. Lewis, P. CARMELIET, M.M. Mihaylova, A.K. Shalek & O.H. Yilmaz. High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity. Cell Rep 35(10): 109212 (2021) (IF = 9.995 ; C = 57) PubMed

A. De Zutter, H. Crijns, N. Berghmans, M. Garcia-Caballero, L. Vanbrabant, N. Portner, V. Vanheule, P. Verscheure, M.M. Siddiquei, A.M. Abu El-Asrar, P. CARMELIET, P. Van Wielendaele, I. De Meester, J. Van Damme, P. Proost & S. Struyf. The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors. Cancers (Basel) 13(20) (2021) (IF = 6.575 ; C = 9) PubMed

S. Stegen, C. S. Devignes, S. Torrekens, R. Van Looveren, P. CARMELIET & G. Carmeliet. Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice. J Bone Miner Res. 36(3): 604-616 (2021) (IF = 6.39 ; C = 27) PubMed

J.A.F. Demandt, K. van Kuijk, T.L. Theelen, E. Marsch, S.P. Heffron, E.A. Fisher, P. CARMELIET, E.A.L. Biessen & J.C. Sluimer. Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice. Front Cell Dev Biol 9: 664258 (2021) (IF = 6.081 ; C = 2) PubMed

R. Tillie, J. De Bruijn, J. Perales-Paton, L. Temmerman, Y. Ghosheh, K. Van Kuijk, M.J. Gijbels, P. CARMELIET, K. Ley, J. Saez-Rodriguez & J.C. Sluimer. Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis. Front Cell Dev Biol 9: 695684 (2021) (IF = 6.081 ; C = 0) PubMed

L. Treps, M. Declercq, S. Bousfia, P. CARMELIET & P. Witters. Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition. J. Cyst Fibros 13: S1569-1993 (2021) (IF = 5.527 ; C = 1) PubMed

A.M.N. Walker, N. Warmke, B. Mercer, N.T. Watt, R. Mughal, J. Smith, S. Galloway, N.J. Haywood, T. Soomro, K.J. Griffin, S.B. Wheatcroft, N.Y. Yuldasheva, D.J. Beech, P. CARMELIET. M.T. Kearney, and R.M. Cubbon. Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis. Endocrinology 162(8) (2021) (IF = 5.051 ; C = 12) PubMed

L. A. Teuwen, V. Geldhof, A. Pasut & P. CARMELIET. COVID-19: the vasculature unleashed. Nat Rev Immunol 20: 389-391 (2020) (IF = 53.1 ; C = 704) PubMed

J. Kalucka*, L.P.M.H de Rooij*, J. Goveia*, K. Rohlenova, S. Dumas, E. Meta, N.V. Conchinha, L.-A. Teuwen, K. Veys, M. Garcia-Caballero, S. Khan, V. Geldhof, L. Sokol, R. Chen, L. Treps, M. Borri, P. de Zeeuw, C. Dubois, T.K. Karakach, K. Falkenberg, M. Parys, X. Yin, S. Vinckier, Y. Du, R.A. Fenton, L. Schoonjans, M. Dewerchin, G. Eelen, B. Thienpont, L. Lin, L. Bolund, X. Li, Y. Luo & P. CARMELIET. A single cell transcriptome atlas of murine endothelial cells. Cell 180(4), 764-779 (2020) Highly Cited paper(IF = 41.5 ;  C = 544) PubMed

J. Goveia*, K. Rohlenova*, F. Taverna*, L.Treps*, L.-C. Conradi, A. Pircher, V Geldhof, L. de Rooij, J. Kalucka, L. Sokol, M. García-Caballero, J. Qian, L.-A. Teuwen, S. Khan, B. Boeckx, E. Wauters, H. Decaluwé, P. De Leyn, J. Vansteenkiste, B. Weynand, X. Sagaert, E. Verbeken, A. Wolthuis, B. Topal, W. Everaerts, H. Bohnenberger, A. Emmert, D. Panovska, F. De Smet, F. J.T. Staal, R. J. Mclaughlin, F. Impens, V. Lagani, S. Vinckier, M. Mazzone, L. Schoonjans, M. Dewerchin, G. Eelen, T. Karakach, H. Yang, J. Wang, L. Bolund,  L. Lin, B. Thienpont, X. Li, D. Lambrechts, Y. Luo & P. Carmeliet. An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates. Cancer Cell 37: 21-36 (2020) (IF31.7 ; C = 190) PubMed

K. Rohlenova, J. Goveia, M. Garcia-Caballero, A. Subramanian, J. Kalucka, L. Treps, K. D. Falkenberg, L. de Rooij, Y. Zheng, L. Lin, L. Sokol, L. A. Teuwen, V. Geldhof, F. Taverna, A. Pircher, L. C. Conradi, S. Khan, S. Stegen, D. Panovska, F. De Smet, F. J. T. Staal, R. J. McLaughlin, S. Vinckier, T. Van Bergen, N. Ectors, P. De Haes, J. Wang, L. Bolund, L. Schoonjans, T. K. Karakach, H. Yang, G. Carmeliet, Y. Liu, B. Thienpont, M. Dewerchin, G. Eelen, X. Li, Y. Luo & P. CARMELIET. Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. Cell Metab 31: 862-877 (2020) (IF = 27.2 ; C = 134) PubMed

G. Eelen, L. Treps, X. Li & P. CARMELIET. Basic and therapeutics aspects of angiogenesis updated. Circ Res 127:310–329 (invited review, highly cited) (2020) (IF = 17.3, C = 185) PubMed

S.J. Dumas, M. Garcia-Caballero & P. CARMELIET. Metabolic signatures of distinct endothelial phenotypes. Trends Endocrinol Metab 31: 580-595 (2020) (IF =  12.0 ; C = 34) PubMed

F. Taverna*, J. Goveia*, S. Khan, T. K. Karakach, K. Rohlenova, L. Treps, A. Subramanian, L. Schoonjans, M. Dewerchin, G. Eelen & P. CARMELIET. BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization. Nucleic Acids Res 48: W385-394 (2020) (IF = 16.9 ; C = 37) PubMed

S. J. Dumas, E. Meta, M. Borri, J. Goveia, K. Rohlenova, N. V. Conchinha, K. Falkenberg, L. A. Teuwen, L. de Rooij, J. Kalucka, R. Chen, S. Khan, F. Taverna, W. Lu, M. Parys, C. De Legher, S. Vinckier, T. K. Karakach, L. Schoonjans, L. Lin, L. Bolund, M. Dewerchin, G. Eelen, T. J. Rabelink, X. Li, Y. Luo & P. CARMELIET. Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation. J Am Soc Nephrol 31:118-138 (2020) (IF = 10.1 ; C = 86) PubMed

N. van Gastel, S. Stegen, G. Eelen, S. Schoors, A. Carlier, V. W. Daniëls, N. Baryawno, D. Przbylski, M. Depypere, P.-J. Stiers, D. Lambrechts, R. Van Looveren, S. Torrekens, A. Sharda, P. Agostinis, D. Lambrechts,F. Maes, J. V. Swinnen,L. Geris, H. Van Oosterwyck, B. Thienpont, P. CARMELIET, D. T. Scadden & G. Carmeliet. Lipid availability determines skeletal progenitor cell fate via SOX9. Nature 579: 111-117 (2020) (IF = 49.9 ; C = 114) PubMed

M. Shang, F. Cappellesso, R. Amorim, J. Serneels, F. Virga, G. Eelen, S. Carobbio, M. Y. Rincon, P. Maechler, K. De Bock, P. C. Ho, M. Sandri, B. Ghesquiere, P. CARMELIET, M. Di Matteo, E. Berardi & M. Mazzone. Macrophage-derived glutamine boosts satellite cells and muscle regeneration. Nature: 587: 626-631 (2020) (IF = 49.9 ; C =87) PubMed

T. Schmidt, B. Kharabi Masouleh, S. Loges, S. Cauwenberghs, P. Fraisl, C. Maes, B. Jonckx, K. De Keersmaecker, M. Kleppe, M. Tjwa, T. Schenk, S. Vinckier, R. Fragoso, M. De Mol, K. Beel, S. Dias, C. Verfaillie, R. E. Clark, T. H. Brummendorf, P. Vandenberghe, S. Rafii, T. Holyoake, A. Hochhaus, J. Cools, M. Karin, G. Carmeliet, M. Dewerchin & P. CARMELIET. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1(+) Leukemia.Cancer Cell 37: 135-136 (2020) (Erratum for Cancer Cell 2011) (IF = 31.7; C =0 ) PubMed

R. Kalluri, AJ Mead, MP di Magiano,M Filbin, P.CARMELIET & I. Amit. Single-Cell Analyses in the Multi-omics Era. Cancer Cell 38: 9-10 (2020) Editorial Material (IF = 31.7 ; C = 1) PubMed

J. Zhang, J. Muri, G. Fitzgerald, T. Gorski, R. Gianni-Barrera, E. Masschelein, G. D'Hulst, P. Gilardoni, G. Turiel, Z. Fan, T. Wang, M. Planque, P. CARMELIET, L. Pellerin, C. Wolfrum, S. M. Fendt, A. Banfi, C. Stockmann, I. Soro-Arnaiz, M. Kopf & K. De Bock. Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization. Cell Metab 31: 1136-1153 (2020) (IF = 27.2 ; C = 172) PubMed

J. Saravia, H. Zeng, Y. Dhungana, D. Bastardo Blanco, T. M. Nguyen, N. M. Chapman, Y. Wang, A. Kanneganti, S. Liu, J. L. Raynor, P. Vogel, G. Neale, P. CARMELIET & H. Chi. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv 6: eaaw6443 (2020) (IF = 14.1 ; C = 46) PubMed

K. Veys, Z. Fan, M. Ghobrial, A. Bouche, M. Garcia-Caballero, K. Vriens, N. V. Conchinha, A. Seuwen, F. Schlegel, T. Gorski, M. Crabbe, P. Gilardoni, R. Ardicoglu, J. Schaffenrath, C. Casteels, G. De Smet, I. Smolders, K. Van Laere, E. D. Abel, S. M. Fendt, A. Schroeter, J. Kalucka, A. R. Cantelmo, T. Walchli, A. Keller, P. CARMELIET & K. De Bock. Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity. Circ Res 31: 466-482 (2020) (IF = 17.3 ; C = 87) PubMed

G. D'Hulst, I. Soro-Arnaiz, E. Masschelein, K. Veys, G. Fitzgerald, B. Smeuninx, S. Kim, L. Deldicque, B. Blaauw, P. CARMELIET, L. Breen, P. Koivunen, S. M. Zhao & K. De Bock. PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase. Nat Commun 11: 174 (2020) (IF = 14.9 ; C = 21) PubMed

R. Boon, M. Kumar, T. Tricot, I. Elia, L. Ordovas, F. Jacobs, J. One, J. De Smedt, G. Eelen, M. Bird, P. Roelandt, G. Doglioni, K. Vriens, M. Rossi, M. A. Vazquez, T. Vanwelden, F. Chesnais, A. El Taghdouini, M. Najimi, E. Sokal, D. Cassiman, J. Snoeys, M. Monshouwer, W. S. Hu, C. Lange, P. CARMELIET, S. M. Fendt & C. M. Verfaillie. Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines. Nat Commun 11: 1393 (2020) (IF = 14.9 ; C = 60) PubMed

F. D'Anna, L. Van Dyck, J. Xiong, H. Zhao, R. V. Berrens, J. Qian, P. Bieniasz-Krzywiec, V. Chandra, L. Schoonjans, J. Matthews, J. De Smedt, L. Minnoye, R. Amorim, S. Khorasanizadeh, Q. Yu, L. Zhao, M. De Borre, S. N. Savvides, M. C. Simon, P. CARMELIET, W. Reik, F. Rastinejad, M. Mazzone, B. Thienpont & D. Lambrechts. DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance. Genome Biol 21: 182 (2020) (IF = 13.5 ; C = 30) PubMed

J. Leslie, M. G. Macia, S. Luli, J. C. Worrell, W. J. Reilly, H. L. Paish, A. Knox, B. S. Barksby, L. M. Gee, M. Y. W. Zaki, A. L. Collins, R. A. Burgoyne, R. Cameron, C. Bragg, X. Xu, G. W. Chung, C. D. A. Brown, A. D. Blanchard, C. B. Nanthakumar, M. Karsdal, S. M. Robinson, D. M. Manas, G. Sen, J. French, S. A. White, S. Murphy, M. Trost, J. L. Zakrzewski, U. Klein, R. F. Schwabe, I. Mederacke, C. Nixon, T. Bird, L. A. Teuwen, L. Schoonjans, P. CARMELIET, J. Mann, A. J. Fisher, N. S. Sheerin, L. A. Borthwick, D. A. Mann & F. Oakley. c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nat Metab: 2: 1350-1367 (IF = 13.5 ; C = 12) PubMed

S. Stegen, G. Rinaldi, S. Loopmans, I. Stockmans, K. Moermans, B. Thienpont, S. M. Fendt, P. CARMELIET & G. Carmeliet. Glutamine Metabolism Controls Chondrocyte Identity and Function. Dev Cell 53: 530-544 (2020) (IF = 12.2 ; C = 41) PubMed

L. Van Wyngene, T. Vanderhaeghen, S. Timmermans, J. Vandewalle, K. Van Looveren, J. Souffriau, C. Wallaeys, M. Eggermont, S. Ernst, E. Van Hamme, A. Goncalves, G. Eelen, A. Remmerie, C. L. Scott, C. Rombouts, L. Vanhaecke, L. De Bus, J. Decruyenaere, P. CARMELIET  & C. Libert. Hepatic PPARalpha function and lipid metabolic pathways are dysregulated in polymicrobial sepsis. EMBO Mol Med 12: e11319 (2020) (IF = 12.1 ; C = 27) PubMed

M. M. Vaeyens, A. Jorge-Penas, J. Barrasa-Fano, C. Steuwe, T. Heck, P. CARMELIET, M. Roeffaers & H. Van Oosterwyck. Matrix deformations around angiogenic sprouts correlate to sprout dynamics and suggest pulling activity. Angiogenesis 23: 315-324 (2020) (IF = 9.5 ; C = 36) PubMed

J. Dooley, V. Lagou, J. Goveia, A. Ulrich, K. Rohlenova, N. Heirman, T. Karakach, Y. Lampi, S. Khan, J. Wang, T. Dresselaers, U. Himmelreich, M. J. Gunter, I. Prokopenko, P. CARMELIET & A. Liston. Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility. Cell Rep 32: 107880 (2020) (IF = 9.4 ; C  = 5) PubMed

G. Wang, S. Kostidis, G. L. Tiemeier, W. Sol, M. R. de Vries, M. Giera, P. CARMELIET, B. M. van den Berg & T. J. Rabelink. Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis. Arterioscler Thromb Vasc Biol: 40: 350-364 (2020) (IF = 8.3 ; C = 59) PubMed

G. L. Tiemeier, R. de Koning, G. Wang, S. Kostidis, S. J. Dumas, M. Giera, C. W. van den Berg, J. C.J. Eikenboom, B. M. van den Berg, J.C.J. Eikenboom, B.M. van den Berg, P. CARMELIET & T. Rabelink. Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells indues formation of mature Weibel-Palade bodies. Stem Cell Transl Med 9(7): 758-772 (2020) (IF = 6.9 ; C = 7) PubMed)

X. Li, X. Sun & P. CARMELIET. Hallmarks of Endothelial Cell Metabolism in Health and Disease. Cell Metab 30: 414-433 (2019) (Review) (IF = 21.5 ; C = 218). PubMed

X. Li, A. Kumar & P. CARMELIET. Metabolic Pathways Fueling the Endothelial Cell Drive. Annu Rev Physiol 81: 483-503 (2019) (IF = 19.5 ; C = 76) PubMed

M. García-Caballero , A. Zecchin , J. Souffreau , A.-C. Khanh Truong , L.-A. Teuwen , W. Vermaelen , R. Martín-Pérez , P. de Zeeuw , A. Bouché , S. Vinckier , I. Cornelissen , G. Eelen , B. Ghesquière , M. Mazzone , M. Dewerchin & P. CARMELIET. Role and therapeutic potential of dietary ketone bodies for lymph vessel growth. Nat Metab 1, 666-75 (2019) (IF = N/A ; C = 36) PubMed

K.D. Falkenberg, K. Rohlenova, Y. Luo & P. CARMELIET. The metabolic engine of endothelial cells. Nat Metab 1,937-46 (2019) (IF =  N/A ; C =55) PubMed

S. Khan, F. Taverna, K. Rohlenova, L. Treps, V. Geldhof, L. de Rooij, L. Sokol, A. Pircher, L. C. Conradi, J. Kalucka, L. Schoonjans, G. Eelen, M. Dewerchin, T. Karakach, X. Li, J. Goveia & P. CARMELIET "EndoDB: a database of endothelial cell transcriptomics data." Nucleic Acids Res 47:D736-D744 (2019) (IF = 11.5 ; C = 60) PubMed

L. Teuwen, V. Geldhof & P. Carmeliet. How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development. Dev Biol 447:90-102 (2019) (Review) (IF = 2.8 ; C = 44) PubMed

C. Dubois, G. Eelen & P. CARMELIET. [New non-metabolic role for glutamine synthetase in angiogenesis]. Med Sci (Paris) 35: 407-409 (2019) (IF = 0.6 ; C = 10) PubMed

J. Kalucka, B. Ghesquiere, S. M. Fendt & P. CARMELIET. Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics. Methods Mol Biol 1978: 259-268 (2019) (IF = N/A ; C = 3) PubMed

B. M. van den Berg, G. Wang, M. G. S. Boels, M. C. Avramut, E. Jansen, W. Sol, F. Lebrin, A. Jan van Zonneveld, E. J. P. de Koning, H. Vink, H. J. Grone, P. CARMELIET, J. van der Vlag & T. J. Rabelink. Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium. J Am Soc Nephrol 31:118-138 (2019) (IF = 9.2 ; C = 50) PubMed

S. Stegen, K. Laperre, G. Eelen, G. Rinaldi, P. Fraisl, S. Torrekens, R. Van Looveren, S. Loopmans, G. Bultynck, S. Vinckier, F. Meersman, P. H. Maxwell, J. Rai, M. Weis, D. R. Eyre, B. Ghesquiere, S. M. Fendt, P. CARMELIET & G. Carmeliet. HIF-1alpha metabolically controls collagen synthesis and modification in chondrocytes. Nature 565:511-15 (2019) (IF = 42.7 ; C = 150) PubMed

D. A. Mogilenko, J. T. Haas, L. L'Homme, S. Fleury, S. Quemener, M. Levavasseur, C. Becquart, J. Wartelle, A. Bogomolova, L. Pineau, O. Molendi-Coste, S. Lancel, H. Dehondt, C. Gheeraert, A. Melchior, C. Dewas, A. Nikitin, S. Pic, N. Rabhi, J. S. Annicotte, S. Oyadomari, T. Velasco-Hernandez, J. Cammenga, M. Foretz, B. Viollet, M. Vukovic, A. Villacreces, K. Kranc, P. CARMELIET, G. Marot, A. Boulter, S. Tavernier, L. Berod, M. P. Longhi, C. Paget, S. Janssens, D. Staumont-Salle, E. Aksoy, B. Staels & D. Dombrowicz. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell 177: 1201-1216 e1219 (2019) (IF = 38.6 ; C = 86) PubMed

L. M. Charbonnier, Y. Cui, E. Stephen-Victor, H. Harb, D. Lopez, J. J. Bleesing, M. I. Garcia-Lloret, K. Chen, A. Ozen, P. CARMELIET, M. O. Li, M. Pellegrini & T. A. Chatila. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol20(9): 1208-1219 (2019 ; C =104) (IF = 20.4) PubMed

I. H. Jain, L. Zazzeron, O. Goldberger, E. Marutani, G. R. Wojtkiewicz, T. Ast, H. Wang, G. Schleifer, A. Stepanova, K. Brepoels, L. Schoonjans, P. CARMELIET, A. Galkin, F. Ichinose, W. M. Zapol & V. K. Mootha. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab: 30(4): 824-832 e3 (2019) (IF = 21.5 ; C = 61) PubMed

A. J. Harris, A. S. Mirchandani, R. W. Lynch, F. Murphy, L. Delaney, D. Small, P. Coelho, E. R. Watts, P. Sadiku, D. Griffith, R. S. Dickinson, E. Clark, J. A. Willson, T. Morrison, M. Mazzone, P. CARMELIET, B. Ghesquiere, C. O'Kane, D. McAuley, S. J. Jenkins, M. K. B. Whyte & S. R. Walmsley. IL4Ralpha Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo. Am J Respir Crit Care Med 200(2), 235-246 (2019) (IF = 17.4 ; C = 33)  PubMed

T. Vandoorne , K. Veys , W. Guo , A. Sicart , K. Vints , A. Swijsen , M. Moisse , G. Eelen , N. Gounko , L. Fumagalli , R. Fazal , C. Germeys , A. Quaegebeur , S.-M. Fendt , P. CARMELIET , C. Verfaillie , P. Van Damme , B. Ghesquière, K. De Bock & L. Van Den Bosch. Differentiation but not ALS mutations in FUS rewires motor neuron metabolism. Nat Commun 10(1): 4147 (2019) (IF = 12.1 ; C = 30) PubMed

D. Singer, K. Thamm, H. Zhuang, J. Karbanova, Y. Gao, J. V. Walker, H. Jin, X. Wu, C. R. Coveney, P. Marangoni, D. Lu, P. R. C. Grayson, T. Gulsen, K. J. Liu, S. Ardu, A. K. Wann, S. Luo, A. C. Zambon, A. M. Jetten, C. Tredwin, O. D. Klein, M. Attanasio, P. CARMELIET, W. B. Huttner, D. Corbeil & B. Hu. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J:38: (2019) (IF = 9.8 ; C = 39) PubMed

A. M. Gomes, E. C. Carron, K. L. Mills, A. M. Dow, Z. Gray, C. R. Fecca, M. A. Lakey, P. CARMELIET, F. Kittrell, D. Medina & H. L. Machado. Stromal Gas6 promotes the progression of premalignant mammary cells. Oncogene: 38:2437-50 (2019) (IF = 7.9 ; C =26) PubMed

G. L. Tiemeier, G. Wang, S. J. Dumas, W. Sol, M. C. Avramut, T. Karakach, V. V. Orlova, C. W. van den Berg, C. L. Mummery, P. CARMELIET, B. M. van den Berg & T. J. Rabelink. Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation. Stem Cell Rep.13: 803-816 (2019) (IF = 6 ; C = 13) PubMed

M. Declercq, L. Treps, P. CARMELIET & P. Witters. The role of endothelial cells in cystic fibrosis. J Cyst Fibros 18(6): 752-761 (2019) (IF = 4.7 ; C = 15) PubMed

V. R. Kay, L. S. Cahill, A. Hanif, J. G. Sled, P. CARMELIET, C. Tayade & B. A. Croy. Adult Pgf(-/-) mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor. Sci Rep 9: 9285 (2019) (IF = 3.9 ; C = 6) PubMed

J. Gomez-Escudero, C. Clemente, D. Garcia-Weber, R. Acin-Perez, J. Millan, J. A. Enriquez, K. Bentley, P. CARMELIET & A. G. Arroyo. PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production. Sci Rep 9: 15022 (2019) (IF = 3.9 ; C = 30) PubMed

A. S. Vanherwegen, G. Eelen, G. B. Ferreira, B. Ghesquiere, D. P. Cook, T. Nikolic, B. Roep, P. CARMELIET, S. Telang, C. Mathieu & C. Gysemans. Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism. J Steroid Biochem Mol Biol 187:134-45 (2019) (IF = 3.8 ; C = 65) PubMed

I. Geric, S. Schoors, C. Claes, P. Gressens, C. Verderio, C.M. Verfaillie, P.P. Van Veldhoven, P. CARMELIET & M. Baes. Metabolic Reprogramming during Microglia Activation. Immunometabolism 1e190002 (2019) (IF = N/A ; C = 0)

G. Eelen, C. Dubois, A.R. Cantelmo, J. Goveia, U. Bruning, M. DeRan, G. Jarugumilli, J. van Rijssel, G. Saladino, F. Comitani, A. Zecchin, S. Rocha, R. Chen, H. Huang, S. Vandekeere, J. Kalucka, C. Lange, F. Morales-Rodriguez, B. Cruys, L. Treps, L. Ramer, S. Vinckier, K. Brepoels, S. Wyns, J. Souffreau, L. Schoonjans, W.H. Lamers, Y. Wu, J. Haustraete, J. Hofkens, S. Liekens, R. Cubbon, B. Ghesquiere, M. Dewerchin, F.L. Gervasio, X. Li, J.D. van Buul, X. Wu & P. Carmeliet. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature 561(7721): 63 (2018) (IF = 43 ; C = 112) PubMed

X. Li & P. Carmeliet, Targeting angiogenic metabolism in disease. Science 359(6382): 1335-6 (2018) (IF = 41 ; C = 31) PubMed

D. Lambrechts, E. Wauters, B. Boeckx, S. Aibar, D. Nittner, O. Burton, A. Bassez, H. Decaluwe, A. Pircher, K. Van den Eynde, B. Weynand, E. Verbeken, P. De Leyn, A. Liston, J. Vansteenkiste, P. Carmeliet, S. Aerts & B.Thienpont. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med 24(8): 1277-89 (2018) Highly Cited (IF = 30.6 ; C = 925). PubMed

G. Eelen, P. de Zeeuw, L. Treps, U. Harjes, B.W. Wong & P. Carmeliet. Endothelial Cell Metabolism. Physiol Rev 98(1): 3-58 (2018) Highly Cited (IF = 24.2 ; C = 306) PubMed

S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Garcia-Caballero, J. Goveia, R. Chen, F. F. Diehl, L. Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S. Furuya, L. Schoonjans, G. Eelen, B. Ghesquiere, E. Keshet, X. Li, M. G. Vander Heiden, M. Dewerchin & P. CARMELIET. Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metab 28: 573-587 e513 (2018). (IF = 22.4 ; C = 106) PubMed

J. Kalucka, L. Bierhansl, N.V. Conchinha, R. Missiaen, I. Elia, U. Bruning, S. Scheinok, L. Treps, A.R. Cantelmo, C. Dubois, P. de Zeeuw, J. Goveia, A. Zecchin, F. Taverna, F. Morales-Rodriguez, A. Brajic, L.C. Conradi, S. Schoors, U. Harjes, K. Vriens, G.A. Pilz, R. Chen, R. Cubbon, B. Thienpont, B. Cruys, B.W. Wong, B. Ghesquiere, M. Dewerchin, K. De Bock, X. Sagaert, S. Jessberger, E.A.V. Jones, B. Gallez, D. Lambrechts, M. Mazzone, G. Eelen, X. Li, S.M. Fendt  & P. Carmeliet. Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis. Cell Metab 28:881-94 e813 (2018) (IF = 22.4 ; C = 140) PubMed

U. Bruning, F. Morales-Rodriguez, J. Kalucka, J. Goveia, F. Taverna, K.C.S. Queiroz, C. Dubois, A.R. Cantelmo, R. Chen, S. Loroch, E. Timmerman, V. Caixeta, K. Bloch, L.C. Conradi, L. Treps, A. Staes, K. Gevaert, A. Tee, M. Dewerchin, C.F. Semenkovich, F. Impens, B. Schilling, E. Verdin, J.V. Swinnen, J.L. Meier, R.A. Kulkarni, A. Sickmann, B. Ghesquiere, L. Schoonjans, X. Li, M. Mazzone & P. Carmeliet. Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Cell Metab 28:866-80 e815 (2018) (IF = 22.4 ; C = 128) PubMed

M.M. Mihaylova, C.W. Cheng, A.Q. Cao, S. Tripathi, M.D. Mana, K.E. Bauer-Rowe, M. Abu-Remaileh, L. Clavain, A. Erdemir, C.A. Lewis, E. Freinkman, A.S. Dickey, A.R. La Spada, Y. Huang, G.W. Bell, V. Deshpande, P. Carmeliet, P. Katajisto, D.M. Sabatini & O.H. Yilmaz. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell 22(5): 769-78 e4 (2018) (IF = 21.4 ; C = 228) PubMed

T.J. Rabelink & P. Carmeliet. Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease. Nat Rev Nephrol 14(2): 75-6 (2018) (IF = 19.6 ; C = 12) PubMed

K. Rohlenova, K. Veys, I. Miranda-Santos, K. De Bock & P. Carmeliet. Endothelial Cell Metabolism in Health and Disease. Trends Cell Biol 28(3): 224-36 (2018) (IF = 16.5 ; C = 175) PubMed

P. Carmeliet, X. Li, L. Treps, L.C. Conradi & S. Loges. RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients. Ann Oncol 29(3): 527-9 (2018) (IF = 14.1 ; C = 7) PubMed

J.G. Parchem, K. Kanasaki, M. Kanasaki, H. Sugimoto, L. Xie, Y. Hamano, S.B. Lee, V.H. Gattone, S. Parry, J.F. Strauss, V.D. Garovic, T.F. McElrath, K.H. Lu, B.M. Sibai, V.S. LeBleu, P. Carmeliet, & R. Kalluri. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. J Clin Invest 128:5008-17 (2018) (IF = 12.2 ; C =27) PubMed

J.A. Maybin, A.A. Murray, P.T.K. Saunders, N. Hirani, P. Carmeliet & H.O.D. Critchley. Hypoxia and hypoxia inducible factor-1alpha are required for normal endometrial repair during menstruation. Nat Commun 9(1): 295 (2018) (IF = 11.8 ; C = 91) PubMed

S. Stegen, I. Stockmans, K. Moermans, B. Thienpont, P.H. Maxwell, P. Carmeliet & G. Carmeliet, Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin. Nat Commun 9(1): 2557 (2018) (IF = 11.8 ; C = 91) PubMed

B.W. Wong, A. Zecchin, M. García-Caballero & P. Carmeliet. Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development. Dev Cell 45(3):289-301 (2018) (IF = 9.1 ; C = 46). PubMed

R. Bauer, F. Udonta, M. Wroblewski, I. Ben-Batalla, I.M. Santos, F. Taverna, M. Kuhlencord, V. Gensch, S. Pasler, S. Vinckier, J.M. Brandner, K. Pantel, C. Bokemeyer, T. Vogl, J. Roth, P. Carmeliet & S. Loges. Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of antiangiogenic therapy. Cancer Res 78:3220-32 (2018) (IF = 8.3 ; C = 77) PubMed

L.J.B. Briant, M.S. Dodd, M.V. Chibalina, N.J.G. Rorsman, P.R.V. Johnson, P. Carmeliet, P. Rorsman & J.G. Knudsen. CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets. Cell Rep 23(11): 3300-11 (2018) (IF = 7.8 ; C = 68) PubMed

M.A. Goyette, S. Duhamel, L. Aubert, A. Pelletier, P. Savage, M.P. Thibault, R.M. Johnson, P. Carmeliet, M. Basik, L. Gaboury, W.J. Muller, M. Park, P.P. Roux, J.P. Gratton & J.F. Cote. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. Cell Rep 23(5): 1476-90 (2018) (IF = 7.8 ; C = 103) PubMed

B. Lavina, M. Castro, C. Niaudet, B. Cruys, A. Alvarez-Aznar, P. Carmeliet, K. Bentley, C. Brakebusch, C. Betsholtz & K. Gaengel. Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations. Development 145(13) (2018) (IF = 5.7 ; C = 47) PubMed

P. Nowak-Sliwinska, K. Alitalo, E. Allen, A. Anisimov, A. C. Aplin, R. Auerbach, H. G. Augustin, D. O. Bates, J. R. van Beijnum, R. H. F. Bender, G. Bergers, A. Bikfalvi, J. Bischoff, B. C. Bock, P. C. Brooks, F. Bussolino, B. Cakir, P. CARMELIET, D. Castranova, A. M. Cimpean, O. Cleaver, G. Coukos, G. E. Davis, M. De Palma, A. Dimberg, R. P. M. Dings, V. Djonov, A. C. Dudley, N. P. Dufton, S. M. Fendt, N. Ferrara, M. Fruttiger, D. Fukumura, B. Ghesquiere, Y. Gong, R. J. Griffin, A. L. Harris, C. C. W. Hughes, N. W. Hultgren, M. L. Iruela-Arispe, M. Irving, R. K. Jain, R. Kalluri, J. Kalucka, R. S. Kerbel, J. Kitajewski, I. Klaassen, H. K. Kleinmann, P. Koolwijk, E. Kuczynski, B. R. Kwak, K. Marien, J. M. Melero-Martin, L. L. Munn, R. F. Nicosia, A. Noel, J. Nurro, A. K. Olsson, T. V. Petrova, K. Pietras, R. Pili, J. W. Pollard, M. J. Post, P. H. A. Quax, G. A. Rabinovich, M. Raica, A. M. Randi, D. Ribatti, C. Ruegg, R. O. Schlingemann, S. Schulte-Merker, L. E. H. Smith, J. W. Song, S. A. Stacker, J. Stalin, A. N. Stratman, M. Van de Velde, V. W. M. van Hinsbergh, P. B. Vermeulen, J. Waltenberger, B. M. Weinstein, H. Xin, B. Yetkin-Arik, S. Yla-Herttuala, M. C. Yoder & A. W. Griffioen. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis 21: 425-532 (2018) Review (IF = 5.7 ; C = 400) PubMed

K. L. Mills, A. M. Gomes, C. R. Standlee, M. D. Rojo, P. CARMELIET, Z. Lin & H. L. Machado. Gas6 is dispensable for pubertal mammary gland development. PLoS One 13: e0208550 (2018) (IF = 2.7 ; C = 8) PubMed

A. Zecchin, B.W. Wong, B. Tembuyser, J. Souffreau, A. Van Nuffelen, S. Wyns, S. Vinckier, P. Carmeliet & M. Dewerchin. Live imaging reveals a conserved role of fatty acid beta-oxidation in early lymphatic development in zebrafish. Biochem Biophys Res Commun 503(1): 26-31 (2018) (IF = 2.7 ; C = 3) PubMed

V.R. Kay, M.T. Ratsep, L.S. Cahill, A.F. Hickman, B. Zavan, M.E. Newport, J. Ellegood, C.L. Laliberte, J.N. Reynolds, P. Carmeliet, C. Tayade, J.G. Sled & B.A. Croy. Effects of placental growth factor deficiency on behavior, neuroanatomy and cerebrovasculature of mice. Physiol Genomics 50:862-75 (2018) (IF = 2.5 ; C = 14) PubMed

P. Yu, K. Wilhelm, A. Dubrac, J.K. Tung, T.C. Alves, J.S. Fang, Y. Xie, J. Zhu, Z. Chen, F. De Smet, J. Zhang, S.W. Jin, L. Sun, H. Sun, R.G. Kibbey, K.K. Hirschi, N. Hay, P. Carmeliet, T.W. Chittenden, A. Eichmann, M. Potente, & M. Simons. FGF-dependent metabolic control of vascular development. Nature 545(7653): 224-8 (2017) (IF = 41.5 ; C = 231) PubMed

B.W. Wong, X. Wang, A. Zecchin, B. Thienpont, I. Cornelissen, J. Kalucka, M. García-Caballero, R. Missiaen, H. Huang, U. Brüning, S. Blacher, S. Vinckier, J. Goveia, M. Knobloch, H. Zhao, C. Dierkes, C. Shi, R. Hägerling, V. Moral-Dardé, S. Wyns, M. Lippens, S. Jessberger, S.-M. Fendt, A. Luttun, A. Noel, F. Kiefer, B. Ghesquière, L. Moons, L. Schoonjans, M. Dewerchin, G. Eelen, D. Lambrechts & P. CARMELIET. The role of fatty acid beta-oxidation in lymphangiogenesis. Nature 542, 49-54 (2017) (IF = 41.5 ; C = 223) (Highlighted by national and international press). PubMed

F. Bifari, I. Decimo, A. Pino, E. Llorens-Bobadilla, S. Zhao, C. Lange, G. Panuccio, B. Boeckx, B. Thienpont, S. Vinckier, S. Wyns, A. Bouche, D. Lambrechts, M. Giugliano, M. Dewerchin, A. Martin-Villalba & P. Carmeliet. Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. Cell Stem Cell 20(3): 360-73 e67(2017) (IF = 23.2 ; C = 61) (Highlighted by national and international press) (featured cover article). Pubmed

W. A. Heggermont, A. P. Papageorgiou, A. Quaegebeur, S. Deckx, P. Carai, W. Verhesen, G. Eelen, S. Schoors, R. van Leeuwen, S. Alekseev, I. Elzenaar, S. Vinckier, P. Pokreisz, A. S. Walravens, R. Gijsbers, C. Van Den Haute, A. Nickel, B. Schroen, M. van Bilsen, S. Janssens, C. Maack, Y. Pinto, P. Carmeliet & S. Heymans. Inhibition of MicroRNA-146A and Overexpression of its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure-Overload Induced Cardiac Hypertrophy and Dysfunction. Circulation 136(8): 747-61 (2017) (IF = 18.8 ; C = 48) PubMed

P. Caruso, B. Dunmore, K. Schlosser, S. Schoors, C. Dos Santos, C. Perez-Iratxeta, J. Lavoie, H. Zhang, L. Long, A. Flockton, M. Frid, P. Upton, A. D'Alessandro, C. Hadinnapola, F. Kiskin, M. Taha, L. Hurst, M. Ormiston, A. Hata, K. Stenmark, P. Carmeliet, D. Stewart & N. Morrell. Identification of microRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation 136(25): 2451-67 (2017) (IF = 18.8 ; C = 162) PubMed

J. Kalucka, L.A. Teuwen, V. Geldhof & P. Carmeliet. How to Cross the Lymphatic Fence: Lessons from Solute Transport. Circ Res 120(9): 1376-8 (2017) (Editorial) (IF = 15.2 ; C = 1) PubMed

M. Potente & P. Carmeliet. The link between angiogenesis and endothelial metabolism. Annu  Rev Physiol 79: 43-66 (2017) (Review) (IF = 14.3 ; C = 227) PubMed

A.R. van Vliet, F. Giordano, S. Gerlo, I. Segura, S. Van Eygen, G. Molenberghs, S. Rocha, A. Houcine, R. Derua, T. Verfaillie, J. Vangindertael, H. De Keersmaecker, E. Waelkens, J. Tavernier, J. Hofkens, W. Annaert, P. Carmeliet, A. Samali, H. Mizuno & P. Agostinis. The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling. Mol Cell 65(5): 885-99 e86 (2017) (IF = 14.2 ; C = 134) PubMed

P. Sadiku, J.A. Willson, R.S. Dickinson, F. Murphy, A.J. Harris, A. Lewis, D. Sammut, A.S. Mirchandani, E. Ryan, E.R. Watts, A.A.R. Thompson, H.M. Marriott, D.H. Dockrell, C.T. Taylor, M. Schneider, P.H. Maxwell, E.R. Chilvers, M. Mazzone, V. Moral, C.W. Pugh, P.J. Ratcliffe, C.J. Schofield, B. Ghesquiere, P. Carmeliet, M.K.B. Whyte & S.R. Walmsley. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest 127(9): 3407-20 (2017) (IF = 13.2 ; C = 63) PubMed

S. Monteagudo, F.M.F. Cornelis, C. Aznar-Lopez, P. Yibmantasiri, L.A. Guns, P. Carmeliet, F. Cailotto & R.J. Lories. DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun 8: 15889 (2017) (IF = 12.3 ; C = 100) PubMed

J.R. Hernandez-Fernaud, E. Ruengeler, A. Casazza, L.J. Neilson, E. Pulleine, A. Santi, S. Ismail, S. Lilla, S. Dhayade, I.R. MacPherson, I. McNeish, D. Ennis, H. Ali, F.G. Kugeratski, H. Al Khamici, M. van den Biggelaar, P.V. van den Berghe, C. Cloix, L. McDonald, D. Millan, A. Hoyle, A. Kuchnio, P. Carmeliet, S.M. Valenzuela, K. Blyth, H. Yin, M. Mazzone, J.C. Norman, and S. Zanivan. Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nat Commun 8: 14206 (2017) (IF = 12.3 ; C = 66) PubMed

J. Schweisgut, C. Schutt, S. Wust, A. Wietelmann, B. Ghesquiere, P. Carmeliet, S. Drose, K.S. Korach, T. Braun & T. Boettger. Sex-specific, reciprocal regulation of ERalpha and miR-22 controls muscle lipid metabolism in male mice. EMBO J 36(9): 1199-214 (2017) (IF = 10.5 ; C = 24) PubMed

H. Huang, S. Vandekeere, J. Kalucka, L. Bierhansl, A. Zecchin, U. Bruning, A. Visnagri, N. Yuldasheva, J. Goveia, B. Cruys, K. Brepoels, S. Wyns, S. Rayport, B. Ghesquiere, S. Vinckier, L. Schoonjans, R. Cubbon, M. Dewerchin, G. Eelen & P. Carmeliet. Role of glutamine and interlinked asparagine metabolism in vessel formation. EMBO J 36(16): 2334-52 (2017) (IF = 10.5 ; C = 186) (featured cover article) PubMed

B.W. Wong, E. Marsch, L. Treps, M. Baes & P. Carmeliet. Endothelial cell metabolism in health and disease: impact of hypoxia. EMBO J 36:2187-2203 (2017) (Review) (IF = 10.5 ; C = 173) PubMed

W. Sents, B. Meeusen, P. Kalev, E. Radaelli, X. Sagaert, E. Miermans, D. Haesen, C. Lambrecht, M. Dewerchin, P. Carmeliet, J. Westermarck, A. Sablina & V. Janssens. PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. Cancer Res 77(24): 6825-37 (2017) (IF = 9.1 ; C = 29) PubMed

I. Ben-Batalla, R. Erdmann, H. Jorgensen, R. Mitchell, T. Ernst, G. von Amsberg, P. Schafhausen, J.L. Velthaus, S. Rankin, R.E. Clark, S. Koschmieder, A. Schultze, S. Mitra, P. Vandenberghe, T.H. Brummendorf, P. Carmeliet, A. Hochhaus, K. Pantel, C. Bokemeyer, G.V. Helgason, T.L. Holyoake & S. Loges. Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia. Clin Cancer Res 23(9): 2289-300 (2017) (IF = 10.1 ; C = 35) PubMed

M. Knobloch, G.A. Pilz, B. Ghesquiere, W.J. Kovacs, T. Wegleiter, D.L. Moore, M. Hruzova, N. Zamboni, P. Carmeliet & S. Jessberger. A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity. Cell Rep 20(9): 2144-2155 (2017) (IF = 8 ; C = 192) PubMed

K. Van der Borght, C.L. Scott, V. Nindl, A. Bouche, L. Martens, D. Sichien, J. Van Moorleghem, M. Vanheerswynghels, S. De Prijck, Y. Saeys, B. Ludewig, T. Gillebert, M. Guilliams, P. Carmeliet & B.N. Lambrecht. Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells. Cell Rep 18(12): 3005-17 (2017) (IF = 8 ; C = 77) PubMed

M.G. Mori da Cunha, S. Zia, D.V. Beckmann, M.S. Carlon, F.O. Arcolino, M. Albersen, N.L. Pippi, D.L. Graca, C. Gysemans, P. Carmeliet, E. Levtchenko, J. Deprest & J. Toelen. Vascular Endothelial Growth Factor Up-regulation in Human Amniotic Fluid Stem Cell Enhances Nephroprotection After Ischemia-Reperfusion Injury in the Rat. Crit Care Med 45(1): e86-e96 (2017) (IF = 6.6 ; C = 22) PubMed

S. Van Welden, M. De Vos, B. Wielockx, S.J. Tavernier, M. Dullaers, S. Neyt, B. Descamps, L. Devisscher, S. Devriese, L. Van den Bossche, T. Holvoet, A. Baeyens, C. Correale, S. D'Alessio, C. Vanhove, F. De Vos, B. Verhasselt, G. Breier, B.N. Lambrecht, S. Janssens, P. Carmeliet, S. Danese, D. Elewaut, D. Laukens & P. Hindryckx. Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis. J Pathol 241(4): 547-58 (2017) (IF = 6.2 ; C 27) PubMed

T. Walchli, A. Ulmann-Schuler, C. Hintermuller, E. Meyer, M. Stampanoni, P. Carmeliet, M.Y. Emmert, O. Bozinov, L. Regli, M.E. Schwab, J. Vogel & S.P. Hoerstrup. Nogo-A regulates vascular network architecture in the postnatal brain. J Cereb Blood Flow Metab 37(2): 614-31 (2017) (IF = 6 ; C = 18) PubMed

L. Bierhansl, L.C. Conradi, L. Treps, M. Dewerchin & P. Carmeliet. Central Role of Metabolism in Endothelial Cell Function and Vascular Disease. Physiology 32(2): 126-40 (2017) (Review) (IF = 5.9 ; C = 68) PubMed

A. Zecchin, J. Kalucka, C. Dubois & P. Carmeliet How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors. Front Immunol 8: 1750 (2017) (Review) (IF = 5.5 ; C = 78) PubMed

T. P. Bachor, J. Karbanová, E. Büttner, V. Bermúdez, M.M. Ramella, P. Carmeliet, D. Corbeil & A. M. Suburo. Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes. Neurobiol Dis 108: 13-28 (2017) (IF = 5.2 ; C = 9) PubMed

A.R. Cantelmo, A. Pircher, J. Kalucka & P. Carmeliet. Vessel pruning or healing: endothelial metabolism as a novel target? Expert Opin Ther Targets 21(3): 239-47 (2017) (Review) (IF = 4.5 ; C = 38) PubMed

L.C. Conradi, A. Brajic, A.R. Cantelmo, A. Bouche, J. Kalucka, A. Pircher, U. Bruning, L.A. Teuwen, S. Vinckier, B. Ghesquiere, M. Dewerchin & P. Carmeliet. Tumor vessel disintegration by maximum tolerable PFKFB3 blockade. Angiogenesis 20(4): 599-613 (2017) (IF = 4.3 ; C = 68) PubMed

S.J. Tavernier, N. Vanlangenakker, J. Vetters, P. Carmeliet, S. Janssens & B.N. Lambrecht. Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages. J Leukocyte Biol 102(4): 1115-26 (2017) (IF = 4.2 ; C = 5) PubMed

Y. Feng, P. Cui, X. Lu, B. Hsueh, F. Moller Billig, L. Zarnescu Yanez, R. Tomer, D. Boerboom, P. Carmeliet, K. Deisseroth & A.J. Hsueh. CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions. Sci Rep 7: 44810 (2017) (IF = 4.1 ; C = 77) PubMed

R. Missiaen, F. Morales-Rodriguez, G. Eelen & P. Carmeliet. Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective. Vascul Pharmacol 90: 8-18 (2017)  (Review) (IF = 3.6 ; C = 36) PubMed

N. Draoui, P. de Zeeuw & P. Carmeliet. Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism. Open Biol 7(12) pii: 170219 (2017) (Review) (IF = 3.2 ; C = 85) PubMed

L.A. Teuwen, N. Draoui, C. Dubois & P. Carmeliet. Endothelial cell metabolism: an update anno 2017. Cur Opin Hematol 24(3): 240-7 (2017) (Review) (IF = 2.8 ; C = 24) PubMed

J. Kalucka, L. Bierhansl, B. Wielockx, P. Carmeliet & G. Eelen. Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling. Pflugers Archiv 469(3-4): 473-83 (2017) (Review) (IF = 2.7 ; C = 38) PubMed

D. Ciarlillo, C. Celeste, P. Carmeliet, D. Boerboom & C. Theoret. A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice. Plos One 12(7): e0180586 (2017) (IF = 2.7 ; C = 20) PubMed

V.R. Kay, C. Tayade, P. Carmeliet & B.A. Croy. Influences of Placental Growth Factor on Mouse Retinal Vascular Development. Dev Dynam 246(9): 700-12 (2017) (IF = 2.5 ; C = 9) PubMed

A.A. Thompson, R.S. Dickinson, F. Murphy, J.P. Thomson, H.M. Marriott, A. Tavares, J. Willson, L. Williams, A. Lewis, A. Mirchandani, P. Dos Santos Coelho, C. Doherty, E. Ryan, E. Watts, N.M. Morton, S. Forbes, R.H. Stimson, A.G. Hameed, N. Arnold, J.A. Preston, A. Lawrie, V. Finisguerra, M. Mazzone, P. Sadiku, J. Goveia, F. Taverna, P. Carmeliet, S.J. Foster, E.R. Chilvers, A.S. Cowburn, D.H. Dockrell, R.S. Johnson, R.R. Meehan, M.K. Whyte & S.R. Walmsley. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism. Sci Immunol 2(8) pii: eaal2861 (2017) (IF = N/A ; C = 51) PubMed

K. Wilhelm, K. Happel, G. Eelen, S. Schoors, M.F. Oellerich, R. Lim, B. Zimmermann, I.M. Aspalter, C.A. Franco, T. Boettger, T. Braun, M. Fruttiger, K. Rajewsky, C. Keller, J.C. Bruning, H. Gerhardt, P. Carmeliet & M. Potente. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature 529: 216-20 (2016) (IF = 42.3, C = 389) (Listed as “highly cited paper” on Web of Science) (Highlighted by national and international press). PubMed

B. Thienpont, J. Steinbacher, H. Zhao, F. D’Anna, A. Kuchnio, A. Ploumakis, B. Ghesquière, L. Van Dyck, B. Boeckx, L. Schoonjans, E. Hermans, F. Amant, V. N. Kristensen, K.P. Koh, M. Mazzone, M. Coleman, T. Carell, P. Carmeliet & D. Lambrechts. Tumor hypoxia causes DNA hyper-methylation by reducing TET activity. Nature 537: 63-8 (2016) (IF = 42.3, C = 457) (Highlighted by national and international press) PubMed

R. Gallardo, M. Ramakers, F. De Smet, F. Claes, L. Khodaparast, J.R. Couceiro, T. Langenberg, M. Siemons, S. Nyström, LJ. Young, RF. Laine, L. Young, E. Radaelli, I. Benilova, M. Kumar, A. Staes, M. Desager, M. Beerens, P. Vandervoort, A. Luttun, K. Gevaert, G. Bormans, M. Dewerchin,  J. Van Eldere, P. Carmeliet, G. Vande Velde, C. Verfaillie, CF. Kaminski, B. De Strooper, P. Hammarström, KP. Nilsson, L. Serpell, J. Schymkowitz & F. Rousseau. De novo design of a biologically active amyloid. Science 354: 6313 (2016) (IF = 34.6 ; C = 56) PubMed

AR. Cantelmo, LC. Conradi, A. Brajic, J. Goveia, J. Kalucka, A. Pircher, P. Chaturvedi, J. Hol, B. Thienpont, LA. Teuwen, S. Schoors, B. Boeckx, J. Vriens, A. Kuchnio, K. Veys, B. Cruys, L. Finotto, L. Treps, TE. Stav-Noraas, F. Bifari, P. Stapor, I. Decimo, K. Kampen, K. De Bock, G. Haraldsen, L. Schoonjans, T. Rabelink, G. Eelen, B. Ghesquière, J. Rehman, D. Lambrechts, AB. Malik, M. Dewerchin & P. Carmeliet. Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy. Cancer Cell 30: 968-85 (2016) (IF = 27.4 ; C = 417) (Highlighted by Preview in Cancer Cell and by national and international press) PubMed

C. Herbert, U. Schieborr, K. Saxena, J. Juraszek, F. De Smet, C. Alcouffe, M. Bianciotto, G. Saladino, D. Sibrac, D. Kudlinzki, S. Sreeramulu, A. Brown, P. Rigon, JP. Herault, G. Lassalle, TL. Blundell, F. Rousseau, A. Gils, J. Schymkowitz, P. Tompa, JM. Herbert, P. Carmeliet, FL. Gervasio, H. Schwalbe & F. Bono. Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling. Cancer Cell 30: 176-78 (2016) (corrigendum) (IF = 27.4).

L. Treps, L.C. Conradi, U. Harjes & P. Carmeliet. Manipulating Angiogenesis by targeting endothelial metabolism: hitting the engine rather than the drivers - a new perspective? Pharmacol Rev 68: 872-87 (2016) (Review) (IF = 18.4 ; C = 42) PubMed

C. Lange, E. Storkebaum, C.R. de Almodovar, M. Dewerchin & P. Carmeliet. Vascular endothelial growth factor: a neurovascular target in neurological diseases. Nat Rev Neurol 12: 439-54 (Review) (2016) (IF = 18.4 ; C = 226) PubMed

S. Rafii & P. Carmeliet. VEGF-B Improves Metabolic Health through Vascular Pruning of Fat. Cell Metab 23(4): 571-3 (2016) (Review) (IF = 16.7 ; C = 10) PubMed

M.M. Wouters, D. Balemans, S. Van Wanrooy, J. Dooley, V. Cibert-Goton, Y.A. Alpizar, E.E. Valdez-Morales, Y. Nasser, P.P. Van Veldhoven, W. Vanbrabant, S. Van der Merwe, R. Mols, B. Ghesquiere, C. Cirillo, I. Kortekaas, P. Carmeliet, W.E. Peetermans, S. Vermeire, P. Rutgeerts, P. Augustijns, P.W. Hellings, A. Belmans, S. Vanner, D.C. Bulmer, K. Talavera, P. Vanden Berghe, A. Liston & G.E. Boeckxstaens. Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome. Gastroenterology  150: 875-87 e79 (2016) (IF = 16.7 ; C = 249) PubMed

S. Stegen, N. van Gastel, G. Eelen, B. Ghesquiere, F. D'Anna, B. Thienpont, J. Goveia, S. Torrekens, R. Van Looveren, F.P. Luyten, P.H. Maxwell, B. Wielockx, D. Lambrechts, S.M. Fendt, P. Carmeliet & G. Carmeliet. HIF-1alpha promotes glutamine-mediated redox homeostasis and glycogen-dependent bioenergetics to support postimplantation bone cell survival. Cell Metab 23: 265-79 (2016) (IF = 16.7 ; C = 131) PubMed

A. Quaegebeur, I. Segura, R. Schmieder, D. Verdegem, I. Decimo, F. Bifari, T. Dresselaers, G. Eelen, D. Ghosh, S.M. Davidson, S. Schoors, D. Broekaert, B. Cruys, K. Govaerts, C. De Legher, A. Bouche, L. Schoonjans, M.S. Ramer, G. Hung, G. Bossaert, D.W. Cleveland, U. Himmelreich, T. Voets, R. Lemmens, C.F. Bennett, W. Robberecht, K. De Bock, M. Dewerchin, B. Ghesquiere, S.M. Fendt & P. Carmeliet. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metab 23: 280-91 (2016) (IF = 16.7 ; C = 65) (Highlighted by national and international press). PubMed

M. Wenes, M. Shang, M. Di Matteo, J. Goveia, R. Martin-Perez, J. Serneels, H. Prenen, B. Ghesquière, P. Carmeliet & M. Mazzone. Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis. Cell Metab 24: 701-15 (2016) (IF = 16.7 ; C = 316) (Highlighted by Preview in Cell Metab and by national and international press) PubMed

E. Marsch, J.A. Demandt, T.L. Theelen, B.M. Tullemans, K. Wouters, M.R. Boon, T.H. van Dijk, M.J. Gijbels, L.J. Dubois, S.J. Meex, M. Mazzone, G. Hung, E.A. Fisher, E.A. Biessen, M.J. Daemen, P.C. Rensen, P. Carmeliet, A.K. Groen & J.C. Sluimer. Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. Eur Heart J 37(39): 2993-97 (2016) (IF = 15.2 ; C = 34) PubMed

M.S. Eiymo Mwa Mpollo, E.B. Brandt, S.K. Shanmukhappa, P.I. Arumugam, S. Tiwari, A. Loberg, D. Pillis, T. Rizvi, M. Lindsey, B. Jonck, P. Carmeliet, V.K. Kalra, T.D. Le Cras, N. Ratner, M. Wills-Karp, G.K. Hershey & P. Malik. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. J Clin Invest 126: 571-84 (2016) (IF = 13.3 ; C = 33) PubMed

B. Cruys, B.W. Wong, A. Kuchnio, D. Verdegem, AR. Cantelmo, LC Conradi, S Vandekeere, A. Bouché, I Cornelissen, S. Vinckier, R.M. Merks, E Dejana, H. Gerhardt, M. Dewerchin, K. Bentley & P. Carmeliet. Glycolytic regulation of cell rearrangement in angiogenesis. Nat Commun 7: 12240 (2016) (IF = 11.4 ; C = 121) PubMed

C. Lange, M. Turrero Garcia, I. Decimo, F. Bifari, G. Eelen, A. Quaegebeur, R. Boon, H. Zhao, B. Boeckx, J. Chang, C. Wu, F. Le Noble, D. Lambrechts, M. Dewerchin, C.J. Kuo, W.B. Huttner & P. Carmeliet. Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J 35: 924-41 (2016) (IF = 10.4 ; C = 131) (highlighted by (inter)-national press) PubMed

R. Jones, K. McDonald, J. A. Willson, B. Ghesquière, D. Sammut, E. Daniel, A. J. Harris, A. Lewis,R. Thompson, R. S. Dickinson, T. Plant, F. Murphy, P. Sadiku, B. G. Keevil, P. Carmeliet, M. K. Whyte, J. Newell-Price & S. R. Walmsley. Mutations in Succinate Dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1alpha expression. Blood 127: 2641-4 (2016) (IF = 10.4) PubMed

M. Manetti, I. Rosa, M. Fazi, S. Guiducci, P. Carmeliet, L. Ibba-Manneschi & M. Matucci-Cerinic. Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice. Ann Rheum Dis 75: 474-8 (2016) (IF = 10.3 ; C = 16) PubMed

U. Harjes, C. Verfaillie & P. Carmeliet. Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches. Dev Cell 37: 210-12 (2016) (Preview) (IF = 9.7 ; C = 5) PubMed

J. Incio, J. Tam, N.N. Rahbari, P. Suboj, D.T. McManus, S.M. Chin, T.D. Vardam, A. Batista, S. Babykutty, K. Jung, A. Khachatryan, T. Hato, J.A. Ligibel, I.E. Krop, S.B. Puchner, C.L. Schlett, U. Hoffmman, M. Ancukiewicz, M. Shibuya, P. Carmeliet, R. Soares, D.G. Duda, R.K. Jain & D. Fukumura. PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity. Clin Cancer Res 22(12): 2993-3004 (2016) (IF = 8.7 ; C = 101) PubMed

J. Goveia, A. Pircher, L.C. Conradi, J. Kalucka, V. Lagani, M. Dewerchin, G. Eelen, R. J. DeBerardinis, I. Wilson & P. Carmeliet. Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities. EMBO Mol Med 8: 1134-42 (2016) (IF = 8.5 ; C = 69) PubMed

I. Segura, C. Lange, E. Knevels, A. Moskalyuk, R. Pulizzi, G. Eelen, T. Chaze, C. Tudor, C. Boulegue, M. Holt, D. Daelemans, M. Matondo, B. Ghesquiere, M. Giugliano, C. Ruiz de Almodovar, M. Dewerchin & P. CARMELIET. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep 14: 2653-67 (2016) (IF = 8.3 ; C = 46) PubMed

S. Diaz-Moralli, E. Aguilar, S. Marin, J.F. Coy, M. Dewerchin, M.R. Antoniewicz, O Meca-Cortès, L. Notebaert, B. Ghesquière, G. Eelen, T.M. Thomson, P. Carmeliet & M. Cascante. A key role for  transketolase-like 1 in tumor metabolic reprogramming. Oncotarget 7(32): 51875-97 (2016) (IF = 6.3 ; C = 36) PubMed

Y. Jung, A.M. Decker, J. Wang, E. Lee, L.A. Kana, K. Yumoto, F.C. Cackowski, J. Rhee, P. Carmeliet, L. Buttitta, T.M. Morgan & R.S. Taichman. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget 7(18): 25698-711 (2016) (IF = 6.3 ; C = 33) PubMed

U. Harjes, J. Kalucka & P. Carmeliet. Targeting fatty acid metabolism in cancer and endothelial cells. Crit Rev Oncol Hematol 97: 15-21 (2016) (Review)  (IF = 5.0 ; C = 64) PubMed

S. Stegen, S. Deprez, G. Eelen, S. Torrekens, R. Van Looveren, J. Goveia, B. Ghesquiere, P. Carmeliet & G. Carmeliet. Adequate hypoxia inducible factor 1alpha signaling is indispensable for bone regeneration. Bone 87: 176-86 (2016) (IF = 3.9 ; C = 39) PubMed

A. Pircher, L. Treps, N. Bodrug & P. Carmeliet. Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities. Atherosclerosis 253: 247-57 (2016) (Review) (IF = 3.9 ; C = 67) PubMed

D. Verdegem, D. Lambrechts, P. Carmeliet & B. Ghesquière. Improved metabolite identification with MIDAS and MAGMa through MS/MS spectral dataset-driven parameter optimization. Metabolomics 12: 98 (2016) (IF = 3.7 ; C = 31) Metabolomics

R.L. Luna, V.R. Kay, M.T. Ratsep, K. Khalaj, M. Bidarimath, N. Peterson, P. Carmeliet, A. Jin & B.A. Croy. Placental growth factor deficiency is associated with impaired cerebral vascular development in mice. Mol Hum Reprod 22(2): 130-42 (2016) (IF = 3.7 ; C = 47) PubMed

Y.P. Vandewynckel, D. Laukens, L. Devisscher, E. Bogaerts, A. Paridaens, A. Van den Bussche, S. Raevens, X. Verhelst, C. Van Steenkiste, B. Jonckx, L. Libbrecht, A. Geerts, P. Carmeliet & H. Van Vlierberghe. Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma. BMC Cancer 16(1): 9 (2016) (IF = 3.4 ; C = 24) PubMed

T. Santos-Ferreira, M. Volkner, O. Borsch, J. Haas, P. Cimalla, P. Vasudevan, P. Carmeliet, D. Corbeil, S. Michalakis, E. Koch, M.O. Karl & M. Ader. Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy. Invest Ophthalmol Vis Sci 57(7): 3509-20 (2016) (IF = 3.4 ; C = 63) PubMed

T. Santos-Ferreira, M. Volkner, O. Borsch, J. Haas, P. Cimalla, P. Vasudevan, P. Carmeliet, D. Corbeil, S. Michalakis, E. Koch, M.O. Karl & M. Ader. Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation. Invest Ophthalmol Vis Sci 57(13): 5336-7 (2016) (IF = 3.4 ; C = 0) PubMed

S.F. Fitzpatrick, Z. Fabian, B. Schaible, C.R. Lenihan, T. Schwarzl, J. Rodriguez, X. Zheng, Z. Li, M.M. Tambuwala, D.G. Higgins, Y. O'Meara, C. Slattery, M.C. Manresa, P. Fraisl, U. Bruning, M. Baes, P. Carmeliet, G. Doherty, A. von Kriegsheim, E.P. Cummins & C.T. Taylor. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kappaB-dependent manner. Biochem Biophys Res Commun 474(3): 579-86 (2016) (IF = 2.9 ; C = 25) PubMed

N. Kaesler, S. Immendorf, C. Ouyang, M. Herfs, N. Drummen, P. Carmeliet, C. Vermeer, J. Floege, T. Kruger & G. Schlieper. Gas6 protein: its role in cardiovascular calcification. BMC Nephrol 17(1): 52 (2016) (IF = 1.69 ; C = 19) PubMed

E. Bogaerts, A. Paridaens, X. Verhelst, P. Carmeliet, A. Geerts, H. Van Vlierberghe & L. Devisscher. Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis. EXCLI J 15: 687-98 (2016) (IF = 1.2 ; C = 5) PubMed

R. Missiaen, S. Schoors, M. Dewerchin & P. Carmeliet. Het endotheelcel metabolisme: een nieuw aangrijpingspunt voor de onderdrukking van pathologische bloedvatvorming. Oncohematology 9: 8-12 (2016) (Review) (IF = N/A ; C = 0).

H. Maes, A. Kuchnio, P. Carmeliet & P. Agostinis. Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature. Mol Cell Oncol 3(1): e970097 (2016) (Review) (IF = N/A ; C = 0) PubMed

S. Schoors, U. Bruning, R. Missiaen, K.C. Queiroz, G. Borgers, I. Elia, A. Zecchin, A.R. Cantelmo, S. Christen, J. Goveia, W. Heggermont, L. Godde, S. Vinckier, P.P. Van Veldhoven, G. Eelen, L. Schoonjans, H. Gerhardt, M. Dewerchin, M. Baes, K. De Bock, B. Ghesquiere, S.Y. Lunt, S.M. Fendt & P. Carmeliet. Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature 520: 192-197 (2015) (IF = 42.3, C = 426) (Full Article, with News & Views in Nature, listed as a “highly cited” publication by Web of Science) (highlighted by (inter)-national press).  PubMed

G. Coppiello, M. Collantes, M.S. Sirerol-Piquer, S. Vandenwijngaert, S. Schoors, M. Swinnen, I. Vandersmissen, P. Herijgers, B. Topal, J. van Loon, J. Goffin, F. Prosper, P. Carmeliet, J.M. Garcia-Verdugo, S. Janssens, I. Penuelas, X.L. Aranguren & A. Luttun.  Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake. Circulation 131: 815-26 (2015) (IF = 14.9 ; C = 79) PubMed

G. Eelen, P. de Zeeuw, M. Simons  & P. Carmeliet. Endothelial cell metabolism in normal and diseased vasculature. Circ Res 116: 1231-44 (2015) (Review) (IF = 11.1, C = 432) PubMed

M. Simons, K. Alitalo, B. Annex, H.G. Augustin, C. Beam, B.C. Berk, T. Byzova, P. Carmeliet, W. Chilian, J.P. Cooke, G. E. Davis, A. Eichmann, M.L. Iruela-Arispe, E. Keshet, A.J. Sinusas, C. Ruhrberg, Y.J. Woo, S. Dimmeler & American Heart Association Council on Basic Cardiovascular, S. Council on Cardiovascular & Anesthesia. State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement from the American Heart Association. Circ Res 116: e99-132 (2015) (Review) (IF = 11.1 ; C = 110) PubMed

H. Huang, J. He, D. Johnson, Y. Wei, Y. Liu, S. Wang, G. A. Lutty, E. J. Duh, P. CARMELIET & R. D. Semba. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1alpha-VEGF pathway inhibition. Diabetes 64: 200-12 (2015) (IF = 8.7 ; C = 5) PubMed

A. Kuchnio, S. Moens, U. Bruning, K. Kuchnio, B. Cruys, B. Thienpont, M. Broux, A. A. Ungureanu, R. Leite de Oliveira, F. Bruyere, H. Cuervo, A. Manderveld, A. Carton, J. R. Hernandez-Fernaud, S. Zanivan, C. Bartic, J. M. Foidart, A. Noel, S. Vinckier, D. Lambrechts, M. Dewerchin, M. MazzoneA. & P. Carmeliet. The cancer cell oxygen sensor PHD2 promotes metastasis via activation of cancer-associated fibroblasts. Cell Rep 12: 992-1005 (2015) (IF = 8.3 ; C 69) (highlighted by (inter)-national press). PubMed

G.B. Ferreira, A.S. Vanherwegen, G. Eelen, A.C. Gutierrez, L. Van Lommel, K. Marchal, L. Verlinden, A. Verstuyf, T. Nogueira, M. Georgiadou, F. Schuit, D.L. Eizirik, C. Gysemans, P. Carmeliet, L. Overbergh & C. Mathieu. Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways. Cell Rep 10: 711-25  (2015) (IF = 8.3 ; C =181) PubMed

A. Zecchin, P.C. Stapor, J. Goveia & P. Carmeliet. Metabolic pathway compartmentalization: an underappreciated opportunity? Curr Opin Biotechnol 34: 73-81 (2015) (Review) (IF = 8.0 ; C = 69) PubMed

S. Herkenne, C. Paques, O. Nivelles, M. Lion, K. Bajou, T. Pollenus, M. Fontaine, P. Carmeliet, J.A. Martial, N.Q. Nguyen & I. Struman. The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis. Sci Signal 8(403): ra117 (2015) (IF = 6.3 ; C = 42) PubMed

A. Kuchnio, M. Dewerchin & P. Carmeliet. The PHD2 oxygen sensor paves the way to metastasis. Oncotarget 6: 35149-50 (2015) Editorial (IF = 6.3 ; C = 6) PubMed

K.K. Chereddy, A. Lopes, S. Koussoroplis, V. Payen, C. Moia, H. Zhu, P. Sonveaux, P. Carmeliet, A. des Rieux, G. Vandermeulen & V. Preat. Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds. Nanomedicine 11: 1975-84 (2015) (IF = 5.4 ; C = 99) PubMed

A. Peeters, A.B. Shinde, R. Dirkx, J. Smet, K. De Bock, M. Espeel, I. Vanhorebeek, A. Vanlander, R. Van Coster, P. Carmeliet, M. Fransen, P.P. Van Veldhoven & M. Baes. Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1alpha independent proliferation. Biochim Biophys Acta 1853: 285-98 (2015) (IF = 5.3 ; C = 60) PubMed

J.K. Manesia, Z. Xu, D. Broekaert, R. Boon, A. van Vliet, G. Eelen, T. Vanwelden, S. Stegen, N. Van Gastel, A. Pascual-Montano, S.M. Fendt, G. Carmeliet, P. Carmeliet, S. Khurana & C.M. Verfaillie. Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways. Stem Cell Res 15: 715-21 (2015) (IF = 5.3 ; C = 61) PubMed

J. Kalucka, R. Missiaen, M. Georgiadou, S. Schoors, C. Lange, K. De Bock, M. Dewerchin & P. Carmeliet. Metabolic control of the cell cycle. Cell Cycle 14: 3379-88 (2015) (Review) (IF = 4.5; C = 70) PubMed

A.R. Cantelmo, A. Brajic & P. Carmeliet. Endothelial Metabolism Driving Angiogenesis: Emerging Concepts and Principles. Cancer J 21: 244-9 (2015) (Review) (IF = 4.2 ; C = 31) PubMed

A. Zecchin, G. Borgers & P. Carmeliet. Endothelial cells and cancer cells: metabolic partners in crime? Cur Opin Hematol 22: 234-42 (2015) (Review) (IF = 4.0 ; C = 14) PubMed

L. Lieben, L. Verlinden, R. Masuyama, S. Torrekens, K. Moermans, L. Schoonjans, P. Carmeliet & G. Carmeliet. Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. Bone 81: 502-12 (2015) (IF = 3.9 ; C = 13) PubMed

P. de Zeeuw, B.W. Wong & P. Carmeliet. Metabolic Adaptations in Diabetic Endothelial Cells. Circ J 79: 934-41 (2015) (Review) (IF = 3.6 ; C = 38) PubMed

K.L. Aasa, B. Zavan, R.L. Luna, P.G. Wong, N.M. Ventura, M.Y. Tse, P. Carmeliet, M.A. Adams, S.C. Pang & B.A. Croy. Placental Growth Factor Influences Maternal Cardiovascular Adaptation to Pregnancy in Mice. Biol Reprod 92: 44, 1-10 (2015) (IF = 3.4 ; C = 26) PubMed

S. Vandekeere, M. Dewerchin & P. Carmeliet. Angiogenesis revisited: an overlooked role of endothelial cell metabolism in vessel sprouting. Microcirculation 22: 509-17 (2015) (Review) (IF = 2.5 ; C = 94) PubMed

B. Ghesquière, B. Wong, A. Kuchnio & P. Carmeliet. Metabolism of stromal and immune cells in health and disease. Nature 511: 167-76 (2014) (Review) (IF = 42.3 ; C = 351). PubMed

F. De Smet, A. Christopoulos & P. Carmeliet, Allosteric targeting of receptor tyrosine kinases. Nat Biotechnol 32: 1113-20 (2014) (IF = 32.4). PubMed

H. Maes, A. Kuchnio, A. Peric, S. Moens, K. Nys, K. De Bock, A. Quaegebeur, S. Schoors, M. Georgiadou, J. Wouters, S. Vinckier, H. Vankelecom, M. Garmyn, A. C. Vion, F. Radtke, C. Boulanger, H. Gerhardt, E. Dejana, M. Dewerchin, B. Ghesquiere, W. Annaert, P. Agostinis & P. Carmeliet. Tumor vessel normalization by chloroquine independent of autophagy. Cancer Cell 26: 190-206 (2014) (IF = 28.1 ; C = 332) (highlighted by (inter)-national press). PubMed

K. Bajou, S. Herkenne, V. L. Thijssen, S. D'Amico, N. Q. Nguyen, A. Bouche, S. Tabruyn, M. Srahna, J. Y. Carabin, O. Nivelles, C. Paques, I. Cornelissen, M. Lion, A. Noel, A. Gils, S. Vinckier, P. J. Declerck, A. W. Griffioen, M. Dewerchin, J. A. Martial, P. Carmeliet & I. Struman. PAI-1 mediates the antiangiogenic and fibrinolytic activity of 16K prolactin. Nat Med 7: 741-7 (2014) (IF = 24.3 ; C = 79) PubMed

S. Schoors, K. De Bock, A. R. Cantelmo, M. Georgiadou, B. Ghesquière, S. Cauwenberghs, A. Kuchnio, B.W. Wong, A. Quaegebeur, J. Goveia, F. Bifari, X. Wang, R. Blanco, B. Tembuyser, I. Cornelissen, A. Bouche, S. Vinckier, S. Diaz-Moralli, H. Gerhardt, S. Telang, M. Cascante, J. Chesney, M. Dewerchin & P. Carmeliet. Partial and transient reduction of glycolysis by PFKFB3-blockade reduces pathological angiogenesis. Cell Metab 19: 37-48 (2014) (IF = 13.7 ; C = 415) PubMed

H. Maes, A. Kuchnio, P. Carmeliet & P. Agostinis. How to teach an old dog new tricks: Autophagy-independent action of chloroquine on the tumor vasculature. Autophagy 10: 2082-4 (2014) (IF = 11.4 ; C = 16) PubMed

J. Goveia, A. Zecchin, F.M. Rodriguez, S. Moens, P.C. Stapor & P. Carmeliet. Endothelial cell differentiation by SOX17: promoting the tip cell or stalking its neighbor instead? Circ Res 115: 205-7 (2014) (Comment Editorial) (IF = 11.1 ; C = 10) PubMed

A.T. Henze, B.K. Garvalov, S. Seidel, A.M. Cuesta, M. Ritter, A. Filatova, F. Foss, H. Dopeso, C.L. Essmann, P.H. Maxwell, G. Reifenberger, P. Carmeliet, A. Acker-Palmer & T. Acker. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 5: 5582 (2014) (IF = 10.7 ; C= 58) PubMed

M. Manetti, I. Rosa, A.F. Milia, S. Guiducci, P. Carmeliet, L. Ibba-Manneschi & M. Matucci-Cerinic. Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma? Ann Rheum Dis 73: 1700-9 (2014) (IF = 9.1 ; C = 69) PubMed

D. Laoui, E. Van Overmeire, G. Di Conza, C. Aldeni, J. Keirsse, Y. Morias, K. Movahedi, I. Houbracken, E. Schouppe, Y. Elkrim, O. Karroum, B. Jordan, P. Carmeliet, C. Gysemans, P. De Baetselier, M. Mazzone & J.A. Van Ginderachter. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res 74: 24-30 (2014) (IF = 8.6 ; C = 330) PubMed

F. Morfoisse, A. Kuchnio, C. Frainay, A. Gomez-Brouchet, MB Delisle, S. Marzi, A. C. Helfer, F. Hantelys, F. Pujol, J. Guillermet-Guibert, C. Bousquet, M. Dewerchin, S. Pyronnet, A.C. Prats, P. Carmeliet & B. Garmy-Susini. Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1alpha-independent translation-mediated mechanism. Cell Rep 6: 155-67 (2014) (IF = 8.3 ; C = 98) PubMed

G. Mountzios, G. Pentheroudakis & P. Carmeliet. Bevacizumab and micrometastases: Revisiting the preclinical and clinical rollercoaster. Pharmacol Ther 141: 117-24 (2014) (Review) (IF = 7.8 ; C = 37) PubMed

J. Goveia, P.C. Stapor & P. Carmeliet. Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease. EMBO Mol Med 6: 1105-20 (2014) (Review) (IF = 7.8 ; C = 149) PubMed

F. De Smet, B. Tembuyser, A. Lenard, F. Claes, J. Zhang, C. Michielsen, A. Van Schepdael, J.M. Herbert, F. Bono, M. Affolter, M. Dewerchin & P. Carmeliet. Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity. Chem Biol  21: 1310-7 (2014) (IF = 6.6 ; C = 32) PubMed

S.B. Oh, C.J. Byun, J.H. Yun, D.G. Jo, P. Carmeliet, J.Y. Koh & J.Y. Lee. Tissue plasminogen activator arrests Alzheimer's disease pathogenesis. Neurobiol Aging 35: 511-9 (2014) (IF = 6.2 ; C = 36) PubMed

S. Bobic, V. Hox, I. Callebaut, S. Vinckier, B. Jonckx, J.M. Stassen, M. Jorissen, P. Gevaert, P. Carmeliet, C. Bachert, J.L. Ceuppens & P.W. Hellings. Vascular endothelial growth factor receptor 1 expression in nasal polyp tissue. Allergy 69: 237-45 (2014) (IF = 5.9 ; C = 13) PubMed

P.C. Stapor, X. Wang, J. Goveia, S. Moens & P. Carmeliet. Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism. J. Cell Sci 127: 4331-41 (2014) (Review) (IF = 5.9 ; C = 72) PubMed

S. Moens, J. Goveia, P.C. Stapor, A.R. Cantelmo & P. Carmeliet. The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses. Cytokine Growth Factor Rev 25: 473-82 (2014) (Review) (IF = 5.4 ; C = 111) PubMed

S. Schoors; A.R. Cantelmo, M. Georgiadou, P. Stapor, X. Wang, A. Quaegebeur, S. Cauwenberghs, B.W. Wong, F. Bifari, I. Decimo, L. Schoonjans, K. De Bock, M. Dewerchin & P. Carmeliet. Incomplete and transitory decrease of glycolysis: A new paradigm for anti-angiogenic therapy? Cell Cycle 13:16-22 (2014) (IF = 5.3 ; C = 47) PubMed

D. Lambrechts, M. Moisse, P. Delmar, D.W. Miles, N. Leighl, B. Escudier, E. Van Cutsem, A.T. Bansal, P. Carmeliet, S.J. Scherer, S. de Haas & C. Pallaud. Genetic markers of bevacizumab-induced hypertension. Angiogenesis 17: 685-94 (2014) (IF = 4.8 ; C = 25) PubMed

S. de Haas, P. Delmar, A.T. Bansal, M. Moisse, D.W. Miles, N. Leighl, B. Escudier, E. Van Cutsem, P. Carmeliet, S.J. Scherer, C. Pallaud & D. Lambrechts. Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy. Angiogenesis 17: 909-20 (2014) (IF = 4.8 ; C = 41) PubMed

C. d'Audigier, B. Gautier, A. Yon, J. M. Alili, C. L. Guerin, S. M. Evrard, A. Godier, S. Haviari, M. Reille-Serroussi, F. Huguenot, B. Dizier, N. Inguimbert, D. Borgel, I. Bieche, C. Boisson-Vidal, C. Roncal, P. Carmeliet, M. Vidal, P. Gaussem & D.M. Smadja. Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential. Angiogenesis 17: 603-16 (2014) (IF = 4.8 ; C = 13) PubMed

P. Leroux, P.L. Omouendze, V. Roy, N. Dourmap, B.J. Gonzalez, C. Brasse-Lagnel, P. Carmeliet, I. Leroux-Nicollet & S. Marret. Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice. J Neuropathol Exp Neurol 73: 387-402 (2014) (IF = 4.3 ; C = 9) PubMed

M. Dewerchin & P. Carmeliet. Placental growth factor in cancer. Expert Opin Ther Targets 18:  1339-54 (2014) (Review) (IF = 4.1 ; C = 60) PubMed

C. Rico, A. Dodelet-Devillers, M. Paquet, M. Tsoi, E. Lapointe, P. Carmeliet & D. Boerboom. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival in mice. Biol Reprod 90: 135-9 (2014) (IF = 3.4 ; C = 45) PubMed

M.T. Ratsep, P. Carmeliet, M.A. Adams & B.A. Croy. Impact of placental growth factor deficiency on early mouse implant site angiogenesis. Placenta 35: 772-5 (2014) (IF = 3.3 ; C = 30) PubMed

A. des Rieux, P. De Berdt, E. Ansorena, B. Ucakar, J. Damien, O. Schakman, E. Audouard, C. Bouzin, D. Auhl, T. Simon-Yarza, O. Feron, M.J. Blanco-Prieto, P. Carmeliet, C. Bailly, F. Clotman & V. Preat. Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord. J Biomed Mater Res Part A 102: 2345-55 (2014) (IF = 2.8 ; C = 48) PubMed

D. Verdegem, S. Moens, P. Stapor & P. Carmeliet. Endothelial cell metabolism: parallels and divergences with cancer cell metabolism. Cancer Metab 2: 19 (2014) (Review) (IF = N/A ; C = 92) PubMed

K. De Bock, M. Georgiadou, S. Schoors, A. Kuchnio, B.W. Wong, A.R. Cantelmo, A. Quaegebeur, B. Ghesquière, S. Cauwenberghs, G. Eelen, L.K. Phng, I Betz, B. Tembuyser, K. Brepoels, J. Welti, I.Geudens, I. Segura, B. Cruys, F. Bifari, I.Decimo, R. Blanco, S. Wyns, J. Vangindertael, S. Rocha, R. Collins, S. Munck , D. Daelemans, H. Imamura, R. Devlieger, M. Rider, P. P. Van Veldhoven, F. Schuit, R. Bartrons, J. Hofkens, P. Fraisl, S. Telang, R. J. DeBerardinis, L. Schoonjans, S. Vinckier, J. Chesney, H. Gerhardt, M. Dewerchin & P. Carmeliet. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell 154: 651-63 (2013) (IF = 34.8 ; C = 1,007). (Highlighted by featured editorials in Nature, Science, Nature Rev Cell Mol Biol, Embo Mol Med, Cell Cycle, and by national and international press). PubMed

M. Snuderl, A. Batista, N. D. Kirkpatrick, C. Ruiz de Almodovar, L. Riedemann, E. C. Walsh, R. Anolik, Y. Huang, J. D. Martin, W. Kamoun, E. Knevels, T. Schmidt, C. T. Farrar, B. J. Vakoc, N. Mohan, E. Chung, S. Roberge, T. Peterson, B. H. Zhelyazkova, S. Yip, M. Hasselblatt, C. Rossig, E. Niemeyer, N. Ferrara, M. Klagsbrun, D. G. Duda, D. Fukumura, L. Xu, P. Carmeliet & R. K. Jain. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152: 1065-76 (2013) (IF = 34.8 ; C = 200) (highlighted by (inter)-national press). PubMed

F. Bono, F. De Smet, C. Herbert, K. De Bock, M. Georgiadou, P. Fons, M. Tjwa, C. Alcouffe, A. Ny, M. Bianciotto, B. Jonckx, M. Murakami, A. Lanahan, C. Michielsen, D. Sibrac, F. Dol-Gleizes, M. Mazzone, S. Zacchigna, J. P. Herault, C. Fischer, P. Rigon, C. Ruiz de Almodovar, F. Claes, I. Blanc, K. Poesen, J. Zhang, I. Segura, G. Gueguen, M. F. Bordes, D. Lambrechts, R. Broussy, M. van de Wouwer, C. Michaux, T. Shimada, I. Jean, S. Blacher, A. Noel, P. Motte, E. Rom, J. M. Rakic, S. Katsuma, P. Schaeffer, A. Yayon, A. Van Schepdael, H. Schwalbe, F. Gervasio, G. Carmeliet, J. Rozensky, M. Dewerchin, M. Simons, A. Christopoulos, J. M. Herbert & P. Carmeliet. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell 23: 477-88 (2013) (IF = 28.2 ; C = 144) (Highlighted by featured editorials in Nature SciBX ((Science Business exchange)), Nat Chem Biol and Cancer Discovery). PubMed

C. Herbert, U. Schieborr, K. Saxena, J. Juraszek, F. De Smet, C. Alcouffe, M. Bianciotto, G. Saladino, D. Sibrac, D. Kudlinzki, S. Sreeramulu, A. Brown, P. Rigon, JP. Herault, G. Lassalle, T.L. Blundell, F. Rousseau, A. Gils^{^}, J. Schymkowitz, P. Tompa, J.M. Herbert, P. Carmeliet, F. L. Gervasio, H. Schwalbe & F. Bono. Molecular mechanism of SSR128129E, an extracellularly acting small-molecule allosteric inhibitor of FGF receptor signaling. Cancer Cell 23: 489-501 (2013) (IF = 28.2 ; C = 107) Highlighted by featured editorials in Nature SciBX (Science Business exchange), Nat Chem Biol and Cancer Discovery). PubMed

D. Lambrechts, H. J. Lenz, S. de Haas, P. Carmeliet & S. J. Scherer. Markers of response for the antiangiogenic agent bevacizumab. J Clin Oncol 31: 1219-30 (2013) (Review) (IF = 18.4 ; C = 282)  PubMed

F. Langlet, BE. Levin, SS Luquet, M. Mazonne, A. Messina, AA. Dunn-Meynell, E Balland, A. Lacombe, D. Mazur, P. Carmeliet, SG. Bouret, V. Prevot &B.Dehouck. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting . Cell Metab 17: 607-17 (2013) (IF = 13.7 ; C = 252) PubMed

K. De Bock, M. Georgiadou & P. Carmeliet. Role of endothelial cell metabolism in vessel sprouting. Cell Metab 18: 634-47 (2013) (Review) (IF = 13.7 ; C = 297). PubMed

K. Khoufache, F. Berri, W. Nacken, A. B. Vogel, M. Delenne, E. Camerer, S. R. Coughlin, P. Carmeliet, B. Lina, G. F. Rimmelzwaan, O. Planz, S. Ludwig & B. Riteau. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest 123: 206-14 (2013) (IF = 13.1 ; C = 81) PubMed

F. Van Hauwermeiren, M. Armaka, N. Karagianni, K. Kranidioti, R.E. Vandenbroucke, S. Loges, M. Van Roy, J. Staelens, L. Puimege, A. Palagani, W.V. Berghe, P. Victoratos, P. Carmeliet, C. Libert & G. Kollias. Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest 123: 2590-603 (2013) (IF = 13.1 ; C = 90) PubMed

J. Welti, S. Loges, S. Dimmeler & P. Carmeliet. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J Clin Invest 123: 3190-200 (Invited review) (IF = 13.1 ; C =527) PubMed

S. Coulon, V. Legry, F. Heindryckx, C. Van Steenkiste, C. Casteleyn, K. Olievier, L. Libbrecht, P. Carmeliet, B. Jonckx, J. M. Stassen, H. Van Vlierberghe, I. Leclercq, I. Colle & A. Geerts. Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models. Hepatology 57: 1793-805 (2013) (IF = 11.7 ; C = 70) PubMed

B. W. Wong, A. Kuchnio, U. Bruning & P. Carmeliet. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. Trends Biochem Sci 1: 3-11 (2013) (Review) (IF = 10.8 ; C = 114) PubMed

D. Vanhoutte, G. C. van Almen, L. N. Van Aelst, J. Van Cleemput, W. Droogne, Y. Jin, F. Van de Werf, P. Carmeliet, J. Vanhaecke, A. P. Papageorgiou & S. Heymans. Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection. Eur Heart 34: 1930-41 (2013) (IF = 10.5 ; C = 26) PubMed

M. Martin, I. Geudens, J. Bruyr, M. Potente, A. Bleuart, M. Lebrun, N. Simonis, C. Deroanne, J.C. Twizere, P. Soubeyran, P. Peixoto, D. Mottet, V. Janssens, W.K. Hofmann, F. Claes, P. Carmeliet, R. Kettmann, H. Gerhardt & F. Dequiedt. PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. Embo J 32: 2491-503 (2013) (IF = 9.8 ; C = 38) PubMed

K. Arndt, T. Grinenko, N. Mende, D. Reichert, M. Portz, T. Ripich, P. Carmeliet, D. Corbeil & C. Waskow. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc Natl Acad Sci U S A 110: 5582-87 (2013) (IF = 9.7 ; C = 48) PubMed

F. Heindryckx, S. Coulon, E. Terrie, C. Casteleyn, J. M. Stassen, A. Geerts, L. Libbrecht, J. Allemeersch, P. Carmeliet, I. Colle & H. Van Vlierberghe. The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model. J Hepatol 58: 319-28 (2013) (IF = 9.3 ; C = 24) PubMed

F. Berri, G.F. Rimmelzwaan, M. Hanss, E. Albina, M.L. Foucault-Grunenwald, V.B. Le, S.E. Vogelzang-van Trierum, P. Gil, E. Camerer, D. Martinez, B. Lina, R. Lijnen, P. Carmeliet & B. Riteau. Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. PLoS Path 9 pii: e1003229 (2013) (IF = 9.1 ; C = 66) PubMed

I. Ben-Batalla, A. Schultze, M. Wroblewski, R. Erdmann, M. Heuser, J.S. Waizenegger, K. Riecken, M. Binder, D. Schewe, S. Sawall, V. Witzke, M. Cubas-Cordova, M. Janning, J. Wellbrock, B. Fehse, C. Hagel, J. Krauter, A. Ganser, J.B. Lorens, W. Fiedler, P. Carmeliet, K. abPantel, C. Bokemeyer & S. Loges. Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood 122: 2443-52 (2013) (IF = 9.1 ; C = 184) PubMed

G. Eelen, B. Cruys, J. Welti, K. De Bock & P. Carmeliet. Control of vessel sprouting by genetic and metabolic determinants. Trends Endocrin Metab 24: 589-96 (2013) (Review) (IF = 8.9 ; C = 49). PubMed

R. Luca, M. Averna, F. Zalfa, M. Vecchi, F. Bianchi, G. La Fata, F. Del Nonno, R. Nardacci, M. Bianchi, P. Nuciforo, S. Munck, P. Parrella, R. Moura, E. Signori, R. Alston, A. Kuchnio, M. G. Farace, V. M. Fazio, M. Piacentini, B. De Strooper, T. Achsel, G. Neri, P. Neven, D. G. Evans, P. CARMELIET, M. Mazzone & C. Bagni. The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis. EMBO Mol Med 5: 1523-36 (2013) (IF = 7.8 ; C = 94) PubMed

T. L. Walker, A. Wierick, A. M. Sykes, B. Waldau, D. Corbeil, P. Carmeliet & G. Kempermann. Prominin-1 Allows Prospective Isolation of Neural Stem Cells from the Adult Murine Hippocampus. J Neurosci 33(7): 3010-24 (2013) (IF = 7.1 ; C = 51) PubMed

P. Carmeliet & C.R. de Almodovar. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci 70: 1763-78 (2013) (Review) (IF = 6.6 ; C = 135) PubMed

S. Verheijden, A. Bottelbergs, O. Krysko, D.V. Krysko, L. Beckers, S. De Munter, P.P. Van Veldhoven, S. Wyns, W. Kulik, K.A. Nave, M.S. Ramer, P. Carmeliet, C.M. Kassmann & M. Baes. Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation. Neurobiol Dis 58: 258-69 (2013) (IF = 5.6 ; C = 38) PubMed

V. J. Henry, M. Lecointre, V. Laudenbach, C. Ali, R. Macrez, A. Jullienne, V. Berezowski, P. Carmeliet, D. Vivien, S. Marret, B. J. Gonzalez & P. Leroux. High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate. Neurobiol Dis 50: 201-8 (2013) (IF = 5.4 ; C = 21) PubMed

A. Lelli, A. Gervais, C. Colin, C. Cheret, C. Ruiz de Almodovar, P. Carmeliet, K.H. Krause, S. Boillee & M. Mallat. The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Glia 61: 1542-55 (2013) (IF = 5.1 ; C = 41) PubMed

H. Kalakech, S. Tamareille, S. Pons, D. Godin-Ribuot, P. Carmeliet, A. Furber, V. Martin, A. Berdeaux, B. Ghaleh & F. Prunier. Role of hypoxia inducible factor-1alpha in remote limb ischemic preconditioning. J Mol Cel Cardiol 65C: 98-104 (2013) (IF = 5.1 ; C = 55) PubMed

R. Quintens, S. Singh, K. Lemaire, K. De Bock, M. Granvik, A. Schraenen, I.O. Vroegrijk, V. Costa, P. Van Noten, D. Lambrechts, S. Lehnert, L. Van Lommel, L. Thorrez, G. De Faudeur, J.A. Romijn, J.M. Shelton, L. Scorrano, H.R. Lijnen, P.J. Voshol, P. Carmeliet, P.P. Mammen & F. Schuit. Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PloS one 8: e56719 (2013) (IF = 3.5 ; C = 53) PubMed

P.L. Omouendze, V.J. Henry, B. Porte, N. Dupre, P. Carmeliet, B.J. Gonzalez, S. Marret & P. Leroux. Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels. PloS one 8: e71263 (2013) (IF = 3.5 ; C  = 14) PubMed

A. Verheyen, E. Peeraer, D. Lambrechts, K. Poesen, P. Carmeliet, M. Shibuya, I. Pintelon, J.P. Timmermans, R. Nuydens & T. Meert. Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies. Neuroscience 244: 77-89 (2013) (IF = 3.4 ; C = 53) PubMed

A. McGraw, J. Bagley, W. S. Chen, C. Galayda, H. Nickerson, A. Armani, M. Caprio, P. Carmeliet & I. Jaffe. Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. J Am Heart Assoc 2: e000018 (2013) (IF = 2.8 ; C = 91) PubMed

A. Ny, W. Vandevelde, P. Hohensinner, M. Beerens, I. Geudens, A. Diez-Juan, K. Brepoels, S. Plaisance, P.A. Krieg, T. Langenberg, S. Vinckier, A. Luttun, P. Carmeliet & M. Dewerchin. A transgenic Xenopus laevis reporter model to study lymphangiogenesis. Biol Open 2: 882-90 (2013) (IF = 2.4 ; C = 10) PubMed

P. Carmeliet & B. De Strooper. Alzheimer's disease: A breach in the blood-brain barrier. Nature 485: 451-2 (2012) (News and Views) (IF = 36.1 ; C = 23) PubMed

R. K. Jain & P. Carmeliet. SnapShot: Tumor Angiogenesis. Cell 149(6): 1408 e1401 (2012) (IF = 32.4 ; C = 121) PubMed

R. Leite de Oliveira, S. Deschoemaeker, A. T. Henze, K. Debackere, V. Finisguerra, Y. Takeda, C. Roncal, D. Dettori, E. Tack, Y. Jonsson, L. Veschini, A. Peeters, A. Anisimov, M. Hofmann, K. Alitalo, M. Baes, J. D'Hooge, P. Carmeliet & M. Mazzone. Gene-targeting of PHD2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell 22: 263-77 (2012) (IF = 26.6 ; C = 107) PubMed

D. Lambrechts, B. Claes, P. Delmar, J. Reumers, M. Mazzone, B. T. Yesilyurt, R. Devlieger, C. Verslype, S. Tejpar, H. Wildiers, S. de Haas, P. Carmeliet, S. J. Scherer & E. Van Cutsem. VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol 13: 724-33 (2012) (IF = 17.8 ; C = 162) PubMed

P. Carmeliet, B.W. Wong & K. De Bock. Treating diabetes by blocking a vascular growth factor. Cell metabolism 5: 553-5 (2012) (Preview) (IF = 13.7 ; C = 10) PubMed

B. Detry, C. Erpicum, J. Paupert, S. Blacher, C. Maillard, F. Bruyere, H. Pendeville, T. Remacle, V. Lambert, C. Balsat, S. Ormenese, F. Lamaye, E. Janssens, L. Moons, D. Cataldo, F. Kridelka, P. Carmeliet, M. Thiry, J. M. Foidart, I. Struman & A. Noel. Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase. Blood 119: 5048-56 (2012) (IF = 10.6 ; C = 80) PubMed

Y. Qi, X. Tian, J. Liu, Y. Han, A. M. Graham, M. C. Simon, J. M. Penninger, P. Carmeliet & S. Li. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol 198: 103-14 (2012) (IF = 10.3 ; C = 29) PubMed

O. Guardiola, P. Lafuste, S. Brunelli, S. Iaconis, T. Touvier, P. Mourikis, K. De Bock, E. Lonardo, G. Andolfi, A. Bouche, G. L. Liguori, M. M. Shen, S. Tajbakhsh, G. Cossu, P. Carmeliet & G. Minchiotti. Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. Proc Natl Acad Sci U S A 47: E3231-40 (2012) (IF = 9.7 ; C = 40) PubMed

A. Verheyen, E. Peeraer, R. Nuydens, J. Dhondt, K. Poesen, I. Pintelon, A. Daniels, J. P. Timmermans, T. Meert, P. Carmeliet & D. Lambrechts. Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy. Brain 135: 2629-41 (2012) (IF = 9.5 ; C = 47) PubMed

M. F. Corsten, A. Papageorgiou, W. Verhesen, P. Carai, M. Lindow, S. Obad, G. Summer, S. L. Coort, M. Hazebroek, R. van Leeuwen, M. J. Gijbels, E. Wijnands, E. A. Biessen, M. P. De Winther, F. R. Stassen, P. Carmeliet, S. Kauppinen, B. Schroen & S. Heymans. MicroRNA profiling Identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res 111: 415-25 (2012) (IF = 9.5 ; C = 181) PubMed

F. Heindryckx, A. Kuchnio, C. Casteleyn, S. Coulon, K. Olievier, I. Colle, A. Geerts, L. Libbrecht, P. Carmeliet & H. Van Vlierberghe. Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice. J Hepatol 57: 61-8 (2012) (IF = 9.3 ; C = 19) PubMed

N. van Gastel, S. Torrekens, S. J. Roberts, K. Moermans, J. Schrooten, P. Carmeliet, A. Luttun, F. P. Luyten & G. Carmeliet. Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells. Stem Cells 30: 2460-71 (2012) (IF = 7.8 ; C = 88) PubMed

A. P. Papageorgiou, M. Swinnen, D. Vanhoutte, T. Vandendriessche, M. Chuah, D. Lindner, W. Verhesen, B. de Vries, J. D'Hooge, E. Lutgens, D. Westermann, P. Carmeliet & S. Heymans. Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells. Cardiovasc Res 94: 115-24 (2012) (IF = 6.1 ; C = 54) PubMed

Y. Jung, Y. Shiozawa, J. Wang, N. McGregor, J. Dai, S. I. Park, J. E. Berry, A. M. Havens, J. Joseph, J. K. Kim, L. Patel, P. Carmeliet, S. Daignault, E. T. Keller, L. K. McCauley, K. J. Pienta & R. S. Taichman. Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia 14: 429-39 (2012) (IF = 5.9 ; C = 47) PubMed

J. Kiss, M. Mollenhauer, S. R. Walmsley, J. Kirchberg, P. Radhakrishnan, T. Niemietz, J. Dudda, G. Steinert, M. K. Whyte, P. Carmeliet, M. Mazzone, J. Weitz & M. Schneider. Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis. J Immunol 189: 1955-65 (2012) (IF = 5.8 ; C = 67) PubMed

M. Dewerchin & P. Carmeliet. PlGF: A Multitasking Cytokine with Disease-Restricted Activity. Cold Spring Harb Perspect Med 2(8) pii: a011056 (2012) (IF = 5.4 ; C = 136) PubMed

A. Carlier, L. Geris, K. Bentley, G. Carmeliet, P. Carmeliet & H. Van Oosterwyck. MOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells. PLoS Comput Biol 10: e1002724 (2012) (IF = 5.2 ; C = 62) PubMed

E. Cho, K. J. Lee, J. W. Seo, C. J. Byun, S. J. Chung, D. C. Suh, P. Carmeliet, J. Y. Koh, J. S. Kim & J. Y. Lee. Neuroprotection by urokinase plasminogen activator in the hippocampus. Neurobiol Dis 46: 215-24 (2012) (IF = 5.1 ; C = 34) PubMed

M. Freitas-Andrade, P. Carmeliet, C. Charlebois, D. B. Stanimirovic & M. J. Moreno. PlGF knockout delays brain vessel growth and maturation upon systemic hypoxic challenge. J Cereb Blood Flow Metab 32: 663-75 (2012) (IF = 4.5 ; C = 34) PubMed

S. Bobic, S. Seys, V. De Vooght, I. Callebaut, V. Hox, C. Dooms, S. Vinckier, B. Jonckx, J. M. Saint-Remy, J. M. Stassen, D. M. Bullens, J. L. Ceuppens, P. Carmeliet & P. W. Hellings. Placental Growth Factor Contributes to Bronchial Neutrophilic Inflammation and Edema in Allergic Asthma. Am J Respir Cell Mol Biol 46: 781-9 (2012) (IF = 4.4 ; C = 18) PubMed

L. Nikitidou, I. Kanter-Schlifke, J. Dhondt, P. Carmeliet, D. Lambrechts & M. Kokaia. VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures. PLoS One 7: e40535 (2012) (IF = 4.1 ; C = 20) PubMed

K. Martens, A. Bottelbergs, A. Peeters, F. Jacobs, M. Espeel, P. Carmeliet, P. P. Van Veldhoven & M. Baes. Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone. Mol Genet Metab 4: 735-47 (2012) (IF = 3.2 ; C = 17) PubMed

K. S. Rohrberg, R. K. Olesen, P. Pfeiffer, M. Ladekarl, H. Pappot, I. J. Christensen, G. Hoyer-Hansen, M. Sorensen, B. G. Skov, I. Buysschaert, P. Carmeliet & U. Lassen. Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers. Acta Oncol 51: 234-42 (2012) (IF = 3.1 ; C = 9) PubMed

1. F. Heindryckx, E. Bogaerts, S.H. Coulon, H. Devlies, A.M. Geerts, L. Libbrecht, J.M. Stassen, P. Carmeliet, I.O. Colle & H.R. Van Vlierberghe. Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model. Eur J Gastroenterol Hepatol 24: 1020-32 (2012) (IF = 2.1 ; C = 14) PubMed

H. K. Eltzschig & P. Carmeliet. Hypoxia and Inflammation. New Engl J Med 364: 656-65 (2011) (Review) (IF = 53.4 ; C = 1,561) PubMed

P. Carmeliet & R.K. Jain. Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298-307 (2011) (Review) (IF = 36.1, C = 4,276) PubMed

B. Beck, G. Driessens, S. Goossens, K. K. Youssef, A. Kuchnio, A. Caauwe, P. A. Sotiropoulou, S. Loges, G. Lapouge, A. Candi, G. Mascre, B. Drogat, S. Dekoninck, J. J. Haigh, P. Carmeliet & C. Blanpain. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 478: 399-403 (2011) (IF = 36.1 ; C = 393) PubMed

M. Potente, H. Gerhardt & P. Carmeliet. Basic and therapeutic aspects of angiogenesis. Cell 146: 873-87 (2011) (Review) (IF = 34.9 ; C = 2,203) PubMed

P. Carmeliet & R.K. Jain. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10: 417-27 (2011) (Review) (IF = 28.7 ; C = 1,314) PubMed

C. Rolny°, M. Mazzone°, S. Tugues, D. Laoui, I. Johansson, C. Coulon, M. L. Squadrito, I. Segura, X. Li, E. Knevels, S. Costa, S. Vinckier, T. Dresselaer, P. Akerud, M. De Mol, H. Salomaki, M. Phillipson, S. Wyns, E. Larsson, I. Buysschaert, J. Botling, U. Himmelreich, J. A. Van Ginderachter, M. De Palma, M. Dewerchin, L. Claesson-Welsh & P. Carmeliet. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell 19: 31-44 (2011) (IF = 26.9 ; C = 615) PubMedT. Schmidt°, B. Kharabi Masouleh°, S. Loges°, S. Cauwenberghs, P. Fraisl, C. Maes, B. Jonckx, K. De Keersmaecker, M. Kleppe, M. Tjwa, T. Schenk, S. Vinckier, R. Fragoso, M. De Mol, K. Beel, S. Dias, C. Verfaillie, R.E. Clark, T.H. Brümmendorf, P. Vandenberghe, S. Rafii, T. Holyoake, A. Hochhaus, J. Cools, M. Karin, G. Carmeliet, M. Dewerchin & P. Carmeliet. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.  Cancer Cell 19: 740-53 (2011) (IF = 26.9 ; C = 115) PubMed

J. Adam, E. Hatipoglu, L. O’Flaherty, N. Ternette, N. Sahgal, H. Lockstone, D. Baban, E. Nye, G. W. Stamp, K. Wolhuter, M. Stevens, R. Fischer, P. Carmeliet, P. H. Maxwell, C. W. Pugh, N. Frizzell, T.Soga, B. M. Kessler, M. El-Bahrawy, P. J. Ratcliffe & P. J. Pollard. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: role of Nrf2 signaling and fumarate mediated succination of KEAP1. Cancer Cell 20: 524-37 (2011) (IF = 26.9 ; C = 544) PubMed

E. Van Cutsem, D. Lambrechts, H. Prenen, R.K. Jain & P. Carmeliet. Lessons from the adjuvant bevacizumab trial on colon cancer: what next? J Clin Oncol 29: 1-4 (2011) (Editorial) (IF = 19.9). PubMed

N. Takahashi, T. Kuwaki, S. Kiyonaka, T. Numata, D. Kozai, Y. Mizuno, S. Yamamoto, S. Naito, E. Knevels, P. Carmeliet,  T. Oga, S. Kaneko, S. Suga, T. Nokami, J. Yoshida & Y. Mori. TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol 7: 701-11 (2011) (IF = 15.8 ; C = 225) PubMed

E. Storkebaum, A. Quaegebeur, M. Vikkula & P. Carmeliet. Cerebrovascular disorders: molecular insights and therapeutic opportunities. Nat Neurosci 14: 1390-7 (2011) (Review) (IF = 14.2 ; C = 80) PubMed

S. R. Walmsley, E. R. Chilvers, A. A. Thompson, K. Vaughan, H. M. Marriott, L. C. Parker, G. Shaw, S. Parmar, M. Schneider, I. Sabroe, D. H. Dockrell, M. Milo, C. T. Taylor, R. S. Johnson, C. W. Pugh, P. J. Ratcliffe, P. H. Maxwell, P. Carmeliet & M. K. Whyte. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest 121: 1053-63 (2011) (IF = 14.1 ; C = 145) PubMed

C. Ruiz de Almodovar, P.J. Fabre, E. Knevels, C. Coulon, I. Segura, P.C. Haddick, L. Aerts, N. Delattin, G. Strasser, W.J. Oh, C. Lange, S. Vinckier, J. Haigh, C. Fouquet, C. Gu, K. Alitalo, V. Castellani, M. Tessier-Lavigne, A. Chedotal, F. Charron & P. Carmeliet. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron 70: 966-78. (2011) (IF = 14.0 ; C = 124) PubMed

A. Quaegebeur, C. Lange & P. Carmeliet. The neurovascular link in health and disease: molecular mechanisms and therapeutic implications. Neuron 71: 406-24 (2011) (Review) (IF = 14.0 ; C = 232) PubMed

M. Ghassibe-Sabbagh, L. Desmyter, T. Langenberg, F. Claes, O. Boute, B. Bayet, P. Pellerin, K. Hermans, L. Backx, M.A. Mansilla, S. Imoehl, S. Nowak, K.U. Ludwig, C. Baluardo, M. Ferrian, P.A. Mossey, M. Noethen, M. Dewerchin, G. Francois, N. Revencu, R. Vanwijck, J. Hecht, E. Mangold, J. Murray, M. Rubini, J.R. Vermeesch, H.A. Poirel, P. Carmeliet & M. Vikkula. FAF1, a gene that Is disrupted in cleft palate and has conserved function in zebrafish. Am J Hum Genet 88: 150-61 (2011) (IF = 11.6  C = 52) PubMed

M. Rehn, A. Olsson, K. Reckzeh, E. Diffner, P. Carmeliet, G. Landberg & J. Cammenga. Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche. Blood 118: 1534-43 (2011) (IF = 10.9 ; C = 67) PubMed

C. V. Steenkiste, J. Ribera, A. Geerts, M. Pauta, S. Tugues, C. Casteleyn, L. Libbrecht, K. Olievier, B. Schroyen, H. Reynaert, L. A. van Grunsven, B. Blomme, S. Coulon, F. Heindryckx, M. De Vos, J. M. Stassen, S. Vinckier, J. Altamirano, R. Bataller, P. Carmeliet, H. Van Vlierberghe, I. Colle & M. Morales-Ruiz. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology 53: 1629-40 (2011) (IF = 10.8 ; C = 74) PubMed

K. De Bock, M. Mazzone & P. Carmeliet.  Anti-angiogenic therapy, hypoxia and metastasis: risky liaisons, or not? Nat Rev Clin Oncol 8: 393-404 (2011) (Review) (IF = 10.7 ; C = 249) Pubmed Link

C. Meissirel, C. Ruiz de Almodovar, E. Knevels, C. Coulon, N. Chounlamountri, I. Segura, P. de Rossi, S. Vinckier, K. Anthonis, B. Deléglise, M. de Mol, C. Ali, K. Dassonville, E. Loyens, J. Honnorat, Y. Michotte, V. Rogemond, I. Smolders, T. Voets, D. Vivien, P. Vanden Berghe, L. Van Den Bosch, W. Robberecht, A. Chédotal, S. Oliviero, M. Dewerchin, D. Schmucker, N. Thomasset, P. Salin & P. Carmeliet. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A 108: 13782-7 (2011) (IF = 9.7 ; C = 36) PubMed

F. Accornero, J.H. van Berlo, M.J. Benard, J.N. Lorenz, P. Carmeliet & J.D. Molkentin. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circ Res 109: 272-80 (2011) (IF = 9.5 ; C = 80) PubMed

K. De Bock, S. Cauwenberghs & P. Carmeliet. Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications. Curr Opin Genet Dev 21: 73-9 (2011) (Review) (IF = 9.3 ; C = 161) PubMed

A. Casazza, X. Fu, I. Johansson, L. Capparuccia, F. Andersson, A. Giustacchini, M.L. Squadrito, M.A. Venneri, M. Mazzone, E. Larsson, P. Carmeliet, M. De Palma, L. Naldini, L. Tamagnone & C. Rolny. Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. Arterioscler Thromb Vasc Biol 31: 741-9 (2011) (IF = 7.2 ; C = 101) PubMed

S. Kutschera, H. Weber, A. Weick, F. De Smet, G. Genove, M. Takemoto, C. Prahst, M. Riedel, C. Mikelis, S. Baulande, C. Champseix, P. Kummerer, E. Conseiller, M. C. Multon, M. Heroult, R. Bicknell, P. Carmeliet, C. Betsholtz & H.G. Augustin. Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin. Arterioscler Thromb Vasc Biol 31: 151-9 (2011) (IF = 7.2 ; C = 63) PubMed

G. Wallays, D. Nuyens, R. Silasi-Mansat, J. Souffreau, Z. Callaerts-Vegh, A. Van Nuffelen, L. Moons, R. D’Hooge, F. Lupu, P. Carmeliet, D. Collen & M. Dewerchin. Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol 31: 2881-8 (2011) (IF = 7.2 ; C = 34) PubMed

J. Dhondt, E. Peeraer, A. Verheyen, R. Nuydens, I. Buysschaert, K. Poesen, K. Van Geyte, M. Beerens, M. Shibuya, J.J. Haigh, T. Meert, P. Carmeliet & D. Lambrechts. Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J 25: 1461-73 (2011) (IF = 6.5 ; C = 44) PubMed

A. de Rieux, B. Ucakar, B.P. Mupendwa, D. Colau, O. Feron, P. Carmeliet & V. Preat. 3D systems delivering VEGF to promote angiogenesis for tissue engineering. J Control Release 150: 272-8 (2011) (IF = 6.5 ; C = 110) PubMed

A. Peeters, P. Fraisl, S. van den Berg, E. Ver Loren van Themaat, A. Van Kampen, M. H. Rider, H. Takemori, K. Willems van Dijk, P. P. Van Veldhoven, P. Carmeliet & M. Baes. Carbohydrate metabolism is perturbed in peroxisome deficient hepatocytes due to mitochondrial dysfunction, AMP- activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor {gamma} coactivator 1alpha (PGC-1alpha) suppression. J Biol Chem 286: 42162-79 (2011) (IF = 5.5 ; C = 42) PubMed

G.C. van Almen, M. Swinnen, P. Carai, W. Verhesen, J.P. Cleutjens, J. D'Hooge, F.K. Verheyen, Y.M. Pinto, B. Schroen, P. Carmeliet & S. Heymans. Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. J Mol Cell Cardiol 51: 318-28 (2011) (IF = 5.4 ; C = 42) PubMed

S. Soomro, T. Langenberg , A. Mahringer, V.B. Konkimalla,C. Horwedel, P. Holenya, A. Brand, C. Cetin, G. Fricker, M. Dewerchin, P. Carmeliet, E.M. Conway, H. Jansen & T. Efferth. Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties. J Cell Mol Med 15: 1122-35 (2011) (IF = 5.1 ; C = 47) PubMed

L. Chaballe, P. Close, M. Sempels, S. Delstanche, J. Fanielle, L. Moons, P. Carmeliet, J. Schoenen, A. Chariot & R. Franzen. Involvement of placental growth factor in Wallerian degeneration. Glia 59: 379-96 (2011) (IF = 5.1 ; C = 36) PubMed

H. Iwasaki, A. Kawamoto, M. Tjwa, M. Horii, S. Hayashi, A. Oyamada, T. Matsumoto, S. Suehiro, P. Carmeliet & T. Asahara. PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. PLoS One 6: e24872 (2011) (IF = 4.1 ; C = 53) PubMed

H. Huang, S. Van de Veire, M. Dalal, R. Parlier, RD Semba, P. Carmeliet & S.A. Vinores.  Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. Invest Ophthalmol Vis Sci 52: 7565-73 (2011) (IF = 4.0 ; C = 41) PubMed

S. Labied, S. Blacher, P. Carmeliet, A. Noel, F. Frankenne, J.M. Foidart & C. Munaut. Transient reduction of placental angiogenesis in PAI-1 deficient mice. Physiol Genomics 43: 188-98 (2011) (IF = 3.9 ; C = 16) PubMed

E. Storkebaum & P. Carmeliet. Paracrine control of vascular innervation in health and disease. Acta Physiol 203: 61-86 (2011) (Review) (IF = 3.1 ; C = 26) PubMed

L.H. Anderson, C.A. Boulanger, G.H. Smith, P.Carmeliet  & C.J. Watson. Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland. Dev Dynam 240: 674-81 (2011) (IF = 2.8 ; C = 25) PubMed

T. Schmidt & P. Carmeliet (2011). "Angiogenesis: a target in solid tumors, also in leukemia?". Hematology Am Soc Hematol Educ Program 2011: 1-8 (Review) (IF = N/A ; C = 66) PubMed

S. Van de Veire, T. Van Bergen, E. Vandewalle, P. Carmeliet, L. Moons & I. Stalmans. The role of the VEGF-isoforms in pathological choroidal/retinal angiogenesis. Bull Soc Belge Ophtalmol 55: 317 (2011) (IF = N/A ; C = 1) PubMed

X.L. Aranguren, M. Beerens, W. Vandevelde, M. Dewerchin, P. Carmeliet & A. Luttun. Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. Biochem Biophys Res Commun 410: 121-6 (2011) (IF = N/A ; C = 43) PubMed

T. Schmidt & P. Carmeliet. Blood-vessel formation: Bridges that guide and unite. Nature 465: 697-9 (2010) (News and Views) (IF = 34.5 ; C = 95) PubMed

S. Van de Veire, I. Stalmans, F. Heindryckx, H. Oura, A. Tijeras-Raballand, T. Schmidt, S. Loges, I. Albrecht, B. Jonckx, S. Vinckier, C. Van Steenkiste, S. Tugues, C. Rolny, M. De Mol, D. Dettori, P. Hainaud, L. Coenegrachts, J. O. Contreres, T. Van Bergen, H. Cuervo, W. H. Xiao, C. Le Henaff, I. Buysschaert, B. Kharabi Masouleh, A. Geerts, T. Schomber, P. Bonnin, V. Lambert, J. Haustraete, S. Zacchigna, J. M. Rakic, W. Jimenez, A. Noel, M. Giacca, I. Colle, J. M. Foidart, G. Tobelem, M. Morales-Ruiz, J. Vilar, P. Maxwell, S. A. Vinores, G. Carmeliet, M. Dewerchin, L. Claesson-Welsh, E. Dupuy, H. Van Vlierberghe, G. Chrisofori, M. Mazzone, M. Detmar, D. Collen & P. Carmeliet. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell 141: 178-90 (2010) (IF = 31.3 ; C = 230) PubMed

I.Z. Jaffe, B.G. Newfell, M. Aronovitz, N.N. Mohammad, A.P. McGraw, R.E. Perreault, P. Carmeliet, A. Ehsan & M.E. Mendelsohn. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest 120: 3891-900 (2010) (IF = 15.4).

M. Bry, R. Kivela, T. Holopainen, A. Anisimov, T. Tammela, J. Soronen, J. Silvola, A. Saraste, M. Jeltsch, P. Korpisalo, P. Carmeliet, K.B. Lemstrom, M. Shibuya, S. Yla-Herttuala, L. Alhonen, E. Mervaala, L.C. Andersson, J. Knuuti & K. Alitalo. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation 122: 1725-33 (2010) (IF = 14.8 ; C = 121) PubMed

E. Storkebaum, C. Ruiz de Almodovar, M. Meens, S. Zacchigna, M. Mazzone, G. Vanhoutte, S. Vinckier, K. Miskiewicz, K. Poesen, D. Lambrechts, G. M. J. Janssen, G. E. Fazzi, P Verstreken, J Haigh, P.M. Schiffers, H. Rohrer, A. Van der Linden, J.G.R. De Mey & P. Carmeliet. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor upon vascular endothelial growth factor trap delivery. Circulation 122: 273-81 (2010) (IF = 14.8 ; C = 36) PubMed

A. Quaegebeur, I. Segura & P. Carmeliet. Pericytes: blood-brain barrier safeguards against neurodegeneration? Neuron 68: 321-3 (2010) (Preview) (IF = 13.2 ; C = 80) PubMed

M.M. Tambuwala, E.P. Cummins, C.R. Lenihan, J. Kiss, M. Stauch, C.C. Scholz, P. Fraisl, F. Lasitschka, M. Mollenhauer, S.P. Saunders, P.H. Maxwell, P. Carmeliet, P.G. Fallon, M. Schneider & C.T. Taylor. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology 139: 2093-101 (2010) (IF = 12.9 ; C = 169) PubMed

M. Schneider, K. Van Geyte, P. Fraisl, J. Kiss, J. Aragones, M. Mazzone, H. Mairbaurl, K. De Bock, N. H. Jeoung, M. Mollenhauer, M. Georgiadou, T. Bishop, C. Roncal, A. Sutherland, B. Jordan, B. Gallez, J. Weitz, R. A. Harris, P. Maxwell, M. Baes, P. Ratcliffe & P. Carmeliet. Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. Gastroenterology 138: 1143-54 e1141-42 (2010) (IF = 12.9 ; C = 94) PubMed

A.A. Lanahan, K. Hermans, F. Claes, J. S. Kerley-Hamilton, Z. Zhuang, F. Giordano, P. Carmeliet & M. Simons. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 18: 713-24 (2010) (IF = 12.8 ; C = 220) PubMed

P. Saharinen, H. Helotera, J. Miettinen, C. Norrmen, G. D’Amico, M. Jeltsch, T. Langenberg, W. Vandevelde, A. Ny, M. Dewerchin, P. Carmeliet & K. Alitalo. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulate lymphatic vessel development. Genes Dev 24: 875-80 (2010) (IF = 12.0). PubMed

K. Hermans, F. Claes, W. Vandevelde, W. Zheng, I. Geudens, F. Orsenigo, F. De Smet, E. Gjini, K. Anthonis, B. Ren, D. Kerjaschki, M. Autiero, A. Ny, M. Simons, M. Dewerchin, S. Schulte-Merker, E. Dejana, K. Alitalo & P. Carmeliet. Role of synectin in lymphatic development in zebrafish and frogs. Blood 116: 3356-66 (2010) (IF = 10.9 ; C = 38). PubMed

S. Loges, T. Schmidt, M. Tjwa, K. Van Geyte, D. Lievens, E. Lutgens, D. Vanhoutte, D. Borgel, S. Plaisance, M. Hoylaerts, A. Luttun, M. Dewerchin, B. Jonckx & P. Carmeliet. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood 115: 2264-73 (2010) (IF = 10.9 ; C = 148) PubMed

L. Burnier, F. Saller, L. Kadi, A.C. Brisset, R. Sugamele, L. Baudino, F. Bono, J.M. Herbert, P. Carmeliet, M. Schapira, S. Izui & A. Angelillo-Scherrer. Gas6 deficiencey in recipient mice of allogeneic transplantation alleviates hepatic graft-versus-host disease. Blood 115: 3390-7 (2010) (IF = 10.9 ; C = 11) PubMed

C. Maes, S. Goossens, S. Bartunkova, B. Drogat, L. Coenegrachts, I. Stockmans, K. Moermans, O. Nyabi, K. Haigh, M. Naessens, L. Haenebalcke, J. P. Tuckermann, M. Tjwa, P. Carmeliet, V. Mandic, J. P. David, A. Behrens, A. Nagy, G. Carmeliet & J. J. Haigh. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J 29: 424-41 (2010) (IF = 10.1 ; C = 167) PubMed

N. Azoitei, G.V. Pusapati, A. Kleger, P. Moller, R. Kufer, F. Genze, M. Wagner, J. van Lint, P. Carmeliet, G. Adler & T. Seufferlein. Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Gut 59: 1316-30 (2010) (IF = 9.3 ; C = 66) PubMed

C. Ruiz de Almodovar, C. Coulon, P. A. Salin, E. Knevels, N. Chounlamountri, K. Poesen, K. Hermans, D. Lambrechts, K. Van Geyte, J. Dhondt, T. Dresselaers, J. Renaud, J. Aragones, S. Zacchigna, I. Geudens, D. Gall, S. Stroobants, M. Mutin, K. Dassonville, E. Storkebaum, B. F. Jordan, U. Eriksson, L. Moons, R. D'Hooge, J. J. Haigh, M. F. Belin, S. Schiffmann, P. Van Hecke, B. Gallez, S. Vinckier, A. Chedotal, J. Honnorat, N. Thomasset, P. Carmeliet & C. Meissirel. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci 30: 15052-66 (2010) (IF = 7.8 ; C = 72) PubMed

L. Coenegrachts, C. Maes, S. Torrekens, R. Van Looveren, M. Mazzone, T.A. Guise, R. Bouillon, J.M. Stassen, P. Carmeliet & G. Carmeliet. Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation. Cancer Res 70: 6537-47 (2010) (IF = 7.5 ; C = 45) PubMed

C. Coulon, M. Georgiadou, C. Roncal, K. De Bock, T. Langenberg & P. Carmeliet. From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery. Arterioscler Thromb Vasc Biol 30: 2331-6 (2010) (IF = 7.2 ; C = 51) PubMed

I. Geudens, R. Herpers, K. Hermans, I. Segura, C. Ruiz de Almodovar, J. Bussmann, F. De Smet, W. Vandevelde, B.M. Hogan, A. Siekmann, F. Claes, J.C. Moore, A.S. Pistocchi, S. Loges, M. Mazzone, G. Mariggi, F. Bruyere, F. Cotelli, D. Kerjaschki, A. Noel, J.M. Foidart, H. Gerhardt, A. Ny, T. Langenberg, N.D. Lawson, H.J. Duckers, S. Schulte-Merker, P. Carmeliet & M. Dewerchin. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol 30: 1695-702 (2010) (IF = 7.2 ; C = 105) PubMed

B. Costa, D. Dettori, A. Lorenzato, C. Bardella, N. Coltella, C. Martino, C. Cammarata, P. Carmeliet, M. Olivero & M.F. Di Renzo. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J 24: 2680-8 (2010) (IF = 7.0 ; C = 10) PubMed

A. Vanden Bosch, T. Raemaekers, S. Denayer, S. Torrekens, N. Smets, K. Moermans, M. Dewerchin, P. Carmeliet & G. Carmeliet. NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. J Cell Sci 123: 3244-55 (2010) (IF = 6.1 ; C = 51) PubMed

J. Le Dall, B. Ho-Tin-Noe, L. Louedec, O. Meilhac, C. Roncal, P. Carmeliet, S. Germain, J. B. Michel & X. Houard. Immaturity of microvessels in haemorrhagic plaques is associated with proteolytic degradation of angiogenic factors. Cardiovasc Res 85: 184-93 (2010) (IF = 6.0 ; C = 33) PubMed

C. Roncal, I. Buysschaert, N. Gerdes, M. Georgiadou, O. Ovchinnikova, C. Fischer, J.M. Stassen, L. Moons, D. Collen, K. De Bock, G.K. Hansson & P. Carmeliet. Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Cardiovasc Res 86: 29-36 (2010) (IF = 6.0 ; C = 46) PubMed

J.M. Cosemans, R. van Kruchten, S. Olieslagers, L.J. Schurgers, F.K. Verheyen, I.C. Munnix, J. Waltenberger, A. Angelillo-Scherrer, M.F. Hoylaerts, P. Carmeliet & J.W. Heemskerk. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost 8: 1797-808 (2010) (IF = 6.0 ; C = 95) PubMed

L. Fabritz, D. Damke, M. Emmerich, S. Kaufmann, K. Theis, A. Blana, L. Fortmuller, S. Laakmann, S. Hermann, E. Aleynichenko, J. Steinfurt, D. Volkery, B. Riemann, U. Kirchhefer, M.R. Franz, G. Breithardt, E. Carmeliet, M. Schafers, S.K. Maier, P. Carmeliet & P. Kirchhof. Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovasc Res 87: 60-72 (2010) (IF = 5.9 ; C = 47) PubMed

P. Hindryckx, A. Waeytens, D. Laukens, H. Peeters, J. Van Huysse, L. Ferdinande, P. Carmeliet & M. De Vos. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury. Lab Invest 90: 566-76 (2010) (IF = 4.6 ; C = 38) PubMed

A. Blana, S. Kaese, L. Fortmuller, S. Laakmann, D. Damke, K.V. Bragt, J. Eckstein, I. Piccini, U. Kirchhefer, S. Nattel, G. Breithardt, P. Carmeliet, E. Carmeliet, U. Schotten, S. Verheule, P. Kirchhof & L. Fabritz. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm 7: 1862-9 (2010) (IF = 4.5 ; C = 49) PubMed

C.E. Pierreux, S. Cordi, A.C. Hick, Y. Achouri, C. Ruiz de Almodovar, P.P. Prevot, P.J. Courtoy, P. Carmeliet & F.P. Lemaigre. Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. Dev Biol 347: 216-27 (2010) (IF = 4.4 ; C = 63) PubMed

A. Quaegebeur & P. Carmeliet. Oxygen sensing: a common crossroad in cancer and neurodegeneration. Curr Top Microbiol Immunol 345: 71-103 (2010) (Review) (IF = 4.1 ; C = 22) PubMed

A. Brockington, P. R. Heath, H. Holden, P. Kasher, F. L. Bender, F. Claes, D. Lambrechts, M. Sendtner, P. Carmeliet & P. J. Shaw. Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF delta/delta mouse model of amyotrophic lateral sclerosis. BMC Genomics 11: 203 (2010) (IF = 3.9 ; C = 35) PubMed

A. Debeer, L. Sbragia, K. Vrancken, A. Hendriks, X. Roubliova, J. Jani, G. Naulaers, P. Carmeliet & J. Deprest. Antenatal fetal VEGF therapy to promote pulmonary maturation in a preterm rabbit model. Early Hum Dev 86: 99-105 (2010) (IF = 2.1 ; C = 17) PubMed

S. Loges, T. Schmidt & P. Carmeliet. Mechanisms of Resistance to Anti- Angiogenic Therapy and Development of Third-Generation Anti-Angiogenic Drug Candidates. Genes & Cancer 1: 12–25 (2010) (Review) (IF = N/A ; C = 0) PubMed

M. Mazzone, D Dettori, R. Leite de Oliveira, S. Loges, Th. Schmidt, B. Jonckx, Y. Tian, A. A. Lanahan, P. Pollard, C. Ruiz de Almodovar, F. De Smet, S. Vinckier, J. Aragones, A. Luttun, S. Wyns, B. Jordan, A. Pisacane, B. Gallez, M. G. Lampugnani, E. Dejana, M. Simons, P. Ratcliffe, P. Maxwell & P. Carmeliet. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136: 839-51 (2009) (IF = 29.9 ; C = 691) (highlighted by (inter)-national press). PubMed

C. Ruiz de Almodovar, D. Lambrechts, M. Mazzone & P. Carmeliet. Role and therapeutic potential of VEGF in the nervous system. Physiol Rev 89: 607-48 (2009) (Review) (IF = 26.9 ; C = 358).PubMed

S. Loges, M. Mazzone, Ph. Hohensinner & P. Carmeliet. Silencing or fueling metastasis with VEGF inhibitors: anti-angiogenesis revisited. Cancer Cell 3: 167-70 (2009) (Invited Review) (IF = 23.8 ; C = 365) PubMed

P. Fraisl, J. Aragonés & P. Carmeliet. Inhibition of oxygen sensors as therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Disc 8: 139-52 (2009) (Review) (IF = 23.3 ; C = 295) PubMed

J. Aragones, P. Fraisl, M. Baes & P. Carmeliet. Oxygen sensors at the crossroad of metabolism. Cell Metab 9: 11-22 (2009) (IF = 17.1 ; C = 253) PubMed

M. Tjwa, N. Sidenius, R. Moura, S. Jansen, K. Theunissen, L. Moons, A. Andolfo, M. De Mol, M. Dewerchin, L. Moons, F. Blasi, C. Verfaillie & P. Carmeliet. Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment and mobilization of hematopoietic stem/progenitor cells. J. Clin Invest 119: 1008-18 (2009) (IF = 16.9 ; C = 58) PubMed

M. W. Schellings, D. Vanhoutte, M. Swinnen, J. P. Cleutjens, J. Debets, R. E. van Leeuwen, J. d'Hooge, F. Van de Werf, P. Carmeliet, Y. M. Pinto, E. H. Sage & S. Heymans. Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J Exp Med 206: 113-23 (2009) (IF = 15.6 ; C = 179) PubMed

J. E. Lähteenvuo, M. T. Lahteenvuo, A. Kivela, C. Rosenlew, A. Falkevall, J. Klar, T. Heikura, T. T. Rissanen, E. Vahakangas, P. Korpisalo, B. Enholm, P. Carmeliet, K. Alitalo, U. Eriksson & S. Yla-Herttuala. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms. Circulation 119: 845-56 (2009) (IF = 12.8 ;  C = 164) PubMed

M. Swinnen, D. Vanhoutte, G.C. Van Almen, N. Hamdani, M.W. Schellings, J. D'Hooge, J. Van der Velden, M.S. Weaver, E.H. Sage, P. Bornstein, F.K. Verheyen, T. VandenDriessche, M.K. Chuah, D. Westermann, W.J. Paulus, F. Van de Werf, B. Schroen, P. Carmeliet, Y.M. Pinto & S. Heymans. Absence of thrombospondin-2 causes age-related dilated cardiomyopathy. Circulation 120: 1585-97 (2009) (IF = 12.8 ; C = 86) PubMed

P. Fraisl, M. Mazzone, T. Schmidt & P. Carmeliet. Regulation of angiogenesis by oxygen and metabolism. Dev Cell 16: 167-79 (2009) (Invited Review) (IF = 12.4 ; C = 375) PubMed

C. Van Steenkiste, A. Geerts, E. Vanheule, H. Van Vlierberghe, F. De Vos, K. Olievier, C. Casteleyn, D. Laukens, M. De Vos, J. M. Stassen, P. Carmeliet & I. Colle. Role of Placental Growth Factor in Mesenteric Neo-Angiogenesis in a Mouse Model of Portal Hypertension. Gastroenterology 137: 2112-24 (2009) (IF = 11.7 ; C = 47) PubMed

M. Tjwa, L. Moons, C. Verfaillie & P. Carmeliet. Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. Blood 113: 1608-9 (2009) (IF = 10.9).

P. Carmeliet, F. De Smet, S. Loges & M. Mazzone. Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol 6: 315-26 (2009) (Review) (IF = 10.8 ; C = 214) PubMed

C. D'Aniello, E. Lonardo, S. Iaconis, O. Guardiola, A. M. Liguoro, G. L. Liguori, M. Autiero, P. Carmeliet & G. Minchiotti. G Protein-Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway. Circ Res 105: 231-8 (2009) (IF = 9.9 ; C = 82) PubMed

I. Segura, F. De Smet, P. J. Hohensinner, C. R. Almodovar & P. Carmeliet. The neurovascular link in health and disease: an update. Trends Mol Med 15: 439-51 (2009) (Review) (IF = 9.6 ; C = 68) PubMed

C. L. Simpson, R. Lemmens, K. Miskiewicz, W. J. Broom, V. K. Hansen, P. W. van Vught, J. E. Landers, P. Sapp, L. Van Den Bosch, J. Knight, B. M. Neale, M. R. Turner, J. H. Veldink, R. A. Ophoff, V. B. Tripathi, A. Beleza, M. N. Shah, P. Proitsi, A. Van Hoecke, P. Carmeliet, H. R. Horvitz, P. N. Leigh, C. E. Shaw, L. H. van den Berg, P. C. Sham, J. F. Powell, P. Verstreken, R. H. Brown, Jr. W. Robberecht & A. Al-Chalabi. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet 18: 472-81 (2009) (IF = 7.8 ; C = 253) PubMed

S. Zacchigna, H. Oh, M. Wilsch-Bräuninger, E. Missol-Kolka, J. Jaszai, S. Jansen, N. Tanimoto, F. Tonagel, M. Seeliger, W. B. Huttner, D. Corbeil, M. Dewerchin, S. Vinckier, L. Moons & P. Carmeliet. Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J.Neurosc 29: 2297-308 (2009) (IF = 7.5 ; C = 156) PubMed

J. K. Park, S. Theuer, T. Kirsch, C. Lindschau, U. Klinge, A. Heuser, R. Plehm, M. Todiras, P. Carmeliet, H. Haller, F. C. Luft, D. N. Muller & A. Fiebeler. Growth Arrest Specific Protein 6 Participates in DOCA-Induced Target-Organ Damage. Hypertension 54: 359-64 (2009) (IF = 7.4 ; C = 14) PubMed

F. De Smet, I. Segura, K. De Bock, P. J. Hohensinner & P. Carmeliet. Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way. Arterioscler Thromb Vasc Biol 29: 639-49 (2009) (Review) (IF = 7.2 ; C = 331) PubMed

S. Loges, T. Schmidt & P. Carmeliet. "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF. Clin Cancer Res 15: 3648-53 (2009) (Review) (IF = 6.5 ; C = 59) PubMed

S. Loges, C. Roncal & P. Carmeliet. Development of targeted angiogenic medicine. J Thromb Haemost 7: 21-33 (2009) (Review) (IF = 5.9 C = 61) PubMed

B. S. Pedroja, L. E. Kang, A. O. Imas, P. Carmeliet & A. M. Bernstein. Plasminogen Activator Inhibitor-1 Regulates Integrin alphavbeta3 Expression and Autocrine TGFbeta Signaling. J Biol Chem 284: 20708-17 (2009) (IF = 5.5 ; C = 31) PubMed

M. Tjwa, R. Moura, L. Moons, S. Plaisance, M. De Mol, S. Jansen, M. Dewerchin, C. Verfaillie & P. Carmeliet. Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation. J Cell Mol Med 13: 4587-95 (2009) (IF = 5.2 ; C = 19) PubMed

M. Koch, D. Dettori, A. Van Nuffelen, J. Souffreau, L. Marconcini, G. Wallays, L. Moons, F. Bruyere, S. Oliviero, A. Noel, J. M. Foidart. P. Carmeliet & M. Dewerchin. VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis. J Pathol 219: 356-64 (2009) (IF = 5.1 ; C = 38) PubMed

K. De Bock, F. De Smet, R. Leite De Oliveira, K. Anthonis & P. Carmeliet. Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells. J Mol Med 87: 561-9 (2009) (Review) (IF = 4.4 ; C = 34) PubMed

A. Tintu, E. Rouwet, S. Verlohren, J. Brinkmann, S. Ahmad, F. Crispi, M. van Bilsen, P. Carmeliet, A. C. Staff, M. Tjwa, I. Cetin, E. Gratacos, E. Hernandez-Andrade, L. Hofstra, M. Jacobs, W. H. Lamers, I. Morano, E. Safak, A. Ahmed & F. le Noble. Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences. PLoS ONE 4: e5155 (2009) (IF = 4.3. ; C = 107) PubMed

A. Van den Bergh, P. Vangheluwe, A. Vanderper, P. Carmeliet, F. Wuytack, S. Janssens, W. Flameng, P. Holvoet & P. Herijgers. Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve. Eur J Heart Fail 11: 1118-25 (2009) (IF = 3.4 ; C  = 12) PubMed

D. Lambrechts, K. Poesen, R. Fernandez-Santiago, A. Al-Chalabi, R. Del Bo, P.W. Van Vught, S. Khan, S.L. Marklund, A. Brockington, I. van Marion, J. Anneser, C. Shaw, A.C. Ludolph, N.P. Leigh, G.P. Comi, T. Gasser, P.J. Shaw, K.E. Morrison, P.M. Andersen, L.H. Van den Berg, V. Thijs, T. Siddique, W. Robberecht & P. Carmeliet. Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype. J Med Genet 46: 840-6 (2009) (IF = 3.4 ; C. = 75) PubMed

S. L. Cheng, H. C. Wang, C. J. Yu, P. N. Tsao, P. CARMELIET, S. J. Cheng & P. C. Yang. Prevention of elastase-induced emphysema in placenta growth factor knock-out mice. Respir Res 10: 115 (2009) (IF = 3.4 ; C = 27) PubMed

S. Vanhaesebrouck, H. Daniels, L. Moons, C. Vanhole, P. Carmeliet & F. De Zegher. Oxygen-induced retinopathy in mice: amplification by neonatal IGF-I deficit and attenuation by IGF-I administration. Pediatr Res 65: 307-10 (2009) (IF = 2.8 ; C = 75) PubMed

P. Carmeliet & M. Baes. Metabolism and therapeutic angiogenesis. N Engl J Med 358: 2511-2 (2008) (IF = 52.6 ; C = 39) PubMed

C. Fischer, M. Mazzone, B. Jonckx & P. Carmeliet. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nat Rev Cancer 8: 942-56 (2008) (Review) (IF = 29.2 ; C = 508) PubMed

M. Mazzone & P. Carmeliet. Drug discovery: a lifeline for suffocating tissues. Nature 453: 1194-5 (2008) (News and Views) (IF = 28.7 ;C = 23) PubMed

C. Wei, C. C. Moller, M. M. Altintas, J. Li, K. Schwarz, S. Zacchigna, L. Xie, A. Henger, H. Schmid, M. P. Rastaldi, P. Cowan, M. Kretzler, R. Parrilla, M. Bendayan, V. Gupta, B. Nikolic, R. Kalluri, P. Carmeliet, P. Mundel & J. Reiser. Modification of kidney barrier function by the urokinase receptor. Nat Med 14: 55-63 (2008) (IF = 26.4 ; C = 484) PubMed

J. Aragones, M. Schneider, K. Van Geyte, P. Fraisl, T. Dresselaers, M. Mazzone, R. Dirkx, S. Zacchigna, H. Lemieux, N. H. Jeoung, D. Lambrechts, T. Bishop, P. Lafuste, A. Diez-Juan, S. K. Harten, P. Van Noten, K. De Bock, C. Willam, M. Tjwa, A. Grosfeld, R. Navet, L. Moons, T. Vandendriessche, C. Deroose, B. Wijeyekoon, J. Nuyts, B. Jordan, R. Silasi-Mansat, F. Lupu, M. Dewerchin, C. Pugh, P. Salmon, L. Mortelmans, B. Gallez, F. Gorus, J. Buyse, F. Sluse, R. A. Harris, E. Gnaiger, P. Hespel, P. Van Hecke, F. Schuit, P. Van Veldhoven, P. Ratcliffe, M. Baes, P. Maxwell & P. Carmeliet. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40: 170-80 (2008) (IF = 25.5 ; C = 420) PubMed

S. Zacchigna, D. Lambrechts & P. Carmeliet. Neurovascular signalling defects in neuro-degeneration. Nat Rev Neurosci 9: 169-81 (2008) (Review) (IF = 24.5 ; C = 303) PubMed

A. Angelillo-Scherrer, L. Burnier, D. Lambrechts, R. J. Fish, M. Tjwa, S. Plaisance, R. Sugamele, M. DeMol, E. Martinez-Soria, P. H. Maxwell, G. Lemke, S. P. Goff, G. K. Matsushima, H. S. Earp, M. Chanson, D. Collen, S. Izui, M. Schapira, E. M. Conway & P. Carmeliet. Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest 118: 583-96 (2008) (IF = 16.9 ; C. =107) PubMed

M. Murakami, L. T. Nguyen, Z. W. Zhang, K. L. Moodie, P. Carmeliet, R. V. Stan & M. Simons. The FGF system has a key role in regulating vascular integrity. J Clin Invest 118: 3355-66 (2008) (IF = 16.9 ; C = 271) PubMed

J. Fu, H. Gerhardt, J. M. McDaniel, B. Xia, X. Liu, L. Ivanciu, A. Ny, K. Hermans, R. Silasi-Mansat, S. McGee, E. Nye, T. Ju, M. I. Ramirez, P. Carmeliet, R. D. Cummings, F. Lupu & L. Xia. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 118: 3725-37 (2008) (IF = 16.9 ; C = 207) PubMed

C. Rolny, L. Capparuccia, A. Casazza, M. Mazzone, A. Vallario, A. Cignetti, E. Medico, P. Carmeliet, P. M. Comoglio & L. Tamagnone. The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. J Exp Med 205: 1155-71 (2008) (IF = 15.6 ; C = 86) PubMed

K. Yano, Y. Okada, G. Beldi, S. C. Shih, N. Bodyak, H. Okada, P. M. Kang, W. Luscinskas, S. C. Robson, P. Carmeliet, S. A. Karumanchi & W. C. Aird. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med 205: 2623-31 (2008) (IF = 15.6 ; C = 38) PubMed

F. Bruyere, L. Melen-Lamalle, S. Blacher, G. Roland, M. Thiry, L. Moons, F. Frankenne, P. Carmeliet, K. Alitalo, C. Libert, J. P. Sleeman, J. M. Foidart & A. Noel. Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods 5: 431-7 (2008) (IF = 15.5 ; C = 106) PubMed

B. Vidal, A. L. Serrano, M. Tjwa, M. Suelves, E. Ardite, R. De Mori, B. Baeza-Raja, M. Martinez de Lagran, P. Lafuste, V. Ruiz-Bonilla, M. Jardi, R. Gherardi, C. Christov, M. Dierssen, P. Carmeliet, J. L. Degen, M. Dewerchin & P. Munoz-Canoves. Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev 22: 1747-52 (2008) (IF = 14.8 ; C = 220) PubMed

P. Fraisl, M. Baes & P. Carmeliet. Hungry for blood vessels: linking metabolism and angiogenesis. Dev Cell 14: 313-4 (2008) (Preview) (IF = 12.4 ; C = 15) PubMed

A. Ny, M. Koch, W. Vandevelde, M. Schneider, C. Fischer, A. Diez-Juan, E. Neven, I. Geudens, S. Maity, L. Moons, S. Plaisance, D. Lambrechts, P. Carmeliet & M. Dewerchin. Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles. Blood 112: 1740-9 (2008) (IF = 10.9 ; C = 43) PubMed

M. Tjwa, L. Bellido-Martin, Y. Lin, E. Lutgens, S. Plaisance, F. Bono, N. Delesque-Touchard, C. Herve, R. Moura, A. D. Billiau, C. Aparicio, M. Levi, M. Daemen, M. Dewerchin, F. Lupu, J. Arnout, J. M. Herbert, M. Waer, P. Garcia de Frutos, B. Dahlback, P. Carmeliet, M. F. Hoylaerts & L. Moons. Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood 111: 4096-105 (2008) (IF = 10.9 ; C = 142) PubMed

M. Tjwa, S. Janssens & P. Carmeliet. Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 112: 4048-50 (2008) (IF = 10.9 ; C = 30) PubMed

P. Van Damme, A. Van Hoecke, D. Lambrechts, P. Vanacker, E. Bogaert, J. van Swieten, P. Carmeliet, L. Van Den Bosch & W. Robberecht. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol 181: 37-41 (2008) (IF = 9.6 ; C  = 378) PubMed

M. D. Binder, H. S. Cate, A. L. Prieto, D. Kemper, H. Butzkueven, M. M. Gresle, T. Cipriani, V. G. Jokubaitis, P. Carmeliet & T. J. Kilpatrick. Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. J Neurosci 28: 5195-206 (2008) (IF = 7.5 ; C = 111) PubMed

K. Poesen, D. Lambrechts, P. Van Damme, J. Dhondt, F. Bender, N. Frank, E. Bogaert, B. Claes, L. Heylen, A. Verheyen, K. Raes, M. Tjwa, U. Eriksson, M. Shibuya, R. Nuydens, L. Van Den Bosch, T. Meert, R. D'Hooge, M. Sendtner, W. Robberecht & P. Carmeliet. Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration. J Neurosci 28: 10451-9 (2008) (IF = 7.5 ; C = 124) PubMed

X. Li, M. Tjwa, I. Van Hove, B. Enholm, E. Neven, K. Paavonen, M. Jeltsch, T. D. Juan, R. E. Sievers, E. Chorianopoulos, H. Wada, M. Vanwildemeersch, A. Noel, J. M. Foidart, M. L. Springer, G. von Degenfeld, M. Dewerchin, H. M. Blau, K. Alitalo, U. Eriksson, P. Carmeliet & L. Moons. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol 28: 1614-20 (2008) (IF = 7.2 ; C = 102) PubMed

P. Hill, D. Shukla, M. G. Tran, J. Aragones, H. T. Cook, P. Carmeliet & P. H. Maxwell. Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 19: 39-46 (2008) (IF = 7.1 ; C = 251) PubMed

I. Buysschaert, T. Schmidt, C. Roncal, P. Carmeliet & D. Lambrechts. Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis. J Cell Mol Med 12: 2533-51 (2008) (Review) (IF =  6.8 ; C = 57) PubMed

T. Bishop, D. Gallagher, A. Pascual, C. A. Lygate, J. P. de Bono, L. G. Nicholls, P. Ortega-Saenz, H. Oster, B. Wijeyekoon, A. I. Sutherland, A. Grosfeld, J. Aragones, M. Schneider, K. van Geyte, D. Teixeira, A. Diez-Juan, J. Lopez-Barneo, K. M. Channon, P. H. Maxwell, C. W. Pugh, A. M. Davies, P. Carmeliet & P. J. Ratcliffe. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol 28: 3386-400 (2008) (IF = 6.4 ; C = 186) PubMed

O. Mikhaylova, M. L. Ignacak, T. J. Barankiewicz, S. V. Harbaugh, Y. Yi, P. H. Maxwell, M. Schneider, K. Van Geyte, P. Carmeliet, M. P. Revelo, M. Wyder, K. D. Greis, J. Meller & M. F. Czyzyk-Krzeska. The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Mol Cell Biol 28: 2701-17 (2008) (IF = 6.4 ; C = 109) PubMed

N. M. van den Akker, V. Caolo, L. J. Wisse, P. P. Peters, R. E. Poelmann, P. Carmeliet, D. G. Molin & A. C. Gittenberger-de Groot. Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signaling. Cardiovasc Res 78: 366-75 (2008) (IF = 6.1 ; C = 35) PubMed

R. Renckens, J. J. Roelofs, M. E. Stegenga, S. Florquin, M. Levi, P. Carmeliet, C. Van't Veer & T. van der Poll. Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia. J Thromb Haemost 6: 660-8 (2008) (IF = 5.9 ; C = 16) PubMed

E. Lutgens, M. Tjwa, P. Garcia de Frutos, E. Wijnands, L. Beckers, B. Dahlback, M. J. Daemen, P. Carmeliet & L. Moons. Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 216: 55-63 (2008) (IF = 5.4 ; C = 61) PubMed

C. Roncal, I. Buysschaert, E. Chorianopoulos, M. Georgiadou, O. Meilhac, M. Demol, J. B. Michel, S. Vinckier, L. Moons & P. Carmeliet. Beneficial effects of prolonged systemic administration of PlGF on late outcome of post-ischaemic myocardial performance. J Pathol 216: 236-44 (2008) (IF = 5.4 ; C. =37) PubMed

L. Li, A. Lundkvist, D. Andersson, U. Wilhelmsson, N. Nagai, A. C. Pardo, C. Nodin, A. Stahlberg, K. Aprico, K. Larsson, T. Yabe, L. Moons, A. Fotheringham, I. Davies, P. Carmeliet, J. P. Schwartz, M. Pekna, M. Kubista, F. Blomstrand, N. Maragakis, M. Nilsson & M. Pekny. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 28: 468-81 (2008) (IF = 5.1 ; C = 461) PubMed

P. Wolter, C. Stefan, B. Decallonne, H. Dumez, M. Bex, P. Carmeliet & P. Schoffski. The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation. Br J Cancer 99: 448-54 (2008) (IF = 4.6 ; C = 156) PubMed

S. Zacchigna, C. Ruiz de Almodovar & P. Carmeliet. Similarities between angiogenesis and neural development: what small animal models can tell us. Curr Top Dev Biol 80: 1-55 (2008) (Review) (IF = 4.6 ; C =62) PubMed

M. Freitas-Andrade, P. Carmeliet, D. B. Stanimirovic & M. Moreno. VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes. J Neurochem 107: 756-67 (2008) (IF = 4.5 ; C = 30) PubMed

P. CARMELIET. Neuro-vascular link: from genetic insights to therapeutic perspectives. Bull Mem Acad R Med Belg 163: 445-51; discussion 451-442 (2008) (IF = N/A ; C = 8) PubMed

C. Fischer, B. Jonckx, M. Mazzone, S. Zacchigna, S. Loges, L. Pattarini, E. Chorianopoulos, L. Liesenborghs, M. Koch, M. De Mol, M. Autiero, S. Wyns, Z. Plaisance, L. Moons, N. van Rooijen, M. Giacca, J.M. Stassen, M. Dewerchin, D. Collen & P. Carmeliet. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131: 463-75 (2007) (IF = 29.0 ; C = 730) (highlighted by (inter)-national press). PubMed

M. Mazzone, C. Ruiz de Almodovar & P. Carmeliet. Building in resistance to endothelial cell death. Nat Genet 39: 1308-9 (2007) (Comment) (IF = 24.2 ; C = 2) PubMed

D. Tirziu, E. Chorianopoulos, K. L. Moodie, R. T. Palac, Z. W. Zhuang, M. Tjwa, C. Roncal, U. Eriksson, Q. Fu, A. Elfenbein, A. E. Hall, P. Carmeliet, L. Moons & M. Simons. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 117: 3188-97 (2007) (IF = 15.7 ; C = 127) PubMed

B. Larrivee, C. Freitas, M. Trombe, X. Lv, B. Delafarge, L. Yuan, K. Bouvree, C. Breant, R. Del Toro, N. Brechot, S. Germain, F. Bono, F. Dol, F. Claes, C. Fischer, M. Autiero, J. L. Thomas & P. Carmeliet, M. Tessier-Lavigne & A. Eichmann. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev 21: 2433-47 (2007) (IF = 15.1 ; C = 196) PubMed

D. Lambrechts, W. Robberecht & P. Carmeliet. Heterogeneity in motoneuron disease. Trends Neurosci 30: 536-44 (2007) (Review) (IF = 13.5 ; C = 22) PubMed

D. Vanhoutte, M. W. Schellings, M. Gotte, M. Swinnen, V. Herias, M. K. Wild, D. Vestweber, E. Chorianopoulos, V. Cortes, A. Rigotti, M. A. Stepp, F. Van de Werf, P. Carmeliet, Y. M. Pinto & S. Heymans. Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction. Circulation 115: 475-82 (2007) (IF = 11.6 ; C = 124) PubMed

S. Tugues, G. Fernandez-Varo, J. Munoz-Luque, J. Ros, V. Arroyo, J. Rodes, S. L. Friedman, P. Carmeliet, W. Jimenez & M. Morales-Ruiz. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 46: 1919-26 (2007) (IF = 10.4 ; C = 239) PubMed

M. Suelves, B. Vidal, A. L. Serrano, M. Tjwa, J. Roma, R. Lopez-Alemany, A. Luttun, M. M. de Lagran, A. Diaz-Ramos, M. Jardi, M. Roig, M. Dierssen, M. Dewerchin, P. Carmeliet & P. Munoz-Canoves. uPA deficiency exacerbates muscular dystrophy in MDX mice. J Cell Biol 178: 1039-51 (2007) (IF = 10.1 ; C. = 68) PubMed

R. Renckens, J. J. Roelofs, P. I. Bonta, S. Florquin, C. J. de Vries, M. Levi, P. Carmeliet, C. van't Veer & T. van der Poll. Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. Blood 109: 1593-601 (2007) (IF = 10.1 ; C. =92) PubMed

N. M. van den Akker, D. G. Molin, P. P. Peters, S. Maas, L. J. Wisse, R. van Brempt, C. J. van Munsteren, M. M. Bartelings, R. E. Poelmann, P. Carmeliet & A. C. Gittenberger-de Groot. Tetralogy of Fallot and Alterations in Vascular Endothelial Growth Factor-A Signaling and Notch Signaling in Mouse Embryos Solely Expressing the VEGF120 Isoform. Circ Res 100: 842-9 (2007) (IF = 9.4 ; C = 54) PubMed

P. Van Damme, E. Bogaert, M. Dewil, N. Hersmus, D. Kiraly, W. Scheveneels, I. Bockx, D. Braeken, N. Verpoorten, K. Verhoeven, V. Timmerman, P. Herijgers, G. Callewaert, P. Carmeliet, L. Van Den Bosch & W. Robberecht. Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc Natl Acad Sci U S A 104: 14825-30 (2007) (IF = 9.4 ; C = 194) PubMed

R. Lemmens, A. Van Hoecke, N. Hersmus, V. Geelen, I. D'hollander, V. Thijs, L. Van Den Bosch, P. Carmeliet & W. Robberecht. Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. Hum Mol Genet 16: 2359-65 (2007) (IF = 8.1 ; C = 138) PubMed

C. V. Esguerra, L. Nelles, L. Vermeire, A. Ibrahimi, A. D. Crawford, R. Derua, E. Janssens, E. Waelkens, P. Carmeliet, D. Collen & D. Huylebroeck. Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development 134: 4381-93 (2007) (IF = 7.7 ; C = 44) PubMed

P. Giacobini, A. Messina, S. Wray, C. Giampietro, T. Crepaldi, P. Carmeliet & A. Fasolo. Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. J Neurosci 27: 431-45 (2007) (IF = 7.5 ; C = 76) PubMed

C. Tayade, D. Hilchie, H. He, Y. Fang, L. Moons, P. Carmeliet, R. A. Foster & B. A. Croy. Genetic deletion of placenta growth factor in mice alters uterine NK cells. J Immunol 178: 4267-75 (2007) (IF = 6.3 ; C = 98) PubMed

K. H. Sonoda, T. Nakamura, H. A. Young, D. Hart, P. Carmeliet & J. Stein-Streilein. NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye. J Immunol 179: 2215-22 (2007) (IF = 6.3 ; C = 19) PubMed

M. Jost, C. Maillard, J. Lecomte, V. Lambert, M. Tjwa, P. Blaise, M. L. Alvarez Gonzalez, K. Bajou, S. Blacher, P. Motte, C. Humblet, M. P. Defresne, M. Thiry, F. Frankenne, A. Gothot, P. Carmeliet, J. M. Rakic, J. M. Foidart & A. Noel. Tumoral and Choroidal Vascularization. Differential Cellular Mechanisms Involving Plasminogen Activator Inhibitor Type I. Am J Pathol 171: 1369-80 (2007) (IF = 5.9 ; C = 15) PubMed

M. Lassila, K. Fukami, K. Jandeleit-Dahm, T. Semple, P. Carmeliet, M. E. Cooper & A. R. Kitching. Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease. Diabetologia 50: 1315-26 (2007) (IF = 5.2 ; C = 42) PubMed

M. Cacquevel, S. Launay, H. Castel, K. Benchenane, S. Cheenne, L. Buee, L. Moons, A. Delacourte, P. Carmeliet & D. Vivien. Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms. Neurobiol Dis 27: 164-73 (2007) (IF = 4.3 ; C. =60) PubMed

V. Laudenbach, R. H. Fontaine, F. Medja, P. Carmeliet, D. J. Hicklin, J. Gallego, P. Leroux, S. Marret & P. Gressens. Neonatal hypoxic preconditioning involves vascular endothelial growth factor. Neurobiol Dis 26: 243-52 (2007) (IF = 4.3 ; C = 45) PubMed

P. Leroux, O. Hennebert, H. Legros, V. Laudenbach, P. Carmeliet & S. Marret. Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: Interaction with plasmin inhibitors and anti-inflammatory drugs. Neuroscience 146: 670-8 (2007) (IF = 3.4 ; C = 8) PubMed

I. Buysschaert, P. Carmeliet & M. Dewerchin. Clinical and fundamental aspects of angiogenesis and anti-angiogenesis. Acta Clin Belg 62: 162-9 (2007) (Review) (IF = 0.6 ; C = 15) PubMed

C. Ruiz de Almodovar, A. Luttun & P. Carmeliet. An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 124: 18-21 (2006) (Review) (IF = 29.4 ; C = 53) PubMed

C. Fischer, P. Carmeliet & E. M. Conway. VEGF inhibitors make blood. Nat Med 12: 732-4 (2006) (News and Views) (IF = 28.8 ; C = 17) PubMed

S. Aerts, D. Lambrechts, S. Maity, P. Van Loo, B. Coessens, F. De Smet, L.C. Tranchevent, B. De Moor, P. Marynen, B. Hassan, P. Carmeliet & Y. Moreau. Gene priorization through genomic data fusion. Nat Biotechnol 24: 537-44 (2006) (IF = 22.7 ; C = 741) PubMed

B. Le Bras, M. Barallobre, J. Homman-Ludiye, A. Ny, S. Wyns, T. Tammela, P. Haiko, M. J. Karkkainen, L. Yuan, M. Muriel, E. Chatzopoulou, C. Bréant, B. Zalc, P. Carmeliet, K. Alitalo, A. Eichmann & J.-L. Thomas. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.Nat Neurosci 9: 340-8 (2006) (IF = 15.4 ; C = 164) PubMed

C. Maes, L. Coenegrachts, I. Stockmans, E. Daci, A. Luttun, A. Petryk, R. Goapalkrishnan, K. Moermans, N. Smets, C. M. Verfaillie, P. Carmeliet, R. Bouillon & G. Carmeliet. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin Invest 116: 1230-1242 (2006) (IF = 15.0 ; C = 146) PubMed

R. Masuyama, I. Stockmans, S. Torrekens, R. Van Looveren, C. Maes, P. Carmeliet, R. Bouillon & G. Carmeliet. Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116: 3150-9 (2006) (IF = 15.0 ; C = 258) PubMed

Y. He, Y. Luo, S. Tang, I. Rajantie, P. Salven, M. Heil, R. Zhang, D. Luo, X. Li, H. Chi, J. Yu, P. Carmeliet, W. Schaper, A. J. Sinusas, W. C. Sessa, K. Alitalo & W. Min. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest 116: 2344-55 (2006) (IF = 15.0 ; C = 78) PubMed

T. W. Chittenden, F. Claes, A. A. Lanahan, M. Autiero, R. T. Palac, E. V. Tkachenko, A. Elfenbein, C. Ruiz de Almodovar, E. Dedkov, R. Tomanek, W. Li, M. Westmore, J. P. Singh, A. Horowitz, M. J. Mulligan-Kehoe, K. L. Moodie, Z. W. Zhuang, P. Carmeliet & M. Simons. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell 10: 783-95 (2006) (IF = 14.6 ; C = 124) PubMed

K. Yano, P. C. Liaw, J. M. Mullington, S. C. Shih, H. Okada, N. Bodyak, P. M. Kang, L. Toltl, B. Belikoff, J. Buras, B. T. Simms, J. P. Mizgerd, P. Carmeliet, S. A. Karumanchi & W. C. Aird. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 203: 1447-58 (2006) (IF = 13.9 ; C = 251) PubMed

M. Schneider, A. Ny, C. R. de Almodovar & P. Carmeliet. A new mouse model to study acquired lymphedema. PLoS Med 3(7): e264 (2006) (IF = 13.7 ; C = 24) PubMed

F. De Smet, P. Carmeliet & M. Autiero. Fishing and frogging for anti-angiogenic drugs. Nat Chem Biol 2: 228-9 (2006) (News and views) (IF = 13.7 ; C = 14) PubMed

M. Tjwa, P. Carmeliet & L. Moons. A novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis. Circulation 113: 1929-32 (2006) (Editorial) (IF = 11.1 ; C = 5) PubMed

S. Heymans, M. Pauschinger, A. De Palma, A. Kallwellis-Opara, S. Rutschow, M. Swinnen, D. Vanhoutte, F. Gao, R. Torpai, A. H. Baker, E. Padalko, J. Neyts, H. P. Schultheiss, F. Van de Werf, P. Carmeliet & Y. M. Pinto. Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis. Circulation 114: 565-73 (2006) (IF = 11.1 ; C = 109) PubMed

C.A. Remme, A.O. Verkerk, D. Nuyens, A.C. van Ginneken, S. van Brunschot, C.N. Belterman, R. Wilders, M.A. van Roon, H.L. Tan, A.A. Wilde, P. Carmeliet, J.M. de Bakker, M.W. Veldkamp & C.R. Bezzina. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 114: 2584-94 (2006) (IF = 11.1 ; C = 156) PubMed

S. Fredj, N. Lindegger, K. J. Sampson, P. Carmeliet & R. S. Kass. Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes. Circ Res 99: 1225-32 (2006) (IF = 9.4 C = 54) PubMed

H. R. Lijnen, V. Christiaens, I. Scroyen, G. Voros, M. Tjwa, P. Carmeliet & D. Collen. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55: 2698-704 (2006) (IF = 8.0 ; C  = 0) PubMed

B. Li, E. E. Sharpe, A. Maupin, A. A. Teleron, A. Pyle, P. Carmeliet & P. P. Young. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at site of tumor neovascularization. FASEB J 20: 1495-7 (IF = 7.0 ; C = 346) PubMed

R. Renckens, J. J. Roelofs, S. Florquin, A. F. de Vos, J. M. Pater, H. R. Lijnen, P. Carmeliet, C. van 't Veer & T. van der Poll. Endogenous Tissue-Type Plasminogen Activator Is Protective during Escherichia coli-Induced Abdominal Sepsis in Mice. J Immunol 177: 1189-96 (2006) (IF = 6.4 ; C = 49) PubMed

P. Rossignol, A. Luttun, J. L. Martin-Ventura, F. Lupu, P. Carmeliet, D. Collen, E. Angles-Cano & H. R. Lijnen. Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques. J Thromb Haemost 4: 664-70 (2006) (IF = 5.7 ; C. = 44) PubMed

D. Lambrechts, P. Lafuste, P. Carmeliet & E. M. Conway. Another angiogenic gene linked to amyotrophic lateral sclerosis. Trends Mol Med 12: 345-7 (2006) (IF = 5.5 ; C = 30) PubMed

S. A. Vinores, W. H. Xiao, S. Aslam, J. Shen, Y. Oshima, H. Nambu, H. Liu, P. Carmeliet & P. A. Campochiaro. Implication of the hypoxia response element of the vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development. J Cell Physiol 206: 749-58 (2006) (IF = 4.4 ; C. = 93) PubMed

A. Ny, M. Autiero & P. Carmeliet. Zebrafish and Xenopus tadpoles: Small animal models to study angiogenesis and lymphangiogenesis. Exp Cell Res 312: 684-93 (2005) (Review) (IF = 4.1 ; C = 62) PubMed

P. Vangheluwe, M. Tjwa, A. Van Den Bergh, W. E. Louch, M. Beullens, L. Dode, P. Carmeliet, E. Kranias, P. Herijgers, K. R. Sipido, L. Raeymaekers & F. Wuytack. A SERCA2 pump with an increased Ca(2+) affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. J Mol Cell Cardiol 41: 308-17 (2006) (IF = 3.9 ; C. = 52) PubMed

J. A. Alva, A. C. Zovein, A. Monvoisin, T. Murphy, A. Salazar, N. L. Harvey, P. Carmeliet & M. L. Iruela-Arispe. VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235: 759-67 (2006) (IF = 3.3 ; C. = 377) PubMed

D. M. Cochran, D. Fukumura, M. Ancukiewicz, P. Carmeliet & R. K. Jain. Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells. Ann Biomed Eng 34: 1247-58 (2006) (IF = 1.9 ; C = 47) PubMed

D. Lambrechts & P. Carmeliet. VEGF at the neurovascular interface: Therapeutic implications for motor neuron disease. Biochim Biophys Acta 1762: 1109-21 (2006) (Review) (IF = N/A ; C = 104) PubMed

P. Carmeliet. Angiogenesis in life, disease and medicine. Nature 438: 932-6 (2005) (Review) (IF = 29.2 ; C = 1,113) PubMed

P. Carmeliet & M. Tessier-Lavigne. Common mechanisms of nerve and blood vessel wiring. Nature 436: 193-200 (2005) (Review) (IF = 29.2 = C = 920) PubMed

A. Ny, M. Koch, M. Schneider, E. Neven, R.T. Tong, S. Maity, C. Fischer, S. Plaisance, D. Lambrechts, C. Heligon, S. Terclavers, M. Ciesiolka, R. Kalin, W.Y. Man, I. Senn, S. Wyns, F. Lupu, A. Brandli, K. Vleminckx, D. Collen, M. Dewerchin, E.M. Conway, L. Moons, R.K. Jain,  & P. Carmeliet. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med 11: 998-1004 (2005) (IF = 28.9 ; C = 200) PubMed

M. Schneider, E.M. Conway & P. Carmeliet. Lymph makes you fat. Nat Genet 37: 1023-4 (2005) (News and views) (IF = 25.8 ; C = 43) PubMed

E. Storkebaum, D. Lambrechts, M. Dewerchin, M. P. Moreno-Murciano, S. Appelmans, H. Oh, P. Van Damme, B. Rutten, W. Y. Man, M. De Mol, S. Wyns, D. Manka, K. Vermeulen, L. Van Den Bosch, N. Mertens, C. Schmitz, W. Robberecht, E. M. Conway, D. Collen, L. Moons & P. Carmeliet. Treatment of motoneuron degeneration by intracerebro-ventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 8: 85-92 (2005) (IF = 15.4 ; C = 484) (highlighted by (inter)-national press). PubMed

A. Angelillo-Scherrer, L. Burnier, N. Flores, P. Savi, M. DeMol, P. Schaeffer, J. M. Herbert, G. Lemke, S. P. Goff, G. K. Matsushima, H. S. Earp, C. Vesin, M. F. Hoylaerts, S. Plaisance, D. Collen, E. M. Conway, B. Wehrle-Haller & P. Carmeliet. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115: 237-46 (2005) (IF = 15.0 ; C = 258) PubMed

X. Li, M. Tjwa, L. Moons, P. Fons, A. Noel, A. Ny, J. M. Zhou, J. Lennartsson, H. Li, A. Luttun, A. Ponten, L. Devy, A. Bouche, H. Oh, A. Manderveld, S. Blacher, D. Communi, P. Savi, F. Bono, M. Dewerchin, J. M. Foidart, M. Autiero, J. M. Herbert, D. Collen, C. H. Heldin, U. Eriksson & P. Carmeliet. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest 115: 118-27 (2005) (IF = 15.0 ; C = 147) PubMed

T. Rossenbacker, K. Mubagwa, R. J. Jongbloed, J. Vereecke, K. Devriendt, M. Gewillig, E. Carmeliet, D. Collen, H. Heidbuchel & P. Carmeliet. Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome. Circulation 111: 961-8 (2005) (IF = 11.1 ; C = 40) PubMed

R. Khurana*, L. Moons, S. Shafi, A. Luttun, D. Collen, J. F. Martin, P. Carmeliet* & I. C. Zachary*. Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and Macrophage Accumulation. Circulation 111: 2828-36 (2005) (IF = 11.1 ; C = 151) PubMed

S. Heymans, B. Schroen, P. Vermeersch, H. Milting, F. Gao, A. Kassner, H. Gillijns, P. Herijgers, W. Flameng, P. Carmeliet, F. Van de Werf, Y. M. Pinto & S. Janssens. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Circulation 112: 1136-44 (2005) (IF = 11.1 ; C = 267) PubMed

S. M. Muller, G. Terszowski, C. Blum, C. Haller, V. Anquez, S. Kuschert, P. Carmeliet, H.G. Augustin & H.R. Rodewald. Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci USA 102: 10587-92 (2005) (IF = 10.2 ; C = 67) PubMed

I. Ott, C. Michaelis, M. Schuermann, B. Steppich, I. Seitz, M. Dewerchin, D. Zohlnhofer, R. Wessely, M. Rudelius, A. Schomig & P. Carmeliet. Vascular remodeling in mice lacking the cytoplasmic domain of tissue factor. Circ Res 97: 293-8 (2005) (IF = 9.4 ; C = 22) PubMed

A. Eichmann, F. Le Noble, M. Autiero & P. Carmeliet. Guidance of vascular and neural network formation. Curr Opin Neurobiol 15: 108-15 (2005) (Review) (IF = 8.5 ; C = 164) PubMed

I. Kryczek, A. Lange, P. Mottram, X. Alvarez, P. Cheng, M. Hogan, L. Moons, S. Wei, L. Zou, V. Machelon, D. Emilie, M. Terrassa, A. Lackner, T. J. Curiel, P. Carmeliet & W. Zou. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res 65: 465-72 (2005) (IF = 7.6 ; C = 408) PubMed

T. Acker, A. Diez-Juan, J. Aragones, M. Tjwa, K. Brusselmans, L. Moons, D. Fukumura, M.P. Moreno-Murciano, J.M. Herbert, A. Burger, J. Riedel, G. Elvert, I. Flamme, P.H. Maxwell, D. Collen, M. Dewerchin, R.K. Jain, K. Plate & P. Carmeliet. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 8: 131-41 (2005) (IF = 7.6 ; C = 193). PubMed

M. Schneider, M. Tjwa & P. Carmeliet. A surrogate marker to monitor angiogenesis at last. Cancer Cell 7: 3-4 (2005) (Preview) (IF = 7.6 ; C = 32) PubMed

K. D. Cowden Dahl, B. H. Fryer, F. A. Mack, V. Compernolle, E. Maltepe, D. M. Adelman, P. Carmeliet & M. C. Simon. Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 (2005) (IF = 7.1 ; C = 13) PubMed

E. Maquoi, G. Voros, P. Carmeliet, D. Collen & H. R. Lijnen. Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice. Arterioscler Thromb Vasc Biol 25: 1002-7 (2005) (IF = 7.0 ; C = 35 ) PubMed

S. Heymans, F. Lupu, S. Terclavers, B. Vanwetswinkel, J. M. Herbert, A. Baker, D. Collen, P. Carmeliet & L. Moons. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol 166: 15-25 (2005) (IF = 5.8 ; C = 165) PubMed

K. Brusselmans, F. Bono, D. Collen, J. M. Herbert, P. Carmeliet & M. Dewerchin. A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem 280: 3493-9 (2005) (IF = 5.8 ; C  = 103) PubMed

A. de Giorgio-Miller, S. Bottoms, G. Laurent, P. Carmeliet & S. Herrick. Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator. Am J Pathol 167: 721-32 (2005) (IF = 5.8 ; C = 36) PubMed

M. Autiero, F. De Smet, F. Claes & P. Carmeliet. Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65: 629-38 (2005) (Review) (IF = 5.3 ; C = 98) PubMed

R. Renckens, J. J. Roelofs, V. de Waard, S. Florquin, H. R. Lijnen, P. Carmeliet & T. van der Poll The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury. J Thromb Haemost 3: 1018-25 (2005) (IF = 5.2 ; C = 50) PubMed

S. Krag, C. C. Danielsen, P. Carmeliet, J. Nyengaard & L. Wogensen. Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease. Kidney Int 68: 2651-66 (2005) (IF = 4.9 ; C = 76) PubMed

M. R. Taylor, S. Kikkawa, A. Diez-Juan, V. Ramamurthy, K. Kawakami, P. Carmeliet & S. E. Brockerhoff. The Zebrafish pob Gene Encodes a Novel Protein Required for Survival of Red Cone Photoreceptor Cells. Genetics 170: 263-73 (2005) (IF = 4.3 ; C = 44) PubMed

T. Rossenbacker, E. Schollen, C. Kuiperi, T. J. de Ravel, K. Devriendt, G. Matthijs, D. Collen, H. Heidbuchel & P. Carmeliet. Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy. J Med Genet 42(5): e29 (2005) (IF = 4.3 ; C = 24) PubMed

D. Lambrechts, K. Devriendt, D.A. Driscoll, E. Goldmuntz, M. Gewillig, R. Vlietinck, D. Collen & P. Carmeliet. Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study. J Med Genet 42: 519-22 (2005) (Letter) (IF = 4.3 ; C = 63) PubMed

H. Roy, S. Bhardwaj, M. Babu, S. Jauhiainen, K. H. Herzig, A. R. Bellu, H. J. Haisma, P. Carmeliet, K. Alitalo & S. Yla-Herttuala. Adenovirus-Mediated Gene Transfer of Placental Growth Factor to Perivascular Tissue Induces Angiogenesis via Upregulation of the Expression of Endogenous Vascular Endothelial Growth Factor-A. Hum Gene Ther 16: 1422-8 (2005) (IF = 4.0 ; C = 61) PubMed

J. Krucken, M. A. Dkhil, J. V. Braun, R. M. Schroetel, M. El-Khadragy, P. Carmeliet, H. Mossmann & F. Wunderlich. Testosterone suppresses protective responses of the liver to blood-stage malaria. Infect Immun 73: 436-43 (2005) (IF = 3.9 ; C = 52) PubMed

C. Maillard, M. Jost, M. U. Romer, N. Brunner, X. Houard, A. Lejeune, C. Munaut, K. Bajou, L. Melen, K. Dano, P. Carmeliet, N. E. Fusenig, J. M. Foidart & A. Noel. Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner. Neoplasia 7: 57-66 (2005) (IF = 3.8 ; C = 43) PubMed

O. Hennebert, V. Laudenbach, A. Laquerriere, C. Verney, P. Carmeliet, S. Marret & P. Leroux. Ontogenic study of the influence of tissue plasminogen activator (t-PA) in neonatal excitotoxic brain insult and the subsequent microglia/macrophage activation. Neuroscience 130: 697-712 (2005) (IF = 3.4 ; C = 9) PubMed

E. Melis, L. Moons, J. Arnout, M.F. Hoylaerts, D. Collen, P. Carmeliet & M. Dewerchin. Thrombophilia in mice expressing tissue factor variant lacking its transmembrane and cytosolic domain. Biochem Biophys Res Commun. 333: 488-95 (2005) (IF = 3.0 ; C = 5) PubMed

L. Zanetta, M. Corada, M. Grazia Lampugnani, A. Zanetti, F. Breviario, L. Moons, P. Carmeliet, M.S. Pepper & E. Dejana. Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Thromb Haemost 93: 1041-6 (2005) (IF = 3.0 ; C = 28) PubMed

P. Carmeliet. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 Suppl 3: 4-10 (2005) (Review) (IF = 1.9 ; C = 1,387) PubMed

D. Lambrechts & P. Carmeliet. Sculpting heart valves with NFATc and VEGF. Cell 118: 532-4 (2004) (Review) (IF = 29.4 ; C = 28) PubMed

M. Azzouz, G. S. Ralph, E. Storkebaum, L. E. Walmsley, K. A. Mitrophanous, S. M. Kingsman, P. Carmeliet & N. D. Mazarakis. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429: 413-7 (2004) (IF = 29.3 ; C = 609) (highlighted by (inter)-national press) PubMed

D. Lambrechts & P. Carmeliet. Medicine: genetic spotlight on a blood defect. Nature 427: 592-4 (2004) (News and Views) (IF = 29.3 ; C = 5) PubMed

X. Lu, F. Le Noble, L. Yuan, Q. Jiang, B. De Lafarge, D. Sugiyama, C. Breant, F. Claes, F. De Smet, J. L. Thomas, M. Autiero, P. Carmeliet, M. Tessier-Lavigne & A. Eichmann. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432: 179-86 (2004) (IF = 29.3 ; C = 505) PubMed

M. Belting, M. I. Dorrell, S. Sandgren, E. Aguilar, J. Ahamed, A. Dorfleutner, P. Carmeliet, B. M. Mueller, M. Friedlander & W. Ruf. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 10: 502-9 (2004) (IF = 28.9 ; C = 324) PubMed

J. Auwerx, P. Avner, R. Baldock, A. Ballabio, R. Balling, M. Barbacid, A. Berns, A. Bradley, S. Brown, P. Carmeliet, P. Chambon, R. Cox, D. Davidson, K. Davies, D. Duboule, J. Forejt, F. Granucci, N. Hastie, M. H. de Angelis, I. Jackson, D. Kioussis, G. Kollias, M. Lathrop, U. Lendahl, M. Malumbres, H. von Melchner, W. Muller, J. Partanen, P. Ricciardi-Castagnoli, P. Rigby, B. Rosen, N. Rosenthal, B. Skarnes, A. F. Stewart, J. Thornton, G. Tocchini-Valentini, E. Wagner, W. Wahli & W. Wurst. The European dimension for the mouse genome mutagenesis program. Nat Genet 36: 925-7 (2004) (IF = 25.8 ; C = 179) PubMed

A. Luttun, M. Autiero, M. Tjwa & P. Carmeliet. Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets? Biochim Abiophys Acta 1654: 79-94 (2004) (Review) (IF = 16.1 ; C = 68) PubMed

C. Maes, I. Stockmans, K. Moermans, R. Van Looveren, N. Smets, P. Carmeliet, R. Bouillon & G. Carmeliet. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest 113: 188-99 (2004) (IF = 15.1 ; C = 235) PubMed

E. Storkebaum & P. Carmeliet. VEGF: a critical player in neurodegeneration. J Clin Invest 113: 14-8 (2004) (Invited Review) (IF = 15.1 ; C = 219) PubMed

A. Luttun, E. Lutgens, A. Manderveld, K. Maris, D. Collen, P. Carmeliet & L. Moons. Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation 109: 1408-14 (2004) (IF = 11.1 ; C = 298) PubMed

E.M. Conway & P. Carmeliet. A CLEVER molecule that regulates lymphocyte Trafficking. Blood 104: 13, 3840-3841 (2004) (Editorial) (IF = 10.3 ; C = 0)

K. De Gendt, J. V. Swinnen, P. T. Saunders, L. Schoonjans, M. Dewerchin, A. Devos, K. Tan, N. Atanassova, F. Claessens, C. Lecureuil, W. Heyns, P. Carmeliet, F. Guillou, R. M. Sharpe & G. Verhoeven. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A 101: 1327-32 (2004) (IF = 10.2 ; C = 667) PubMed

E. M. Conway & P. Carmeliet. The diversity of endothelial cells: a challenge for therapeutic angiogenesis. Genome Biol 5: 207 (2004) (Invited Review) (IF = 9.7 ; C = 56) PubMed

T. J. Curiel, P. Cheng, P. Mottram, X. Alvarez, L. Moons, M. Evdemon-Hogan, S. Wei, L. Zou, I. Kryczek, G. Hoyle, A. Lackner, P. Carmeliet & W. Zou. Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res 64: 5535-8 (2004) (IF = 7.6 ; C = 252) PubMed

A. Van Eynde, M. Nuytten, M. Dewerchin, L. Schoonjans, S. Keppens, M. Beullens, L. Moons,  P. Carmeliet, W. Stalmans & M. Bollen. The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol 24: 5863-74 (2004) (IF = 7.0 ; C = 29) PubMed

K. Bajou, C. Maillard, M. Jost, R. H. Lijnen, A. Gils, P. Declerck, P. Carmeliet, J. M. Foidart & A. Noel. Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene 23: 6986-90 (2004) (IF = 6.9 ; C = 142) PubMed

E. Storkebaum, D. Lambrechts & P. Carmeliet. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26: 943-54 (2004) (Review) (IF = 6.7 ; C = 489) PubMed

A. Lundkvist, A. Reichenbach, C. Betsholtz, P. Carmeliet, H. Wolburg & M. Pekny. Under stress, the absence of intermediate filaments from Muller cells in the retina has structural and functional consequences. J Cell Sci 117: 3481-8 (2004) (IF = 6.5 ; C = 122) PubMed

L. Sharma, E. Melis, M. J. Hickey, C. D. Clyne, J. Erlich, L. M. Khachigian, P. Davenport, E. Morand, P. Carmeliet & P. G. Tipping. The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Am J Pathol 165: 331-40 (2004) (IF = 5.8 ; C = 42) PubMed

Y. H. Yang, P. Hall, G. Milenkovski, L. Sharma, P. Hutchinson, E. Melis, P. Carmeliet, P. Tipping & E. Morand. Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice. Am J Pathol 164: 109-17 (2004) (IF = 5.8 ; C = 32) PubMed

D. Lambrechts, E. Storkebaum & P. Carmeliet. VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS? Trends Mol Med 10: 275-82 (2004) (Invited Review) (IF = 5.5 ; C = 48) PubMed

K. L. Edgtton, R. M. Gow, D. J. Kelly, P. Carmeliet & A. R. Kitching. Plasmin is not protective in experimental renal interstitial fibrosis. Kidney Int 66: 68-76 (2004) (IF = 4.9 ; C = 2) PubMed

O. Hennebert, S. Marret, P. Carmeliet, P. Gressens, A. Laquerriere & P. Leroux. Role of tissue-derived plasminogen activator (t-PA) in an excitotoxic mouse model of neonatal white matter lesions. J Neuropathol Exp Neurol 63: 53-63 (2004) (IF = 4.5 ; C = 13) PubMed

A. Luttun & P. Carmeliet. Angiogenesis and lymphangiogenesis: highlights of the past year. Curr Opin Hematol 11: 262-71 (2004) (Review) (IF =4.5 ; C = 23) PubMed

E. Padalko, D. Nuyens, A. De Palma, E. Verbeken, J. L. Aerts, E. De Clercq, P. Carmeliet & J. Neyts. The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis. Antimicrob Agents Chemother 48: 267-74 (2004) (IF = 4.3 ; C = 55) PubMed

P. Carmeliet. Manipulating angiogenesis in medicine. J Intern Med 255: 538-61 (2004) (Review) (IF = 4.0 ; C = 186) PubMed

L. Van Den Bosch, E. Storkebaum, V. Vleminckx, L. Moons, L. Vanopdenbosch, W. Scheveneels, P. Carmeliet, W. Robberecht. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiology of Disease 17: 21-8 (2004) (IF = 4.0 ; C = 111) PubMed

D. Lambrechts & P. Carmeliet. Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF. Curr Top Dev Biol 62: 189-224 (2004) (Review) (IF = 3.9 ; C = 31) PubMed

C. R. Molinas, M. Merces Binda, P. Carmeliet & P. R. Koninckx. Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice. Fertil Steril 82 Suppl 3: 1149-53 (2004) (IF = 3.1 ; C = 26) PubMed

E. Fordel, E. Geuens, S. Dewilde, P. Rottiers, P. Carmeliet, J. Grooten & L. Moens. Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR. Biochem Biophys Res Commun 319: 342-8 (2004) (IF = 3.0 ; C = 129) PubMed

A. Alam, J. P. Herault, P. Barron, B. Favier, P. Fons, N. Delesque-Touchard, I. Senegas, P. Laboudie, J. Bonnin, C. Cassan, P. Savi, B. Ruggeri, P. Carmeliet, F. Bono & J. M. Herbert. Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity. Biochem Biophys Res Commun 324: 909-15 (2004) (IF = 3.0 ; C = 61) PubMed

T. Rossenbacker, S.J. Carroll, H. Liu, C. Kuiperi, T.J. de Ravel, K. Devriendt, P. Carmeliet, R.S. Kass and H. Heidbuchel. Novel pore mutation in SCN5A manifests as a spectrum of phenotypes ranging from atrial flutter, conduction disease, and Brugada syndrome to sudden cardiac death. Heart Rhythm 1: 610-5 (2004) (IF = 2.6 ; C = 61) PubMed

E. M. Conway & P. Carmeliet. Cardiovascular biology: signalling silenced. Nature 425: 139-41 (2003) (Invited News and views) (IF = 29.3). PubMed

M. Autiero, J. Waltenberger, D. Communi, A. Kranz, L. Moons, D. Lambrechts, J. Kroll, S. Plaisance, M. De Mol, F. Bono, S. Kliche, G. Fellbrich, K. Ballmer-Hofer, D. Maglione, U. Mayr-Beyrle, M. Dewerchin, S. Dombrowski, D. Stanimirovic, P. Van Hummelen, C. Dehio, D. J. Hicklin, G. Persico, J. M. Herbert, M. Shibuya, D. Collen, E. M. Conway & P. Carmeliet. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med 9: 936-43 (2003) (IF = 28.9). PubMed

I. Stalmans, D. Lambrechts, F. De Smet, S. Jansen, J. Wang, S. Maity, P. Kneer, M. von der Ohe, A. Swillen, C. Maes, M. Gewillig, D. G. Molin, P. Hellings, T. Boetel, M. Haardt, V. Compernolle, M. Dewerchin, S. Plaisance, R. Vlietinck, B. Emanuel, A. C. Gittenberger-de Groot, P. Scambler, B. Morrow, D. A. Driscol, L. Moons, C. V. Esguerra, G. Carmeliet, A. Behn-Krappa, K. Devriendt, D. Collen, S. J. Conway & P. Carmeliet. VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Nat Med 9: 173-82 (2003) (IF = 28.9 ; C  = 224) PubMed

P. Carmeliet. Angiogenesis in health and disease. Nat Med 9: 653-60 (2003) (Invited Review) (IF = 28.9, C= 3,303) PubMed

D. Lambrechts, E. Storkebaum, M. Morimoto, J. Del-Favero, F. Desmet, S. L. Marklund, S. Wyns, V. Thijs, J. Andersson, I. van Marion, A. Al-Chalabi, S. Bornes, R. Musson, V. Hansen, L. Beckman, R. Adolfsson, H. S. Pall, H. Prats, S. Vermeire, P. Rutgeerts, S. Katayama, T. Awata, N. Leigh, L. Lang-Lazdunski, M. Dewerchin, C. Shaw, L. Moons, R. Vlietinck, K. E. Morrison, W. Robberecht, C. Van Broeckhoven, D. Collen, P. M. Andersen & P. Carmeliet. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 34: 383-94 (2003) (with accompanying News and views; highlighted by (inter)-national press) (IF = 25.8 ; C = 709) PubMed

P. Carmeliet. Blood vessels and nerves: common signals, pathways and diseases. Nat Rev Genet 4: 710-20 (2003) (Invited Review) (IF = 19.2 ; C = 408) PubMed

A. Luttun & P. Carmeliet. Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? J Clin Invest 111: 600-2 (2003) (News and Views) (IF = 15.1 ; C = 107) PubMed

K. Brusselmans, V. Compernolle, M. Tjwa, M. S. Wiesener, P. H. Maxwell, D. Collen & P. Carmeliet. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111: 1519-27 (2003) (IF = 15.1 ; C = 243) PubMed

M. Levi, J. Dorffler-Melly, P. Reitsma, H. Buller, S. Florquin, T. van der Poll & P. Carmeliet. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. Blood 101: 4823-7 (2003) (IF = 10.3 ; C = 127) PubMed

H. Oura, J. Bertoncini, P. Velasco, L. F. Brown, P. Carmeliet & M. Detmar. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood 101: 560-7 (2003) (IF = 10.3 ; C = 137) PubMed

A. W. Rijneveld, S. Florquin, P. Bresser, M. Levi, V. De Waard, R. Lijnen, J. S. Van Der Zee, P. Speelman, P. Carmeliet & T. Van Der Poll. Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia. Blood 102: 934-9 (2003) (IF = 10.3 ; C = 73) PubMed

G. G. Deng, B. Martin-McNulty, D. A. Sukovich, A. Freay, M. Halks-Miller, T. Thinnes, D. J. Loskutoff, P. Carmeliet, W. P. Dole & Y. X. Wang. Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res 92: 510-7 (2003) (IF = 9.4 ; C  = 139) PubMed

M. Dewerchin, J. P. Herault, G. Wallays, M. Petitou, P. Schaeffer, L. Millet, J. I. Weitz, L. Moons, D. Collen, P. Carmeliet & J. M. Herbert. Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin. Circ Res 93: 1120-6 (2003) (IF = 9.4 ; C = 23) PubMed

F. Pipp, M. Heil, K. Issbrucker, T. Ziegelhoeffer, S. Martin, J. van den Heuvel, H. Weich, B. Fernandez, G. Golomb, P. Carmeliet, W. Schaper & M. Clauss. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ Res 92: 378-85 (2003) (IF = 9.4 ; C = 251) PubMed

P. Brites, A. M. Motley, P. Gressens, P. A. Mooyer, I. Ploegaert, V. Everts, P. Evrard, P. Carmeliet, M. Dewerchin, L. Schoonjans, M. Duran, H. R. Waterham, R. J. Wanders & M. Baes. Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum Mol Genet 12: 2255-67 (2003) (IF = 7.8 ; C = 93) PubMed

C. Roca, L. Primo, D. Valdembri, A. Cividalli, P. Declerck, P. Carmeliet, P. Gabriele & F. Bussolino. Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism. Cancer Res 63: 1500-7 (2003) (IF = 7.6 ; C = 71) PubMed

A. Janssen, P. Gressens, M. Grabenbauer, E. Baumgart, A. Schad, I. Vanhorebeek, A. Brouwers, P. E. Declercq, D. Fahimi, P. Evrard, L. Schoonjans, D. Collen, P. Carmeliet, G. Mannaerts, P. Van Veldhoven & M. Baes. Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues. J Neurosci 23: 9732-41 (2003) (IF = 7.5 ; C = 44) PubMed

A. R. Kitching, Y. Z. Kong, X. R. Huang, P. Davenport, K. L. Edgtton, P. Carmeliet, S. R. Holdsworth & P. G. Tipping. Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol 14: 1487-95 (2003) (IF = 7.2 ; C = 71) PubMed

G. Zhang, H. Kim, X. Cai, J. M. Lopez-Guisa, C. E. Alpers, Y. Liu, P. Carmeliet & A. A. Eddy. Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. J Am Soc Nephrol 14: 1254-71 (2003) (IF = 7.2 ; C = 96) PubMed

G. Zhang, H. Kim, X. Cai, J. M. Lopez-Guisa, P. Carmeliet & A. A. Eddy. Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol 14: 1234-53 (2003) (IF = 7.2 ; C = 96) PubMed

A. Hertig, J. Berrou, Y. Allory, L. Breton, F. Commo, M. A. Costa De Beauregard, P. Carmeliet & E. Rondeau. Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through overactivation of transforming growth factor beta. Faseb J 17: 1904-6 (2003) (IF = 7.1 ; C = 52) PubMed

E. Deindl, T. Ziegelhoffer, S. M. Kanse, B. Fernandez, E. Neubauer, P. Carmeliet, K. T. Preissner & W. Schaper. Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis. FASEB J 17: 1174-6 (2003) (IF = 7.1 ; C = 42) PubMed

S. J. Van Cromphaut, K. Rummens, I. Stockmans, E. Van Herck, F. A. Dijcks, A. G. Ederveen, P. Carmeliet, J. Verhaeghe, R. Bouillon & G. Carmeliet. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J Bone Miner Res 18: 1725-36 (2003) (IF = 6.5 ; C = 165) PubMed

A. Reijerkerk, L. O. Mosnier, O. Kranenburg, B. N. Bouma, P. Carmeliet, T. Drixler, J. C. Meijers, E. E. Voest & M. F. Gebbink. Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system. Mol Cancer Res 1: 561-8 (2003) (IF = 5.4 ; C = 38) PubMed

A. Luttun & P. Carmeliet. De novo vasculogenesis in the heart. Cardiovasc Res 58: 378-89 (2003) (Invited Review) (IF = 5.3 ; C = 76) PubMed

V. Compernolle, K. Brusselmans, D. Franco, A. Moorman, M. Dewerchin, D. Collen & P. Carmeliet. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res 60: 569-79 (2003) (IF =5.3 ; C = 157) PubMed

L. Fabritz, P. Kirchhof, M. R. Franz, D. Nuyens, T. Rossenbacker, A. Ottenhof, W. Haverkamp, G. Breithardt, E. Carmeliet & P. Carmeliet. Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. Cardiovasc Res 57: 1085-93 (2003) (IF = 5.3 ; C = 73) PubMed

C. J. Gruss, K. Satyamoorthy, C. Berking, J. Lininger, M. Nesbit, H. Schaider, Z. J. Liu, M. Oka, M. Y. Hsu, T. Shirakawa, G. Li, T. Bogenrieder, P. Carmeliet, W. S. El-Deiry, S. L. Eck, J. S. Rao, A. H. Baker, J. T. Bennet, T. M. Crombleholme, O. Velazquez, J. Karmacharya, D. J. Margolis, J. M. Wilson, M. Detmar, M. Skobe, P. D. Robbins, C. Buck & M. Herlyn. Stroma formation and angiogenesis by overexpression of growth factors, cytokines and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol 120: 683-92 (2003) (IF = 4.4 ; C = 41) PubMed

D. Scholz, H. Elsaesser, A. Sauer, C. Friedrich, A. Luttun, P. Carmeliet & W. Schaper. Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) -/- mice. J Mol Cell Cardiol 35: 177-84 (2003) (IF = 3.9 ; C = 58) PubMed

T. A. Drixler, J. M. Vogten, M. F. Gebbink, P. Carmeliet, E. E. Voest & I. H. Borel Rinkes. Plasminogen mediates liver regeneration and angiogenesis after experimental partial hepatectomy. Br J Surg 90: 1384-90 (2003) (IF = 3.7 ; C = 36) PubMed

V. Lambert, C. Munaut, P. Carmeliet, R. D. Gerard, P. J. Declerck, A. Gils, C. Claes, J. M. Foidart, A. Noel & J. M. Rakic. Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials. Invest Ophthalmol Vis Sci 44: 2791-7 (2003) (IF = 3.6. ; C = 44) PubMed

J. M. Rakic, V. Lambert, L. Devy, A. Luttun, P. Carmeliet, C. Claes, L. Nguyen, J. M. Foidart, A. Noel & C. Munaut. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci 44: 3186-93 (2003) (IF = 3.6 ; C = 274) PubMed

J. M. Rakic, V. Lambert, C. Munaut, K. Bajou, K. Peyrollier, M. L. Alvarez-Gonzalez, P. Carmeliet, J. M. Foidart & A. Noel. Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 44: 1732-9 (2003) (IF = 3.6 ; C = 51) PubMed

M. Autiero, A. Luttun, M. Tjwa & P. Carmeliet. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost 1: 1356-70 (2003) (invited review) (IF = 3.1 ; C = 336) PubMed

C. R. Molinas, R. Campo, M. Dewerchin, U. Eriksson, P. Carmeliet & P. R. Koninckx. Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 Suppl 2: 803-11 (2003) (IF = 3.1 ; C = 49) PubMed

C. R. Molinas, R. Campo, O. A. Elkelani, M. M. Binda, P. Carmeliet & P. R. Koninckx. Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 Suppl 2: 795-802 (2003) (IF = 3.1 ; C = 56) PubMed

C. R. Molinas, O. Elkelani, R. Campo, A. Luttun, P. Carmeliet & P. R. Koninckx. Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80: 184-92 (2003) (IF = 3.1 ; C = 54) PubMed

T. Jin, A. Tarkowski, P. Carmeliet & M. Bokarewa. Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis. Arthritis Res Ther 5: R9-R17 (2003) (IF = 2.9 ; C = 48) PubMed

M. Tjwa, A. Luttun, M. Autiero & P. Carmeliet. VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res 314: 5-14 (2003) (Invited Review). (IF = 2.4 ; C = 156) PubMed

D. Collen, P. Carmeliet, C. Brunaud & L. Schoonjans. Cardiovascular stem cell research in interactions between the university and industry. Verh K Acad Geneeskd Belg 65: 281-2 (2003) (Review) (IF = N/A ; C = 0) PubMed

E. Melis, S. Heymans & P. Carmeliet Preventie van trombose: de nieuwkomer anti-Gas6-therapie versus gevestigde waarden. Bloedvaten, Hart & Longen 8: 40-44 (2003) (Review) (IF = N/A ; C = 0)

F. Blasi & P. Carmeliet. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3: 932-43 (2002) (Review) (IF = 29.8 ; C = 1,052) PubMed

A. Luttun, M. Tjwa, L. Moons, Y. Wu, A. Angelillo-Scherrer, F. Liao, J. A. Nagy, A. Hooper, J. Priller, B. De Klerck, V. Compernolle, E. Daci, P. Bohlen, M. Dewerchin, J. M. Herbert, R. Fava, P. Matthys, G. Carmeliet, D. Collen, H. F. Dvorak, D. J. Hicklin & P. Carmeliet. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8: 831-40 (2002) (cover with News and views; editorials in Nature Cancer Reviews, Nature) (IF = 28.9 ; C = 854) PubMed

V. Compernolle, K. Brusselmans, T. Acker, P. Hoet, M. Tjwa, H. Beck, S. Plaisance, Y. Dor, E. Keshet, F. Lupu, B. Nemery, M. Dewerchin, P. Van Veldhoven, K. Plate, L. Moons, D. Collen & P. Carmeliet. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-10 (2002) (cover with News and views; and editorials in Science, Nature, Lancet) (IF = 28.9 ; C = 583) PubMed

P. Carmeliet. Integrin indecision. Nat Med 8: 14-6 (2002) (Invited News and views) (IF = 28.9 ; C = 47) PubMed

K. Alitalo & P. Carmeliet. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1: 219-27 (2002) (Review) (IF = 18.7 ; C = 549) PubMed

I. Stalmans, Y. S. Ng, R. Rohan, M. Fruttiger, A. Bouche, A. Yuce, H. Fujisawa, B. Hermans, M. Shani, S. Jansen, D. Hicklin, D. J. Anderson, T. Gardiner, H. P. Hammes, L. Moons, M. Dewerchin, D. Collen, P. Carmeliet & P. A. D'Amore. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest 109: 327-36 (2002) (IF = 15.1 ; C = 387) PubMed

M. Suelves, R. Lopez-Alemany, F. Lluis, G. Aniorte, E. Serrano, M. Parra, P. Carmeliet & P. Munoz-Canoves. Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. Blood 99: 2835-44 (2002) (IF = 10.3 ; C = 90) PubMed

R. Pawlinski, A. Fernandes, B. Kehrle, B. Pedersen, G. Parry, J. Erlich, R. Pyo, D. Gutstein, J. Zhang, F. Castellino, E. Melis, P. Carmeliet, G. Baretton, T. Luther, M. Taubman, E. Rosen & N. Mackman. Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. Proc Natl Acad Sci U S A 99: 15333-8 (2002) (IF = 10.2 ; C = 89) PubMed

H. Kojima, H. Gu, S. Nomura, C. C. Caldwell, T. Kobata, P. Carmeliet, G. L. Semenza & M. V. Sitkovsky. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc Natl Acad Sci U S A 99: 2170-4 (2002) (IF = 10.2 ; C = 181) PubMed

Y. Dor, V. Djonov, R. Abramovitch, A. Itin, G. I. Fishman, P. Carmeliet, G. Goelman & E. Keshet. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J 21: 1939-47 (2002) (IF = 10.1 ; C = 313) PubMed

V. Mattot, L. Moons, F. Lupu, D. Chernavvsky, R. A. Gomez, D. Collen & P. Carmeliet. Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J Am Soc Nephrol 13: 1548-60 (2002) (IF = 7.2 ; C = 79) PubMed

V. de Waard, E. K. Arkenbout, P. Carmeliet, V. Lindner & H. Pannekoek. Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation model. Arterioscler Thromb Vasc Biol 22: 1978-83 (2002) (IF = 7.1 ; C = 59) PubMed

A. Luttun, F. Lupu, E. Storkebaum, M. F. Hoylaerts, L. Moons, J. Crawley, F. Bono, A. R. Poole, P. Tipping, J. M. Herbert, D. Collen & P. Carmeliet. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 22: 499-505 (2002) (IF = 7.1 ; C = 107) PubMed

L. Devy, S. Blacher, C. Grignet-Debrus, K. Bajou, V. Masson, R. D. Gerard, A. Gils, G. Carmeliet, P. Carmeliet, P. J. Declerck, A. Noel & J.M. Foidart. The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent. FASEB J 16: 147-54 (2002) (IF = 7.1 ; C = 238) PubMed

A. W. Rijneveld, M. Levi, S. Florquin, P. Speelman, P. Carmeliet & T. van Der Poll. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J Immunol 168: 3507-11 (2002) (IF = 6.3 ; C. = 164) PubMed

H. Beck, T. Acker, A. W. Puschel, H. Fujisawa, P. Carmeliet & K. H. Plate. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. J Neuropathol Exp Neurol 6: 339-50 (2002) (IF = 4.7 ; C = 90) PubMed

A. Luttun, G. Carmeliet & P. Carmeliet. Vascular progenitors: from biology to treatment. Trends Cardiovasc Med 12: 88-96 (2002) (Review) (IF = 4.7 ; C. = 150) PubMed

F. Docagne, O. Nicole, C. Gabriel, M. Fernandez-Monreal, S. Lesne, C. Ali, L. Plawinski, P. Carmeliet, E. T. MacKenzie, A. Buisson & D. Vivien. Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis. Mol Cell Neurosci 21: 634-44 (2002) (IF = 4.6 ; C. = 70) PubMed

P. Carmeliet & E. Storkebaum. Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol 13: 39-53 (2002) (Review) (IF = 4.5 ; C. = 202) PubMed

C. Maes, P. Carmeliet, K. Moermans, I. Stockmans, N. Smets, D. Collen, R. Bouillon & G. Carmeliet. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev 111: 61-73 (2002) (IF = 3.8 ; C = 0) PubMed

A. Luttun, K. Brusselmans, H. Fukao, M. Tjwa, S. Ueshima, J. M. Herbert, O. Matsuo, D. Collen, P. Carmeliet & L. Moons. Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun 295: 428-34 (2002) (IF = 3.0 ; C. = 69) PubMed

M. Baes, M. Dewerchin, A. Janssen, D. Collen & P. Carmeliet. Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes. Genesis 32: 177-8 (2002) (IF = 2.6 ; C = 27) PubMed

A. Luttun, M. Tjwa & P. Carmeliet. Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann N Y Acad Sci 979: 80-93 (2002) (Review) (IF = 1.9 C = 164) PubMed

A. Angelillo-Scherrer, D. Collen & P. Carmeliet. Gas6, une nouvelle protéine d'hémostase. Hématologie 8: 173-180 (2002) (IF = N/A ; C = 0)

V. V. Masson, L. Devy, C. Grignet-Debrus, S. Bernt, K. Bajou, S. Blacher, G. Roland, Y. Chang, T. Fong, P. Carmeliet, J. M. Foidart & A. Noel. Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis. Biol Proced Online 4: 24-31 (2002) (IF = N/A ; C = 0) PubMed

P. Carmeliet. Biomedicine. Clotting factors build blood vessels. Science 293: 1602-4 (2001) (Invited Perspective) (IF = 30.9 ; C = 79) PubMed

P. Carmeliet. Cardiovascular biology. Creating unique blood vessels. Nature 412: 868-9 (2001) (Invited News and views) (IF = 29.3 ; C = 28) PubMed

P. Carmeliet, L. Moons, A. Luttun, V. Vincenti, V. Compernolle, M. De Mol, Y. Wu, F. Bono, L. Devy, H. Beck, D. Scholz, T. Acker, T. DiPalma, M. Dewerchin, A. Noel, I. Stalmans, A. Barra, S. Blacher, T. Vandendriessche, A. Ponten, U. Eriksson, K. H. Plate, J. M. Foidart, W. Schaper, D. S. Charnock-Jones, D. J. Hicklin, J. M. Herbert, D. Collen & M. G. Persico. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-83 (2001) (IF = 28.9 ; C = 1,296) PubMed

A. Angelillo-Scherrer, P. de Frutos, C. Aparicio, E. Melis, P. Savi, F. Lupu, J. Arnout, M. Dewerchin, M. Hoylaerts, J. Herbert, D. Collen, B. Dahlback & P. Carmeliet. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med 7: 215-21 (2001) (IF = 28.9 ; C = 349) (highlighted by (inter)-national press). PubMed

E. B. Brown, R. B. Campbell, Y. Tsuzuki, L. Xu, P. Carmeliet, D. Fukumura & R. K. Jain. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med 7: 864-8 (2001) (IF = 28.9 ; C = 477) PubMed

O. Nicole, F. Docagne, C. Ali, I. Margaill, P. Carmeliet, E. T. MacKenzie, D. Vivien & A. Buisson. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 7: 59-64 (2001) (IF = 28.9 ; C =593) PubMed

D. Nuyens, M. Stengl, S. Dugarmaa, T. Rossenbacker, V. Compernolle, Y. Rudy, J. F. Smits, W. Flameng, C. E. Clancy, L. Moons, M. A. Vos, M. Dewerchin, K. Benndorf, D. Collen, E. Carmeliet & P. Carmeliet. Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med 7: 1021-7 (2001) (IF = 28.9 ; C = 203) PubMed

P. Carmeliet. Jeffrey Michael Isner 1947-2001. Nat Med 7: 1269 (2001) (Invited Obituary) (IF = 28.9 ; C = 0)

B. Oosthuyse, L. Moons, E. Storkebaum, H. Beck, D. Nuyens, K. Brusselmans, J. Van Dorpe, P. Hellings, M. Gorselink, S. Heymans, G. Theilmeier, M. Dewerchin, V. Laudenbach, P. Vermylen, H. Raat, T. Acker, V. Vleminckx, L. Van Den Bosch, N. Cashman, H. Fujisawa, M. R. Drost, R. Sciot, F. Bruyninckx, D. J. Hicklin, C. Ince, P. Gressens, F. Lupu, K. H. Plate, W. Robberecht, J. M. Herbert, D. Collen & P. Carmeliet. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 28: 131-8 (2001) (with accompanying News and views in Nature Genetics and editorials in Science, Nature Medicine, Nature, Lancet; highlighted by (inter)-national press). (IF = 25.8 ; C =815) PubMed

P. Carmeliet & E. M. Conway. Growing better blood vessels. Nat Biotechnol 19: 1019-20 (2001) (Invited News and views) (IF = 22.7 ; C = 66) PubMed

M. Levi, L. Moons, A. Bouche, S. D. Shapiro, D. Collen & P. Carmeliet. Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice. Circulation 103: 2014-20 (2001) (IF = 11.6 ; C = 49) PubMed

K. Bajou, V. Masson, R. D. Gerard, P. M. Schmitt, V. Albert, M. Praus, L. R. Lund, T. L. Frandsen, N. Brunner, K. Dano, N. E. Fusenig, U. Weidle, G. Carmeliet, D. Loskutoff, D. Collen, P. Carmeliet, J. M. Foidart & A. Noel. The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J Cell Biol 152: 777-84 (2001) (IF = 10.9 C = 288) PubMed

F. Lluis, J. Roma, M. Suelves, M. Parra, G. Aniorte, E. Gallardo, I. Illa, L. Rodriguez, S. M. Hughes, P. Carmeliet, M. Roig & P. Munoz-Canoves. Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo. Blood 97: 1703-11 (2001) (IF = 10.3 ; C = 101) PubMed

M. Ver Heyen, S. Heymans, G. Antoons, T. Reed, M. Periasamy, B. Awede, J. Lebacq, P. Vangheluwe, M. Dewerchin, D. Collen, K. Sipido, P. Carmeliet & F. Wuytack. Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circ Res 89: 838-46 (2001) (IF = 9.4 ; C = 82) PubMed

Y. Dor, T. D. Camenisch, A. Itin, G. I. Fishman, J. A. McDonald, P. Carmeliet & E. Keshet. A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128: 1531-8 (2001) (IF = 7.6 ; C = 191) PubMed

A. Kadambi, C. Mouta Carreira, C. O. Yun, T. P. Padera, D. E. Dolmans, P. Carmeliet, D. Fukumura & R. K. Jain. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res 61: 2404-8 (2001) (IF = 7.6 ; C = 82) PubMed

T. L. Frandsen, C. Holst-Hansen, B. S. Nielsen, I. J. Christensen, J. R. Nyengaard, P. Carmeliet & N. Brunner. Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. Cancer Res 61: 532-7 (2001) (IF = 7.6 ; C = 62) PubMed

V. Lambert, C. Munaut, A. Noel, F. Frankenne, K. Bajou, R. Gerard, P. Carmeliet, M. P. Defresne, J. M. Foidart & J. M. Rakic. Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. FASEB J 15: 1021-7 (2001) (IF = 7.1 ; C = 80) PubMed

K. Brusselmans, F. Bono, P. Maxwell, Y. Dor, M. Dewerchin, D. Collen, J. M. Herbert & P. Carmeliet. Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia. J Biol Chem 276: 39192-6 (2001) (IF = 5.9 ; C = 90) PubMed

P. Carmeliet & A. Luttun. The emerging role of the bone marrow-derived stem cells in (therapeutic) angiogenesis. Thromb Haemost 86: 289-97 (2001) (Review) (IF = 3.1 ; C = 96) PubMed

P. Carmeliet What are the candidate pathologies for therapeutic angiogenesis. Dialogues in Cardiovascular Medicine 6: 173-181 (2001) (Invited Review) (IF = N/A ; C = 0)

E. M. Conway, D. Collen & P. Carmeliet. Molecular mechanisms of blood vessel growth. Cardiovasc Res 49: 507-21 (2001) (Invited Review) (IF = 5.3 ; C = 750) PubMed

J. M. Herbert, D. de Prost, V. Ollivier, E. Melis & P. Carmeliet. Tissue factor is not involved in the mitogenic activity of factor VIIa. Biochem Biophys Res Commun 281: 1074-7 (2001) (IF = 3.0 ; C = 6) PubMed

C. Holst-Hansen, J. A. Low, R. W. Stephens, M. D. Johnson, P. Carmeliet, T. L. Frandsen, N. Brunner & R. B. Dickson. Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat. Breast Cancer Res Treat 68: 225-37 (2001) (IF = 4.6 ; C = 10) PubMed

R. K. Jain & P. Carmeliet. Vessels of death or life. Sci Am 285, 38-45 (2001) (Review) (IF = 1.9 ;  C = 72)

A. Luttun & P. Carmeliet. Genetic studies on the role of proteinases and growth factors in atherosclerosis and aneurysm formation. Ann N Y Acad Sci 947: 124-32; discussion 132-3 (2001) (IF = 1.9 ; C = 10) PubMed

E. Melis, L. Moons, M. De Mol, J. M. Herbert, N. Mackman, D. Collen, P. Carmeliet & M. Dewerchin. Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem Biophys Res Commun 286: 580-6 (2001) (IF = 3.0 ; C  = 45) PubMed

I. Rajantie, N. Ekman, K. Iljin, E. Arighi, Y. Gunji, J. Kaukonen, A. Palotie, M. Dewerchin, P. Carmeliet & K. Alitalo. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol 21: 4647-55 (2001) (IF = 7.1 ; C = 67) PubMed

S. J. Van Cromphaut, M. Dewerchin, J. G. Hoenderop, I. Stockmans, E. Van Herck, S. Kato, R. J. Bindels, D. Collen, P. Carmeliet, R. Bouillon & G. Carmeliet. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A 98: 13324-9 (2001) (IF = 10.2 ; C = 436) PubMed

Y. H. Yang, P. Carmeliet & J. A. Hamilton. Tissue-type plasminogen activator deficiency exacerbates arthritis. J Immunol 167: 1047-52 (2001) (IF = 6.4 ; C = 0) PubMed

R. Yiou, V. Delmas, P. Carmeliet, R. K. Gherardi, G. Barlovatz-Meimon, D. K. Chopin, C. C. Abbou & J. P. Lefaucheur. The pathophysiology of pelvic floor disorders: evidence from a histomorphologic study of the perineum and a mouse model of rectal prolapse. J Anat 199: 599-607 (2001) (IF = 2.1 ; C = 31) PubMed

J. L. Yu, J. W. Rak, P. Carmeliet, A. Nagy, R. S. Kerbel & B. L. Coomber. Heterogeneous vascular dependence of tumor cell populations. Am J Pathol 158: 1325-34 (2001) (IF = 5.8 ; C = 111) PubMed

P. Carmeliet & R. K. Jain. Angiogenesis in cancer and other diseases. Nature 407: 249-57 (2000) (Invited Review) (IF = 29.3; C = 8,273) (highlighted by (inter)-national press). PubMed

P. Carmeliet. Developmental biology. One cell, two fates. Nature 408: 43, 45 (2000) (Invited News and views) (IF = 29.3 ; C = 66) PubMed

P. Carmeliet. VEGF gene therapy: stimulating angiogenesis or angioma-genesis? Nat Med 6: 1102-3 (2000) (Invited News and views) (IF = 28.9). PubMed

J. Li, M. Post, R. Volk, Y. Gao, M. Li, C. Metais, K. Sato, J. Tsai, W. Aird, R. D. Rosenberg, T. G. Hampton, F. Sellke, P. Carmeliet & M. Simons. PR39, a peptide regulator of angiogenesis. Nat Med 6: 49-55 (2000) (IF = 28.9 ; C = 388) PubMed

P. Carmeliet. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389-95 (2000) (Invited Review) (IF = 28.3 ; C = 3,800) PubMed

P. Uhrin, M. Dewerchin, M. Hilpert, P. Chrenek, C. Schofer, M. Zechmeister-Machhart, G. Kronke, A. Vales, P. Carmeliet, B. R. Binder & M. Geiger. Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106: 1531-9 (2000) (IF = 15.1 ; C = 130) PubMed

P. Carmeliet. Proteinases in cardiovascular aneurysms and rupture: targets for therapy? J Clin Invest 105: 1519-20 (2000) (Invited Commentary) (IF = 15.1 ; C = 43) PubMed

V. L. Bautch, S. D. Redick, A. Scalia, M. Harmaty, P. Carmeliet & R. Rapoport. Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A. Blood 95: 1979-87 (2000) (IF = 10.3 ; C = 52) PubMed

P. Carmeliet. Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: a goal for therapeutic angiogenesis? Circ Res 87: 176-8 (2000) (Invited editorial). (IF = 9.4 ; C = 59) PubMed

Y. Tsuzuki, D. Fukumura, B. Oosthuyse, C. Koike, P. Carmeliet & R. K. Jain. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res 60: 6248-52 (2000) (IF = 7.6 ; C = 259) PubMed

P. Jacquemin, S. M. Durviaux, J. Jensen, C. Godfraind, G. Gradwohl, F. Guillemot, O. D. Madsen, P. Carmeliet, M. Dewerchin, D. Collen, G. G. Rousseau & F. P. Lemaigre. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 20: 4445-54 (2000) (IF = 7.1 ; C = 308) PubMed

P. Carmeliet & D. Collen. Transgenic mouse models in angiogenesis and cardiovascular disease. J Pathol 190: 387-405 (2000) (Invited Review) (IF = 6.2 ; C = 127) PubMed

M. Baes, S. Huyghe, P. Carmeliet, P. E. Declercq, D. Collen, G. P. Mannaerts & P. P. Van Veldhoven. Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids. J Biol Chem 275: 16329-36 (2000) (IF = 5.9 ; C = 176) PubMed

E. Creemers, J. Cleutjens, J. Smits, S. Heymans, L. Moons, D. Collen, M. Daemen & P. Carmeliet. Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am J Pathol 156: 1865-73 (2000) (IF = 5.8 ; C = 139) PubMed

M. Dewerchin, Z. Liang, L. Moons, P. Carmeliet, F. J. Castellino, D. Collen & E. D. Rosen. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost 83: 185-90 (2000) (IF = 3.1 ; C = 134) PubMed

K. Kataoka, T. Asai, M. Taneda, S. Ueshima, O. Matsuo, R. Kuroda, A. Kawabata & P. Carmeliet. Roles of urokinase type plasminogen activator in a brain stab wound. Brain Res 887: 187-90 (2000) (IF = 2.3 ; C = 20) PubMed

P. Carmeliet & D. Collen. Molecular basis of angiogenesis. Role of VEGF and VE-cadherin. Ann N Y Acad Sci 902: 249-62; discussion 262-4 (2000) (Invited Review) (IF = 1.9 ; C = 255) PubMed

P. Carmeliet. Gene targeting and gene transfer to unravel the molecular basis of the formation and disorders of blood vessels. Verh K Acad Geneeskd Belg 62: 31-68 (2000) (Review) (IF = N/A ; C = 6) PubMed

A. Luttun, M. Dewerchin, D. Collen & P. Carmeliet. The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies. Curr Atheroscler Rep 2: 407-16 (2000) (Invited Review) (IF = N/A ; C = 55) PubMed

P. Carmeliet, M. G. Lampugnani, L. Moons, F. Breviario, V. Compernolle, F. Bono, G. Balconi, R. Spagnuolo, B. Oostuyse, M. Dewerchin, A. Zanetti, A. Angellilo, V. Mattot, D. Nuyens, E. Lutgens, F. Clotman, M. C. de Ruiter, A. Gittenberger-de Groot, R. Poelmann, F. Lupu, J. M. Herbert, D. Collen & E. Dejana. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98: 147-57 (1999) (IF = 29.4 ; C = 1,180) PubMed

P. Carmeliet. Developmental biology. Controlling the cellular brakes. Nature 401: 657-8 (1999) (News and views) (IF = 29.3 ; C = 48) PubMed

P. Carmeliet, Y. S. Ng, D. Nuyens, G. Theilmeier, K. Brusselmans, I. Cornelissen, E. Ehler, V. V. Kakkar, I. Stalmans, V. Mattot, J. C. Perriard, M. Dewerchin, W. Flameng, A. Nagy, F. Lupu, L. Moons, D. Collen, P. A. D'Amore & D. T. Shima. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med 5: 495-502 (1999) (IF = 28.9 ; C = 580) PubMed